International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Authors
Keywords
-
Journal
PHARMACOLOGICAL REVIEWS
Volume 73, Issue 1, Pages 521-569
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2020-12-24
DOI
10.1124/pr.119.019133
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson’s disease
- (2020) Irene Sebastianutto et al. JOURNAL OF CLINICAL INVESTIGATION
- Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes
- (2020) Shane D. Hellyer et al. ACS Chemical Neuroscience
- Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism
- (2020) Kathy Sengmany et al. BIOCHEMICAL PHARMACOLOGY
- Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site
- (2020) Shane D. Hellyer et al. BIOCHEMICAL PHARMACOLOGY
- Detailed in vitro pharmacological characterization of clinically tested negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
- (2020) Angela Arsova et al. MOLECULAR PHARMACOLOGY
- Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors
- (2020) Joon Lee et al. Cell Reports
- Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
- (2019) Vanessa Pereira et al. Frontiers in Molecular Neuroscience
- Role of Metabotropic Glutamate Receptors in Neurological Disorders
- (2019) Rosalia Crupi et al. Frontiers in Molecular Neuroscience
- Structural insights into the activation of metabotropic glutamate receptors
- (2019) Antoine Koehl et al. NATURE
- Serotonin and Glutamate Interactions in Preclinical Schizophrenia Models
- (2019) Urjita H. Shah et al. ACS Chemical Neuroscience
- Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5
- (2019) Amy N. Y. Chen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Emerging pharmacological therapies in fragile X syndrome and autism
- (2019) Hidenori Yamasue et al. CURRENT OPINION IN NEUROLOGY
- Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
- (2019) Kathy Sengmany et al. NEUROPHARMACOLOGY
- Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia
- (2019) Ferdinando Nicoletti et al. Frontiers in Psychiatry
- Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor
- (2019) Prashant C. Donthamsetti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
- (2019) Vanessa A Gutzeit et al. eLife
- Metabotropic glutamate receptor 5 (mGlu 5 )‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu 5 signaling in recombinant cells and neurons
- (2019) Shane D. Hellyer et al. JOURNAL OF NEUROCHEMISTRY
- The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures
- (2019) Benoit Girard et al. NEUROBIOLOGY OF DISEASE
- Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu5, Negative Allosteric Modulators
- (2019) Yuh-Jiin Ivy Jong et al. ACS Chemical Neuroscience
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
- (2019) Stephen P H Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites
- (2019) Karen J. Gregory et al. MOLECULAR PHARMACOLOGY
- Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo
- (2019) Amanda Acosta-Ruiz et al. NEURON
- The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
- (2019) Serena Boccella et al. Current Neuropharmacology
- The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans
- (2019) Katarina Varnäs et al. NEUROPHARMACOLOGY
- A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease
- (2019) Paula Maria Quaglio Bellozi et al. NEUROPHARMACOLOGY
- Conformational pathway provides unique sensitivity to a synaptic mGluR
- (2019) Chris H. Habrian et al. Nature Communications
- Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation
- (2018) Yong-jian Hu et al. ACTA PHARMACOLOGICA SINICA
- ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from ‘binge-like’ ethanol exposure in rats
- (2018) Marta Marszalek-Grabska et al. BEHAVIOURAL BRAIN RESEARCH
- Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction
- (2018) Alan J. Cross et al. BIOLOGICAL PSYCHIATRY
- A method for the quantification of biased signalling at constitutively active receptors
- (2018) David A Hall et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metabotropic glutamate receptor involvement in the pathophysiology of amyotrophic lateral sclerosis: new potential drug targets for therapeutic applications
- (2018) Giuseppe Battaglia et al. CURRENT OPINION IN PHARMACOLOGY
- Metabotropic glutamate receptors as targets for novel anxiolytics
- (2018) Francesco Ferraguti CURRENT OPINION IN PHARMACOLOGY
- Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology
- (2018) Cyril Goudet et al. CURRENT OPINION IN PHARMACOLOGY
- mGlu receptors as potential targets for novel antidepressants
- (2018) Shigeyuki Chaki et al. CURRENT OPINION IN PHARMACOLOGY
- Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4
- (2018) Claudia Volpi et al. Expert Opinion on Drug Discovery
- Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist
- (2018) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
- (2018) Maarten L. J. Doornbos et al. JOURNAL OF MEDICINAL CHEMISTRY
- Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
- (2018) Chelliah Selvam et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures
- (2018) John A. Christopher et al. JOURNAL OF MEDICINAL CHEMISTRY
- The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease
- (2018) Juliana G. Doria et al. JOURNAL OF NEUROCHEMISTRY
- Differential Pharmacology and Binding of mGlu2Receptor Allosteric Modulators
- (2018) Daniel E. O’Brien et al. MOLECULAR PHARMACOLOGY
- “Selective” Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5Allosteric Ligands
- (2018) Shane D. Hellyer et al. MOLECULAR PHARMACOLOGY
- 5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling
- (2018) Samy Murat et al. MOLECULAR PSYCHIATRY
- mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
- (2018) Ping Jun Zhu et al. NATURE NEUROSCIENCE
- Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist
- (2018) Zuzana Hajasova et al. NEUROPHARMACOLOGY
- mGlu 4 allosteric modulation for treating Parkinson's disease
- (2018) Delphine Charvin NEUROPHARMACOLOGY
- Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
- (2018) Luisa Di Menna et al. NEUROPHARMACOLOGY
- Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
- (2018) Bo Xing et al. NEUROPHARMACOLOGY
- Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat
- (2018) Sophie Lebourgeois et al. NEUROPHARMACOLOGY
- mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell
- (2018) Brandon D. Turner et al. NEUROPSYCHOPHARMACOLOGY
- The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands
- (2018) K. Gawel et al. PHYSIOLOGY & BEHAVIOR
- Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension
- (2018) Helena Domin et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
- (2018) Josephine Elia et al. Nature Communications
- Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs
- (2018) Chady Nasrallah et al. Scientific Reports
- mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism
- (2018) Xia Li et al. Scientific Reports
- Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
- (2018) Francesca Nardecchia et al. Frontiers in Neuroscience
- Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice
- (2018) Mark J. Benvenga et al. Frontiers in Pharmacology
- SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand
- (2018) Helen Farrants et al. ACS Chemical Biology
- Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 – present)
- (2018) Sylvain Celanire et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer
- (2018) Zhichao Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators
- (2018) Samantha E. Yohn et al. MOLECULAR PSYCHIATRY
- An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates
- (2018) Delphine Charvin et al. MOVEMENT DISORDERS
- Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
- (2018) Delphine Charvin et al. NATURE REVIEWS DRUG DISCOVERY
- Rescue of Fmr1 phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056
- (2018) Pamela R. Westmark et al. NEUROBIOLOGY OF DISEASE
- The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice
- (2018) Karolina Podkowa et al. NEUROPHARMACOLOGY
- Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
- (2018) Amélie S. Tora et al. NEUROPHARMACOLOGY
- Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction
- (2018) Daniel E. Felsing et al. PLoS One
- Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs
- (2018) Paulina Cieślik et al. Frontiers in Molecular Neuroscience
- In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator
- (2018) Anna R. Zuena et al. Frontiers in Pharmacology
- Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy
- (2018) Tyler J. Hanak et al. EXPERIMENTAL NEUROLOGY
- The Role of Extracellular Signal-Regulated Kinases (ERK) in the Regulation of mGlu5 Receptors in Neurons
- (2018) Dao-Zhong Jin et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Activated CaMKIIα Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization
- (2018) Christian R. Marks et al. MOLECULAR PHARMACOLOGY
- Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress
- (2018) Max E. Joffe et al. NEUROPHARMACOLOGY
- Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen
- (2018) Adam L. Halberstadt et al. PSYCHOPHARMACOLOGY
- Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5
- (2018) Ariel M. Zeleznikow-Johnston et al. Scientific Reports
- Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders
- (2018) Nicole M. Fisher et al. Frontiers in Molecular Neuroscience
- Group II Metabotropic Glutamate Receptors: Role in Pain Mechanisms and Pain Modulation
- (2018) Mariacristina Mazzitelli et al. Frontiers in Molecular Neuroscience
- Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
- (2018) Simona Federica Spampinato et al. Frontiers in Molecular Neuroscience
- Activation of peripheral group III metabotropic glutamate receptors inhibits pain transmission by decreasing neuronal excitability in the CFA-inflamed knee joint
- (2018) Eui Ho Park et al. NEUROSCIENCE LETTERS
- Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures
- (2017) Cameron S. Metcalf et al. EPILEPSIA
- Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling
- (2017) Gary Tresadern et al. Journal of Chemical Information and Modeling
- Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
- (2017) Delphine Charvin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
- (2017) Maarten L. J. Doornbos et al. JOURNAL OF MEDICINAL CHEMISTRY
- PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes
- (2017) Maxime Vergouts et al. JOURNAL OF NEUROCHEMISTRY
- Translational Pharmacology of the Metabotropic Glutamate 2 Receptor–Preferring Agonist LY2812223 in the Animal and Human Brain
- (2017) Christian C. Felder et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
- (2017) Aintzane García-Bea et al. JOURNAL OF PSYCHOPHARMACOLOGY
- The selective metabotropic glutamate receptor 5 antagonist mavoglurant (AFQ056) reduces the incidence of reflux episodes in dogs and patients with moderate to severe gastroesophageal reflux disease
- (2017) M.-L. Rouzade-Dominguez et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
- (2017) Francesco Fazio et al. NEUROPHARMACOLOGY
- Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery
- (2017) Kathy Sengmany et al. NEUROPHARMACOLOGY
- Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum
- (2017) Kari A. Johnson et al. NEUROPHARMACOLOGY
- Deficits in the extinction of ethanol-seeking behavior following chronic intermittent ethanol exposure are attenuated with positive allosteric modulation of mGlu5
- (2017) J.T. Gass et al. NEUROPHARMACOLOGY
- Selective and interactive effects of D 2 receptor antagonism and positive allosteric mGluR4 modulation on waiting impulsivity
- (2017) Sarah N. Isherwood et al. NEUROPHARMACOLOGY
- Neurochemical and behavioral studies on the 5-HT 1A -dependent antipsychotic action of the mGlu 4 receptor agonist LSP4-2022
- (2017) Monika Woźniak et al. NEUROPHARMACOLOGY
- Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results
- (2017) Eriene A Youssef et al. NEUROPSYCHOPHARMACOLOGY
- Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration
- (2017) Francesca Liberatore et al. NEUROSCIENCE
- Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain
- (2017) Stefanie L. Ritter-Makinson et al. NEUROSCIENCE
- Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus
- (2017) Isabella Panaccione et al. PHARMACOLOGICAL RESEARCH
- Molecular insights into allosteric modulation of Class C G protein-coupled receptors
- (2017) Katie Leach et al. PHARMACOLOGICAL RESEARCH
- Metabotropic glutamate receptors and neurodegenerative diseases
- (2017) Fabiola M. Ribeiro et al. PHARMACOLOGICAL RESEARCH
- Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling
- (2017) Ana Neto et al. Pigment Cell & Melanoma Research
- Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors
- (2017) Joshua Levitz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mGlu1 receptor as a drug target for treatment of substance use disorders: time to gather stones together?
- (2017) Olga A. Dravolina et al. PSYCHOPHARMACOLOGY
- mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease
- (2017) Khaled S. Abd-Elrahman et al. Science Signaling
- mGlu 7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome
- (2017) Rocco G. Gogliotti et al. Science Translational Medicine
- Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor
- (2017) Laura Pérez-Benito et al. STRUCTURE
- Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs
- (2017) Julie L. Engers et al. ACS Medicinal Chemistry Letters
- Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines
- (2017) Masahito Abe et al. ACS Medicinal Chemistry Letters
- Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
- (2017) Pauline Scholler et al. Nature Communications
- Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand
- (2017) James A. R. Dalton et al. Scientific Reports
- Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes
- (2017) Laura T. Haas et al. Cell Reports
- Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
- (2017) Junke Liu et al. eLife
- Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
- (2017) David Moreno Delgado et al. eLife
- Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
- (2017) Joan Font et al. eLife
- mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease
- (2017) Khaled S. Abd-Elrahman et al. Science Signaling
- Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk
- (2017) S M Saini et al. Translational Psychiatry
- Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators
- (2016) Karen J. Gregory et al. ACS Chemical Biology
- Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
- (2016) Colleen M. Niswender et al. ACS Chemical Neuroscience
- Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)
- (2016) Darren W. Engers et al. ACS Chemical Neuroscience
- Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (−/−) mice
- (2016) A. Ahnaou et al. BEHAVIOURAL BRAIN RESEARCH
- Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice
- (2016) Kristen K. Ade et al. BIOLOGICAL PSYCHIATRY
- Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
- (2016) Pedro M. Garcia-Barrantes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Re-exploration of the mGlu1 PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR
- (2016) Pedro M. Garcia-Barrantes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues
- (2016) Christina J Perry et al. BRITISH JOURNAL OF PHARMACOLOGY
- Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222
- (2016) Maarten L J Doornbos et al. BRITISH JOURNAL OF PHARMACOLOGY
- Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors
- (2016) Craig W. Lindsley et al. CHEMICAL REVIEWS
- Metabotropic Glutamate Receptors in Central Nervous System Diseases
- (2016) Anna V. Golubeva et al. CURRENT DRUG TARGETS
- The Role of Metabotropic Glutamate Receptor Genes in Schizophrenia
- (2016) Carlo Maj et al. Current Neuropharmacology
- Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats
- (2016) Evelyn Kahl et al. Current Neuropharmacology
- Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications
- (2016) Enza Palazzo et al. Current Neuropharmacology
- A Critical Role for Ubiquitination in the Endocytosis of Glutamate Receptors
- (2016) Ravinder Gulia et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia
- (2016) Ranjani Ponnazhagan et al. Journal of Neuroimmune Pharmacology
- Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses
- (2016) Karin R. Aubrey et al. JOURNAL OF PHYSIOLOGY-LONDON
- Synaptic ERK2 Phosphorylates and Regulates Metabotropic Glutamate Receptor 1 In Vitro and in Neurons
- (2016) Ju Hwan Yang et al. MOLECULAR NEUROBIOLOGY
- Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
- (2016) C Zussy et al. MOLECULAR PSYCHIATRY
- Mavoglurant in Parkinson's patients withl-Dopa-induced dyskinesias: Two randomized phase 2 studies
- (2016) Claudia Trenkwalder et al. MOVEMENT DISORDERS
- A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease
- (2016) François Tison et al. MOVEMENT DISORDERS
- Organization and functions of mGlu and GABAB receptor complexes
- (2016) Jean-Philippe Pin et al. NATURE
- Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors
- (2016) Joshua Levitz et al. NEURON
- Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men
- (2016) A. Ahnaou et al. NEUROPHARMACOLOGY
- Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
- (2016) Claudia Volpi et al. NEUROPHARMACOLOGY
- Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2
- (2016) L. Lundström et al. NEUROPHARMACOLOGY
- Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies
- (2016) Helena Domin et al. NEUROPHARMACOLOGY
- An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia
- (2016) Darrick T Balu et al. NEUROPSYCHOPHARMACOLOGY
- The mGluR2 Positive Allosteric Modulator, AZD8529 and Cue-Induced Relapse to Alcohol Seeking in Rats
- (2016) Eric Augier et al. NEUROPSYCHOPHARMACOLOGY
- Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats
- (2016) Kazuaki Kawaura et al. Pharmacological Reports
- The anti-absence effect of mGlu5 receptor amplification with VU0360172 is maintained during and after antiepileptogenesis
- (2016) Valerio D'Amore et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice
- (2016) Jun-Yeob Lee et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice
- (2016) Dorota Zolkowska et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression
- (2016) Justine M. Kent et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex
- (2016) Nikhil J. Pandya et al. PROTEOMICS
- Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats
- (2016) Xia Li et al. PSYCHOPHARMACOLOGY
- Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in rats
- (2016) Karolina Podkowa et al. PSYCHOPHARMACOLOGY
- AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study
- (2016) Robert E. Litman et al. SCHIZOPHRENIA RESEARCH
- Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia
- (2016) José L. Moreno et al. Science Signaling
- Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials
- (2016) Elizabeth Berry-Kravis et al. Science Translational Medicine
- Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network
- (2016) Valériane Tassin et al. Frontiers in Neural Circuits
- Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
- (2016) Andrew G. Eng et al. Nature Communications
- The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia
- (2016) Guy Griebel et al. Scientific Reports
- Chronic Pharmacological mGluR5 Inhibition Prevents Cognitive Impairment and Reduces Pathogenesis in an Alzheimer Disease Mouse Model
- (2016) Alison Hamilton et al. Cell Reports
- The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture
- (2016) Joohyeon Hong et al. Molecular Brain
- Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression
- (2016) Jorge A. Quiroz et al. JAMA Psychiatry
- Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia
- (2016) José L. Moreno et al. Science Signaling
- Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System
- (2016) Anna Pittaluga Frontiers in Pharmacology
- Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
- (2016) Xavier Gómez-Santacana et al. ACS Central Science
- Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells
- (2015) Tara Gelb et al. BIOCHEMICAL PHARMACOLOGY
- The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys
- (2015) Zuzana Justinova et al. BIOLOGICAL PSYCHIATRY
- Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia
- (2015) Bruce J. Kinon et al. BIOLOGICAL PSYCHIATRY
- Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
- (2015) Daniele Caprioli et al. BIOLOGICAL PSYCHIATRY
- Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core
- (2015) Pedro M. Garcia-Barrantes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabotropic glutamate receptor 5 upregulates surface NMDA receptor expression in striatal neurons via CaMKII
- (2015) Dao-Zhong Jin et al. BRAIN RESEARCH
- Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2
- (2015) A Farinha et al. BRITISH JOURNAL OF PHARMACOLOGY
- Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics
- (2015) Adam G Walker et al. CURRENT OPINION IN PHARMACOLOGY
- Anti-absence activity of mGlu1 and mGlu5 receptor enhancers and their interaction with a GABA reuptake inhibitor: Effect of local infusions in the somatosensory cortex and thalamus
- (2015) Valerio D'Amore et al. EPILEPSIA
- LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment
- (2015) Meng-Lin Li et al. EXPERIMENTAL NEUROLOGY
- Allosteric modulation of metabotropic glutamate receptors by chloride ions
- (2015) Amélie S. Tora et al. FASEB JOURNAL
- Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors
- (2015) Xavier Rovira et al. FASEB JOURNAL
- Functional Dissociation of Group III Metabotropic Glutamate Receptors Revealed by Direct Comparison between the Behavioral Profiles of Knockout Mouse Lines
- (2015) Hannelore Goddyn et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Mavoglurant (AFQ056) in combination with increased levodopa dosages in Parkinson's disease patients
- (2015) Rajeev Kumar et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics
- (2015) Pedro M. Garcia-Barrantes et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
- (2015) Julie L. Engers et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
- (2015) Andrew S. Felts et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
- (2015) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
- (2015) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)
- (2015) John A. Christopher et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
- (2015) Ken Uematsu et al. JOURNAL OF NEUROCHEMISTRY
- Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulatesl-DOPA-induced rotational behavior in a rodent model of Parkinson's disease
- (2015) Marie-Therese Fuzzati-Armentero et al. JOURNAL OF NEUROCHEMISTRY
- Mavoglurant in adolescents with fragile X syndrome: analysis of Clinical Global Impression-Improvement source data from a double-blind therapeutic study followed by an open-label, long-term extension study
- (2015) Donald B. Bailey et al. Journal of Neurodevelopmental Disorders
- Relative Contributions of Presystemic and Systemic Peptidases to Oral Exposure of a Novel Metabotropic Glutamate 2/3 Receptor Agonist (LY404039) After Oral Administration of Prodrug Pomaglumetad Methionil (LY2140023)
- (2015) William F. Annes et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies
- (2015) Hiba Salih et al. JOURNAL OF PSYCHOPHARMACOLOGY
- A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease
- (2015) Ralf Reilmann et al. MOVEMENT DISORDERS
- Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis
- (2015) Giuseppe Battaglia et al. NEUROBIOLOGY OF DISEASE
- Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test
- (2015) C.E.F. de Esch et al. NEUROBIOLOGY OF DISEASE
- The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease
- (2015) J.G. Doria et al. NEUROBIOLOGY OF DISEASE
- Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k
- (2015) Rikki Hullinger et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats
- (2015) Zong-yong Zhang et al. NEUROCHEMICAL RESEARCH
- Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents
- (2015) Jerri M. Rook et al. NEURON
- Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism
- (2015) Hannah A. Hathaway et al. NEUROPHARMACOLOGY
- Co-operative binding assay for the characterization of mGlu4 allosteric modulators
- (2015) Pekka Poutiainen et al. NEUROPHARMACOLOGY
- A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action
- (2015) Karolina Podkowa et al. NEUROPHARMACOLOGY
- Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
- (2015) Hanna Iderberg et al. NEUROPHARMACOLOGY
- Partial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
- (2015) Robert W Gould et al. NEUROPSYCHOPHARMACOLOGY
- Differential effects of protein phosphatases in the recycling of metabotropic glutamate receptor 5
- (2015) P.K. Mahato et al. NEUROSCIENCE
- Determination of the absolute configuration of phosphinic analogues of glutamate
- (2015) Bruno Commare et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics
- (2015) Elizabeth C. Carroll et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction
- (2015) Adam G. Walker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice
- (2015) M. Jenda et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Congenital stationary night blindness: An analysis and update of genotype–phenotype correlations and pathogenic mechanisms
- (2015) Christina Zeitz et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia
- (2015) Susana Conde-Ceide et al. ACS Medicinal Chemistry Letters
- Ca2+/Calmodulin-dependent protein Kinase II interacts with group I Metabotropic Glutamate and facilitates Receptor Endocytosis and ERK1/2 signaling: role of β-Amyloid
- (2015) Fitore Raka et al. Molecular Brain
- Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage
- (2015) Marta Motolese et al. Molecular Brain
- Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool
- (2015) Michiel van Wyk et al. PLOS BIOLOGY
- Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand
- (2015) Johannes Broichhagen et al. ACS Central Science
- mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats
- (2015) Abdallah Ahnaou et al. PLoS One
- Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics
- (2014) Hyekyung P. Cho et al. ACS Chemical Biology
- Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site
- (2014) Karen J. Gregory et al. ACS Chemical Neuroscience
- A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and Human Receptors
- (2014) Hyekyung P. Cho et al. ACS Chemical Neuroscience
- Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7
- (2014) Nidhi Jalan-Sakrikar et al. ACS Chemical Neuroscience
- AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization
- (2014) Ivo Vranesic et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs
- (2014) Cody J. Wenthur et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A double-blind, placebo-controlled comparator study of LY2140023 monohydrate in patients with schizophrenia
- (2014) AnnCatherine M Downing et al. BMC Psychiatry
- mGlu2 receptor-mediated modulation of conditioned avoidance behavior in rats
- (2014) Anton A.H.P. Megens et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Chronic administration of antipsychotics attenuates ongoing and ketamine-induced increases in cortical γ oscillations
- (2014) Paul M. Anderson et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior
- (2014) Christine E. Gee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
- (2014) José María Cid et al. JOURNAL OF MEDICINAL CHEMISTRY
- Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines
- (2014) Saurabh Pandey et al. JOURNAL OF NEUROCHEMISTRY
- Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS
- (2014) S. Yin et al. JOURNAL OF NEUROSCIENCE
- Intracellular mGluR5 Can Mediate Synaptic Plasticity in the Hippocampus
- (2014) C. A. Purgert et al. JOURNAL OF NEUROSCIENCE
- Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse
- (2014) S H Kim et al. MOLECULAR PSYCHIATRY
- The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model
- (2014) Erwan Bezard et al. MOVEMENT DISORDERS
- Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
- (2014) Andrew S. Doré et al. NATURE
- An allosteric modulator to control endogenous G protein-coupled receptors with light
- (2014) Silvia Pittolo et al. Nature Chemical Biology
- Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
- (2014) Li Xue et al. Nature Chemical Biology
- Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo
- (2014) Šárka Techlovská et al. NEUROPHARMACOLOGY
- Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats
- (2014) V. D'Amore et al. NEUROPHARMACOLOGY
- Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice
- (2014) Francesco Fazio et al. NEUROPHARMACOLOGY
- Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles
- (2014) Jerri M Rook et al. NEUROPSYCHOPHARMACOLOGY
- Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress
- (2014) Klaus V Wagner et al. NEUROPSYCHOPHARMACOLOGY
- Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity
- (2014) Jérôme AJ Becker et al. NEUROPSYCHOPHARMACOLOGY
- Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
- (2014) David J. Loane et al. Neurotherapeutics
- Group III mGlu Receptor Agonist, ACPT-I, Exerts Potential Neuroprotective Effects In Vitro and In Vivo
- (2014) Helena Domin et al. NEUROTOXICITY RESEARCH
- Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas
- (2014) T Gelb et al. ONCOGENE
- mGluR1-Mediated Excitation of Cerebellar GABAergic Interneurons Requires Both G Protein-Dependent and Src–ERK1/2-Dependent Signaling Pathways
- (2014) Hideo Kubota et al. PLoS One
- The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
- (2014) Neil C. Lax et al. PLoS One
- Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
- (2014) H. Wu et al. SCIENCE
- 2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice
- (2014) Réno M. Gandhi et al. Frontiers in Cellular Neuroscience
- Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning
- (2013) D. Klakotskaia et al. BEHAVIOURAL BRAIN RESEARCH
- The effects of mGlu7 receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains
- (2013) Richard M. O’Connor et al. BEHAVIOURAL PHARMACOLOGY
- Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice
- (2013) Aubin Michalon et al. BIOLOGICAL PSYCHIATRY
- Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators
- (2013) Holger Kubas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators
- (2013) Eunhee Chae et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety
- (2013) Andrew S. Felts et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia
- (2013) David H Adams et al. BMC Psychiatry
- The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4receptors in rodents
- (2013) Anna Sławińska et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease
- (2013) JG Doria et al. BRITISH JOURNAL OF PHARMACOLOGY
- Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor
- (2013) John O. DiRaddo et al. GENE
- Agonist-dependent Signaling by Group I Metabotropic Glutamate Receptors Is Regulated by Association with Lipid Domains
- (2013) Ranju Kumari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extracellular Calcium Modulates Actions of Orthosteric and Allosteric Ligands on Metabotropic Glutamate Receptor 1α
- (2013) Jason Y. Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Metabotropic Glutamate Receptor 7 (mGluR7) Internalization and Surface Expression by Ser/Thr Protein Phosphatase 1
- (2013) Young Ho Suh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca2+in neurons
- (2013) Dao-Zhong Jin et al. JOURNAL OF NEUROCHEMISTRY
- Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions
- (2013) Francesca Rossi et al. JOURNAL OF NEUROPHYSIOLOGY
- Phosphorylation and Feedback Regulation of Metabotropic Glutamate Receptor 1 by Calcium/Calmodulin-Dependent Protein Kinase II
- (2013) D.-Z. Jin et al. JOURNAL OF NEUROSCIENCE
- Simultaneous Monitoring of Presynaptic Transmitter Release and Postsynaptic Receptor Trafficking Reveals an Enhancement of Presynaptic Activity in Metabotropic Glutamate Receptor-Mediated Long-Term Depression
- (2013) W. Xu et al. JOURNAL OF NEUROSCIENCE
- Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
- (2013) B. Vilar et al. JOURNAL OF NEUROSCIENCE
- Stimulation of Metabotropic Glutamate (mGlu) 2 Receptor and Blockade of mGlu1 Receptor Improve Social Memory Impairment Elicited by MK-801 in Rats
- (2013) Hirohiko Hikichi et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors
- (2013) Jia Cheng et al. JOURNAL OF PHYSIOLOGY-LONDON
- AFQ056 in Parkinson patients with levodopa-induced dyskinesia: 13-week, randomized, dose-finding study
- (2013) Fabrizio Stocchi et al. MOVEMENT DISORDERS
- Optogenetic pharmacology for control of native neuronal signaling proteins
- (2013) Richard H Kramer et al. NATURE NEUROSCIENCE
- Optical control of metabotropic glutamate receptors
- (2013) Joshua Levitz et al. NATURE NEUROSCIENCE
- Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
- (2013) Ji Won Um et al. NEURON
- Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors
- (2013) B.D. Harvey et al. NEUROPHARMACOLOGY
- Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology
- (2013) Markus Fendt et al. NEUROPHARMACOLOGY
- The two faces of the pharmacological interaction of mGlu2 and 5-HT2A – Relevance of receptor heterocomplexes and interaction through functional brain pathways
- (2013) Hannah K. Delille et al. NEUROPHARMACOLOGY
- Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target
- (2013) Sophie Parmentier-Batteur et al. NEUROPHARMACOLOGY
- Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice
- (2013) José L. Moreno et al. NEUROSCIENCE LETTERS
- Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
- (2013) E. Doumazane et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans
- (2013) Thomas M. Keck et al. PSYCHOPHARMACOLOGY
- The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats
- (2012) Nikolaos Pitsikas et al. BEHAVIOURAL BRAIN RESEARCH
- Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
- (2012) Ilse Gantois et al. BEHAVIOURAL BRAIN RESEARCH
- A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats
- (2012) Agnieszka Pałucha-Poniewiera et al. BEHAVIOURAL BRAIN RESEARCH
- Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity
- (2012) Jerri M. Rook et al. BIOLOGICAL PSYCHIATRY
- Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
- (2012) Douglas J. Sheffler et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
- (2012) C Ullmer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4
- (2012) RJ Slack et al. BRITISH JOURNAL OF PHARMACOLOGY
- Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease
- (2012) Matthew J Betts et al. BRITISH JOURNAL OF PHARMACOLOGY
- Blocking glutamate-mediated signalling inhibits human melanoma growth and migration
- (2012) Zhiqi Song et al. EXPERIMENTAL DERMATOLOGY
- Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders
- (2012) Sylvain Célanire et al. Expert Opinion on Drug Discovery
- A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential
- (2012) Cyril Goudet et al. FASEB JOURNAL
- Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice
- (2012) Mao Horio et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments inFmr1KO mice
- (2012) M. F. Vinueza Veloz et al. GENES BRAIN AND BEHAVIOR
- Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
- (2012) Jose María Cid et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase- Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia
- (2012) L. C. Gregg et al. JOURNAL OF NEUROSCIENCE
- PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A
- (2012) S. J. Ko et al. JOURNAL OF NEUROSCIENCE
- In Vivo Measurement of the Affinity and Density of Metabotropic Glutamate Receptor Subtype 1 in Rat Brain Using 18F-FITM in Small-Animal PET
- (2012) T. Yamasaki et al. JOURNAL OF NUCLEAR MEDICINE
- A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex
- (2012) Karine Abitbol et al. JOURNAL OF PHYSIOLOGY-LONDON
- Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats
- (2012) Philip L Johnson et al. JOURNAL OF PSYCHOPHARMACOLOGY
- De novo mutations revealed by whole-exome sequencing are strongly associated with autism
- (2012) Stephan J. Sanders et al. NATURE
- Preso1 dynamically regulates group I metabotropic glutamate receptors
- (2012) Jia-Hua Hu et al. NATURE NEUROSCIENCE
- HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
- (2012) Mitsumasa Kurita et al. NATURE NEUROSCIENCE
- Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
- (2012) Aubin Michalon et al. NEURON
- Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist
- (2012) Lydia Hanna et al. NEUROPHARMACOLOGY
- Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats
- (2012) V. D'Amore et al. NEUROPHARMACOLOGY
- An agonist at glutamate and dopamine D2 receptors, LY404039
- (2012) Philip Seeman NEUROPHARMACOLOGY
- In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat
- (2012) Gary Gilmour et al. NEUROPHARMACOLOGY
- Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
- (2012) Celia Goeldner et al. NEUROPHARMACOLOGY
- Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors
- (2012) Shen Yin et al. NEUROPHARMACOLOGY
- Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease
- (2012) M. Amalric et al. NEUROPHARMACOLOGY
- The mGlu5 positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat
- (2012) Francois Gastambide et al. NEUROPHARMACOLOGY
- Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
- (2012) Z.A. Hughes et al. NEUROPHARMACOLOGY
- CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography
- (2012) Rebecca A. Wright et al. NEUROPHARMACOLOGY
- Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius
- (2012) X.H. Liu et al. NEUROSCIENCE
- Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model
- (2012) Ming-Hong Hsieh et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Deleterious GRM1 Mutations in Schizophrenia
- (2012) Mohammed Akli Ayoub et al. PLoS One
- G-protein-mediated inhibition of the Trp channel TRPM1 requires the G dimer
- (2012) Y. Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
- (2012) D. El Moustaine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator
- (2012) Lucas R. Watterson et al. PSYCHOPHARMACOLOGY
- Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine
- (2012) Nicholas E. Clifton et al. PSYCHOPHARMACOLOGY
- Differential modulation of thresholds for intracranial self-stimulation by mGlu5 positive and negative allosteric modulators: implications for effects on drug self-administration
- (2012) Richard M. Cleva Frontiers in Pharmacology
- Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration
- (2012) Peter R. Kufahl et al. Frontiers in Pharmacology
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats
- (2011) Amine Bahi et al. ADDICTION BIOLOGY
- Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease
- (2011) F. Zerbib et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Metabotropic Glutamate Receptor 5 Antagonism with Fenobam
- (2011) Michael C. Montana et al. ANESTHESIOLOGY
- mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.
- (2011) Richard M. Cleva et al. BEHAVIORAL NEUROSCIENCE
- Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges
- (2011) Robert M. Duvoisin et al. BEHAVIOURAL BRAIN RESEARCH
- “Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology
- (2011) Michael R. Wood et al. BIOCHEMISTRY
- Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys
- (2011) G. J. Masilamoni et al. BRAIN
- Defining protein kinase/phosphatase isoenzymic regulation of mGlu5receptor-stimulated phospholipase C and Ca2+responses in astrocytes
- (2011) SJ Bradley et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators
- (2011) L Lundström et al. BRITISH JOURNAL OF PHARMACOLOGY
- Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs
- (2011) Miguel Fribourg et al. CELL
- Depression of Release by mGluR8 Alters Ca2+ Dependence of Release Machinery
- (2011) Evelyn Erdmann et al. CEREBRAL CORTEX
- Activation of Intracellular Metabotropic Glutamate Receptor 5 in Striatal Neurons Leads to Up-regulation of Genes Associated with Sustained Synaptic Transmission Including Arc/Arg3.1 Protein
- (2011) Vikas Kumar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Multicenter, Inpatient, Phase 2, Double-Blind, Placebo-Controlled Dose-Ranging Study of LY2140023 Monohydrate in Patients With DSM-IV Schizophrenia
- (2011) Bruce J. Kinon et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Discovery, Synthesis, and Structure−Activity Relationship Development of a Series ofN-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats
- (2011) Darren W. Engers et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
- (2011) Brice Campo et al. JOURNAL OF NEUROGENETICS
- The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?
- (2011) S. J. Sukoff Rizzo et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Quantitative Analysis Reveals Multiple Mechanisms of Allosteric Modulation of the mGlu5 Receptor in Rat Astroglia
- (2011) S. J. Bradley et al. MOLECULAR PHARMACOLOGY
- Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma
- (2011) Todd D Prickett et al. NATURE GENETICS
- On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice
- (2011) J.M. Wierońska et al. NEUROPHARMACOLOGY
- Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt/GSK-3β Pathway in Adult Rat Prefrontal Cortex
- (2011) Dong Xi et al. NEUROPSYCHOPHARMACOLOGY
- Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator
- (2011) Francois Gastambide et al. NEUROPSYCHOPHARMACOLOGY
- Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain
- (2011) Hua Wang et al. NEUROREPORT
- Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues
- (2011) M. Julio-Pieper et al. PHARMACOLOGICAL REVIEWS
- Clustered Coding Variants in the Glutamate Receptor Complexes of Individuals with Schizophrenia and Bipolar Disorder
- (2011) René A. W. Frank et al. PLoS One
- Reduced cAMP, Akt Activation and p65-c-Rel Dimerization: Mechanisms Involved in the Protective Effects of mGluR3 Agonists in Cultured Astrocytes
- (2011) Daniela Durand et al. PLoS One
- mGluR5-Antagonist Mediated Reversal of Elevated Stereotyped, Repetitive Behaviors in the VPA Model of Autism
- (2011) Mili V. Mehta et al. PLoS One
- Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia
- (2011) Joanna M. Wierońska et al. PSYCHOPHARMACOLOGY
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology
- (2010) Alexis S. Hammond et al. ACS Chemical Neuroscience
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
- (2010) Colleen M. Niswender et al. Annual Review of Pharmacology and Toxicology
- Acute pharmacological modulation of mGluR8 reduces measures of anxiety
- (2010) Robert M. Duvoisin et al. BEHAVIOURAL BRAIN RESEARCH
- Alcohol-Induced Neurodegeneration, Suppression of Transforming Growth Factor-β, and Cognitive Impairment in Rats: Prevention by Group II Metabotropic Glutamate Receptor Activation
- (2010) Andrea Cippitelli et al. BIOLOGICAL PSYCHIATRY
- Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain
- (2010) Masayuki Fujinaga et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)
- (2010) Darren W. Engers et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists
- (2010) Thomas J. Woltering et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Effects of early and delayed treatment with an mGluR5 antagonist on motor impairment, nigrostriatal damage and neuroinflammation in a rodent model of Parkinson's disease
- (2010) G. Ambrosi et al. BRAIN RESEARCH BULLETIN
- Integrated Synthetic, Pharmacological, and Computational Investigation of cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Enantiomers As Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4
- (2010) Christo Christov et al. ChemMedChem
- Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents
- (2010) Hirohiko Hikichi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice
- (2010) Hirohiko Hikichi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization
- (2010) Siân M. Lennon et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Metabotropic glutamate receptor 7: At the interface of cognition and emotion
- (2010) Richard M. O'Connor et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455
- (2010) Stephen P East et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
- (2010) Etienne Doumazane et al. FASEB JOURNAL
- The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation
- (2010) Andrew C. Emery et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage
- (2010) Slavianka G Moyanova et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on l-DOPA-induced dyskinesia
- (2010) Andrzej Dekundy et al. JOURNAL OF NEURAL TRANSMISSION
- Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain
- (2010) Naresh Kumar et al. JOURNAL OF NEUROCHEMISTRY
- Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease
- (2010) F. M. Ribeiro et al. JOURNAL OF NEUROSCIENCE
- Effects of a Positive Allosteric Modulator of Group II Metabotropic Glutamate Receptors, LY487379, on Cognitive Flexibility and Impulsive-Like Responding in Rats
- (2010) A. Nikiforuk et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity
- (2010) A. L. Rodriguez et al. MOLECULAR PHARMACOLOGY
- Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies -Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective
- (2010) F. Caraci et al. MOLECULAR PHARMACOLOGY
- Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation
- (2010) Francesca Fallarino et al. NATURE MEDICINE
- Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH-impedance study in healthy subjects
- (2010) F. Zerbib et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
- (2010) Joanna M. Wierońska et al. NEUROPHARMACOLOGY
- A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design
- (2010) Francine C. Acher et al. NEUROPHARMACOLOGY
- Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration
- (2010) Sophie Parmentier-Batteur et al. NEUROPHARMACOLOGY
- The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats
- (2010) Xinchun Jin et al. NEUROPSYCHOPHARMACOLOGY
- Effect of CFMTI, an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity, on Fos expression in regions of the brain related to schizophrenia
- (2010) G. Suzuki et al. NEUROSCIENCE
- Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation
- (2010) E.A. Hackler et al. NEUROSCIENCE
- Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease
- (2010) Yolanda D. Black et al. NEUROSCIENCE LETTERS
- Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation
- (2010) Alexander A Nicodemo et al. Molecular Brain
- Metabotropic Glutamate Receptor 5 Activity in the Nucleus Accumbens Is Required for the Maintenance of Ethanol Self-Administration in a Rat Genetic Model of High Alcohol Intake
- (2009) Joyce Besheer et al. BIOLOGICAL PSYCHIATRY
- Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders
- (2009) Satoru Ito et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- l-Serine-O-phosphate in the central nervous system
- (2009) Jordan E. Antflick et al. BRAIN RESEARCH
- Molecular basis for amino acid sensing by family C G-protein-coupled receptors
- (2009) P Wellendorph et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist3H-HYDIA
- (2009) Linda Lundström et al. ChemMedChem
- Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism
- (2009) Corinne Beurrier et al. FASEB JOURNAL
- The effect of mGlu8deficiency in animal models of psychiatric diseases
- (2009) M. Fendt et al. GENES BRAIN AND BEHAVIOR
- A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease
- (2009) C Keywood et al. GUT
- Intracellular Metabotropic Glutamate Receptor 5 (mGluR5) Activates Signaling Cascades Distinct from Cell Surface Counterparts
- (2009) Yuh-Jiin I. Jong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
- Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)
- (2009) Darren W. Engers et al. JOURNAL OF MEDICINAL CHEMISTRY
- Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson’s disease treatment
- (2009) Dario Cuomo et al. JOURNAL OF NEUROCHEMISTRY
- Proteomic analysis reveals novel binding partners of metabotropic glutamate receptor 1
- (2009) Anna Francesconi et al. JOURNAL OF NEUROCHEMISTRY
- Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells
- (2009) Nuria Cabello et al. JOURNAL OF NEUROCHEMISTRY
- Regulation of Group I Metabotropic Glutamate Receptor Trafficking and Signaling by the Caveolar/Lipid Raft Pathway
- (2009) A. Francesconi et al. JOURNAL OF NEUROSCIENCE
- mGluR5 Has a Critical Role in Inhibitory Learning
- (2009) J. Xu et al. JOURNAL OF NEUROSCIENCE
- Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In Vivo Activity of Allosteric mGluR1 Antagonists
- (2009) Gentaroh Suzuki et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Unique Antipsychotic Activities of the Selective Metabotropic Glutamate Receptor 1 Allosteric Antagonist 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
- (2009) A. Satow et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine
- (2009) M. C. Montana et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
- (2009) Elissa White et al. MOLECULAR ENDOCRINOLOGY
- Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7
- (2009) C. M. Niswender et al. MOLECULAR PHARMACOLOGY
- Regulation of Group II Metabotropic Glutamate Receptors by G Protein-Coupled Receptor Kinases: mGlu2 Receptors Are Resistant to Homologous Desensitization
- (2009) L. Iacovelli et al. MOLECULAR PHARMACOLOGY
- Activation of mGlu2/3 Metabotropic Glutamate Receptors Negatively Regulates the Stimulation of Inositol Phospholipid Hydrolysis Mediated by 5-Hydroxytryptamine2A Serotonin Receptors in the Frontal Cortex of Living Mice
- (2009) G. Molinaro et al. MOLECULAR PHARMACOLOGY
- The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning
- (2009) Wolfgang Jacob et al. NEUROPHARMACOLOGY
- Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one
- (2009) Junko Fukuda et al. NEUROPHARMACOLOGY
- Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge
- (2009) Matthew J. Fell et al. NEUROPHARMACOLOGY
- Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism
- (2009) Xia Li et al. NEUROPSYCHOPHARMACOLOGY
- Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP
- (2009) Jill L Silverman et al. NEUROPSYCHOPHARMACOLOGY
- Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia
- (2009) Hideyuki Yoshioka et al. NEUROSCIENCE LETTERS
- TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade
- (2009) C. Koike et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of protein kinase C epsilon (PKCɛ) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell
- (2009) Justin T. Gass et al. PSYCHOPHARMACOLOGY
- Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling
- (2009) H. Wang et al. SCIENCE
- Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
- (2008) Colleen M. Niswender et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
- (2008) Thomas J. Woltering et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An Engineered Protein Tag for Multiprotein Labeling in Living Cells
- (2008) Arnaud Gautier et al. CHEMISTRY & BIOLOGY
- Molecule of the Month
- (2008) Evan Lebois CURRENT TOPICS IN MEDICINAL CHEMISTRY
- The mGlu4 receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu6 receptors
- (2008) Donald Beqollari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep–wake architecture
- (2008) Abdellah Ahnaou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals
- (2008) Osei B. Ansah et al. EXPERIMENTAL NEUROLOGY
- RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors
- (2008) Angela Seebahn et al. FEBS LETTERS
- Activated Nuclear Metabotropic Glutamate Receptor mGlu5 Couples to Nuclear Gq/11Proteins to Generate Inositol 1,4,5-Trisphosphate-mediated Nuclear Ca2+Release
- (2008) Vikas Kumar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ADX47273 [S-(4-Fluoro-phenyl)- -methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities
- (2008) F. Liu et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site
- (2008) B. A. Rowe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
- (2008) M. J. Fell et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
- (2008) Gül Dölen et al. JOURNAL OF PHYSIOLOGY-LONDON
- Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
- (2008) C. M. Niswender et al. MOLECULAR PHARMACOLOGY
- Identification of a serotonin/glutamate receptor complex implicated in psychosis
- (2008) Javier González-Maeso et al. NATURE
- PICK1 uncoupling from mGluR7a causes absence-like seizures
- (2008) Federica Bertaso et al. NATURE NEUROSCIENCE
- Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells
- (2008) Douglas J. Sheffler et al. NEUROPHARMACOLOGY
- Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents
- (2008) A. Pałucha-Poniewiera et al. NEUROPHARMACOLOGY
- Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells
- (2008) Jiri Kumpost et al. NEUROPHARMACOLOGY
- Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors
- (2008) Enza Palazzo et al. NEUROPHARMACOLOGY
- mGluR5 Antagonism Attenuates Methamphetamine Reinforcement and Prevents Reinstatement of Methamphetamine-Seeking Behavior in Rats
- (2008) Justin T Gass et al. NEUROPSYCHOPHARMACOLOGY
- The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice
- (2008) U.H. Schröder et al. NEUROSCIENCE
- Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082
- (2008) M SALLING et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
- (2008) J. H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
- (2008) Donna M. Platt et al. PSYCHOPHARMACOLOGY
- mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo
- (2007) Bichoy H. Gabra et al. BRAIN RESEARCH
- Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats
- (2007) Chang Z. Zhu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- mGlu4 potentiation of K2P2.1 is dependant on C-terminal dephosphorylation
- (2007) Stuart M. Cain et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis
- (2007) F. Matrisciano et al. NEUROPHARMACOLOGY
- Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures
- (2007) R.T. Ngomba et al. NEUROPHARMACOLOGY
- Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain
- (2007) Cyril Goudet et al. PAIN
- Characterization of [3H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections
- (2003) Vincent Mutel et al. JOURNAL OF NEUROCHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started