An allosteric modulator to control endogenous G protein-coupled receptors with light

Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

(2013) Laura Nevola et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optical Control of TRPV1 Channels

(2013) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor

(2013) Alwin Reiter et al.   BIOCHEMISTRY

Optogenetic pharmacology for control of native neuronal signaling proteins

(2013) Richard H Kramer et al.   NATURE NEUROSCIENCE

Optical control of metabotropic glutamate receptors

(2013) Joshua Levitz et al.   NATURE NEUROSCIENCE

Azo-Propofols: Photochromic Potentiators of GABAAReceptors

(2012) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid optical control of nociception with an ion-channel photoswitch

(2012) Alexandre Mourot et al.   NATURE METHODS

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

(2011) Arup K. Ghose et al.   ACS Chemical Neuroscience

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

“Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

(2011) Michael R. Wood et al.   BIOCHEMISTRY

Discovery, Synthesis, and Structure−Activity Relationship Development of a Series ofN-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats

(2011) Darren W. Engers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Remotely Triggerable Drug Delivery Systems

(2010) Brian P. Timko et al.   ADVANCED MATERIALS

Light- and drug-activated G-protein-coupled receptors to control intracellular signalling

(2010) Olivia A. Masseck et al.   EXPERIMENTAL PHYSIOLOGY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Is Pharma Running Out of Brainy Ideas?

(2010) G. Miller   SCIENCE

Photochromic Blockers of Voltage-Gated Potassium Channels

(2009) Matthew���R. Banghart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Optical Switches for Remote and Noninvasive Control of Cell Signaling

(2008) P. Gorostiza et al.   SCIENCE