A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

Dimers and beyond: The functional puzzles of class C GPCRs

(2011) Julie Kniazeff et al.   PHARMACOLOGY & THERAPEUTICS

The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor

(2011) Guy Servant et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease

(2010) Susan Duty   BRITISH JOURNAL OF PHARMACOLOGY

Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization

(2010) Siân M. Lennon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

(2010) Chelliah Selvam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular basis for amino acid sensing by family C G-protein-coupled receptors

(2009) P Wellendorph et al.   BRITISH JOURNAL OF PHARMACOLOGY

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism

(2009) Corinne Beurrier et al.   FASEB JOURNAL

Group III mGlu receptor agonist, ACPT-I, attenuates morphine-withdrawal symptoms after peripheral administration in mice

(2009) Agnieszka Pałucha-Poniewiera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

(2008) Johannes Antony et al.   FASEB JOURNAL

Depression of excitatory transmission at PF-PC synapse by group III metabotropic glutamate receptors is provided exclusively by mGluR4 in the rodent cerebellar cortex

(2008) Karine Abitbol et al.   JOURNAL OF NEUROCHEMISTRY

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY