Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
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Title
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
Authors
Keywords
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Journal
eLife
Volume 8, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2019-06-07
DOI
10.7554/elife.45116
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Related references
Note: Only part of the references are listed.- Structural insights into the activation of metabotropic glutamate receptors
- (2019) Antoine Koehl et al. NATURE
- Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement
- (2019) Eugene O. Grushevskyi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Molecular Basis of G Protein–Coupled Receptor Activation
- (2018) William I. Weis et al. Annual Review of Biochemistry
- Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels
- (2018) Chris Dockendorff et al. BIOCHEMISTRY
- Differential Pharmacology and Binding of mGlu2Receptor Allosteric Modulators
- (2018) Daniel E. O’Brien et al. MOLECULAR PHARMACOLOGY
- Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert
- (2018) Andreas Reiner et al. NEURON
- CCR5 adopts three homodimeric conformations that control cell surface delivery
- (2018) Jun Jin et al. Science Signaling
- GPCRs and Signal Transducers: Interaction Stoichiometry
- (2018) Vsevolod V. Gurevich et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Dynamic tuneable G protein-coupled receptor monomer-dimer populations
- (2018) Patricia M. Dijkman et al. Nature Communications
- CCR5 adopts three homodimeric conformations that control cell surface delivery
- (2018) Jun Jin et al. Science Signaling
- Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule
- (2018) Michael P. Bokoch et al. BIOCHEMISTRY
- Structural insights into G-protein-coupled receptor allostery
- (2018) David M. Thal et al. NATURE
- Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
- (2018) Amélie S. Tora et al. NEUROPHARMACOLOGY
- Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics
- (2018) Thor C. Møller et al. Scientific Reports
- Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
- (2018) Matthieu Masureel et al. Nature Chemical Biology
- Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
- (2017) G. Glenn Gregorio et al. NATURE
- A kinetic view of GPCR allostery and biased agonism
- (2017) J Robert Lane et al. Nature Chemical Biology
- Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders
- (2017) Daniel J. Foster et al. NEURON
- Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
- (2017) Francesco Fazio et al. NEUROPHARMACOLOGY
- Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor
- (2017) Laura Pérez-Benito et al. STRUCTURE
- Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging
- (2017) Qinsi Zheng et al. Chemical Science
- Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
- (2017) David A. Sykes et al. Nature Communications
- An engineered opsin monomer scrambles phospholipids
- (2017) Kalpana Pandey et al. Scientific Reports
- Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222
- (2016) Maarten L J Doornbos et al. BRITISH JOURNAL OF PHARMACOLOGY
- Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors
- (2016) Craig W. Lindsley et al. CHEMICAL REVIEWS
- Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
- (2016) Brian T. DeVree et al. NATURE
- Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors
- (2016) Joshua Levitz et al. NEURON
- The role of kinetic context in apparent biased agonism at GPCRs
- (2016) Carmen Klein Herenbrink et al. Nature Communications
- Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors
- (2015) Xavier Rovira et al. FASEB JOURNAL
- Conformational dynamics of a class C G-protein-coupled receptor
- (2015) Reza Vafabakhsh et al. NATURE
- Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia
- (2015) Francesco Fazio et al. Scientific Reports
- Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
- (2014) Andrew S. Doré et al. NATURE
- Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
- (2014) Li Xue et al. Nature Chemical Biology
- Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes
- (2014) Signe Mathiasen et al. NATURE METHODS
- Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
- (2014) H. Wu et al. SCIENCE
- Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
- (2014) Linnea Olofsson et al. Nature Communications
- Small-Molecule Photostabilizing Agents are Modifiers of Lipid Bilayer Properties
- (2013) Jose L. Alejo et al. BIOPHYSICAL JOURNAL
- Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
- (2013) E. Doumazane et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity
- (2012) Jerri M. Rook et al. BIOLOGICAL PSYCHIATRY
- Actions of Xanthurenic Acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus
- (2012) C.S. Copeland et al. NEUROPHARMACOLOGY
- Effect of channel mutations on the uptake and release of the retinal ligand in opsin
- (2012) R. Piechnick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
- (2012) D. El Moustaine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1
- (2012) V. Hlavackova et al. Science Signaling
- Comparative Fluorescence Resonance Energy Transfer Analysis of Metabotropic Glutamate Receptors
- (2011) Masataka Yanagawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Probing cellular protein complexes using single-molecule pull-down
- (2011) Ankur Jain et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
- (2010) Colleen M. Niswender et al. Annual Review of Pharmacology and Toxicology
- Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay
- (2010) Helgi I. Ingólfsson et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
- (2010) Etienne Doumazane et al. FASEB JOURNAL
- Metabotropic glutamate receptors: From the workbench to the bedside
- (2010) F. Nicoletti et al. NEUROPHARMACOLOGY
- Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
- (2009) Juan José Fung et al. EMBO JOURNAL
- Pentobarbital Produces Activation and Block of α1β2γ2SGABAAReceptors in Rapidly Perfused Whole Cells and Membrane Patches: Divergent Results Can Be Explained by Pharmacokinetics
- (2009) Kevin J. Gingrich et al. JOURNAL OF GENERAL PHYSIOLOGY
- Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization
- (2009) P. Marcaggi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural diversity of G protein-coupled receptors and significance for drug discovery
- (2008) Malin C. Lagerström et al. NATURE REVIEWS DRUG DISCOVERY
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