Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

(2010) Thomas J. Woltering et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies  -Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

(2010) F. Caraci et al.   MOLECULAR PHARMACOLOGY

Locomotor reactivity to a novel environment and sensitivity to MK-801 in five strains of mice

(2009) Mikhail Kalinichev et al.   BEHAVIOURAL PHARMACOLOGY

Emerging role of glutamate in the pathophysiology of major depressive disorder

(2009) Kenji Hashimoto   BRAIN RESEARCH REVIEWS

Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7

(2009) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons

(2009) Giuseppe Battaglia et al.   PLoS One

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression

(2009) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression

(2008) Anton Y. Bespalov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

(2008) W. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA