The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

(2013) Vincent Degos et al.   ANNALS OF NEUROLOGY

ADX71441, a novel, potent and selective positive allosteric modulator of the GABABreceptor, shows efficacy in rodent models of overactive bladder

(2013) M Kalinichev et al.   BRITISH JOURNAL OF PHARMACOLOGY

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

(2012) Matthew J Betts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamate Receptors as Therapeutic Targets for Parkinsons Disease

(2012) Kari Johnson et al.   CNS & Neurological Disorders-Drug Targets

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators

(2012) Ralf Mueller et al.   JOURNAL OF MOLECULAR MODELING

Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: Ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex

(2012) James Bogenpohl et al.   NEUROPHARMACOLOGY

Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors

(2012) Shen Yin et al.   NEUROPHARMACOLOGY

Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia

(2012) Khaled-Ezaheir Bennouar et al.   NEUROPHARMACOLOGY

Regulation of microglia effector functions by tumor necrosis factor signaling

(2011) Ashley S. Harms et al.   GLIA

Discovery, Synthesis, and Structure−Activity Relationship Development of a Series ofN-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats

(2011) Darren W. Engers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, Synthesis, and Structure–Activity Relationship Development of a Series ofN-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model

(2011) Carrie K. Jones et al.   JOURNAL OF MEDICINAL CHEMISTRY

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

(2010) Stephen P. East et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism

(2009) Corinne Beurrier et al.   FASEB JOURNAL

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY