Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice

(2012) Mao Horio et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Deficits in social cognition: a marker for psychiatric disorders?

(2011) Birgit Derntl et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders

(2011) Richard M. Cleva et al.   MOLECULES

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt/GSK-3β Pathway in Adult Rat Prefrontal Cortex

(2011) Dong Xi et al.   NEUROPSYCHOPHARMACOLOGY

Negative Symptoms and Social Cognition: Identifying Targets for Psychological Interventions

(2011) T. M. Lincoln et al.   SCHIZOPHRENIA BULLETIN

Cognitive neuroscience of self-regulation failure

(2011) Todd F. Heatherton et al.   TRENDS IN COGNITIVE SCIENCES

What does the amygdala contribute to social cognition?

(2010) Ralph Adolphs   Annals of the New York Academy of Sciences

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Long-Chain ω-3 Fatty Acids for Indicated Prevention of Psychotic Disorders

(2010) G. Paul Amminger et al.   ARCHIVES OF GENERAL PSYCHIATRY

Disruption of Performance in the Five-Choice Serial Reaction Time Task Induced By Administration of N-Methyl-D-Aspartate Receptor Antagonists: Relevance to Cognitive Dysfunction in Schizophrenia

(2010) Nurith Amitai et al.   BIOLOGICAL PSYCHIATRY

Neonatal exposure to MK-801, an N-methyl-d-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats

(2010) Takashi Uehara et al.   BRAIN RESEARCH

The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801

(2010) Karel Vales et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

(2010) Holger Rosenbrock et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabotropic glutamate receptor subtype 5 antagonism in learning and memory

(2010) Agnes Simonyi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade

(2010) Mark R. Stefani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats

(2010) S.W. Fowler et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Mechanism-based approaches to treating fragile X

(2010) Gül Dölen et al.   PHARMACOLOGY & THERAPEUTICS

MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?

(2010) Joshua D. Vardigan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Homer1a-Dependent Crosstalk Between NMDA and Metabotropic Glutamate Receptors in Mouse Neurons

(2010) Federica Bertaso et al.   PLoS One

Risperidone Administered During Asymptomatic Period of Adolescence Prevents the Emergence of Brain Structural Pathology and Behavioral Abnormalities in an Animal Model of Schizophrenia

(2010) Y. Piontkewitz et al.   SCHIZOPHRENIA BULLETIN

Early postnatal depletion of NMDA receptor development affects behaviour and NMDA receptor expression until later adulthood in rats—A possible model for schizophrenia

(2009) Paul Christian Baier et al.   BEHAVIOURAL BRAIN RESEARCH

Neonatal Phencyclidine Treatment in Mice Induces Behavioral, Histological and Neurochemical Abnormalities in Adulthood

(2009) Akiko Nakatani-Pawlak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Clozapine Administration in Adolescence Prevents Postpubertal Emergence of Brain Structural Pathology in an Animal Model of Schizophrenia

(2009) Yael Piontkewitz et al.   BIOLOGICAL PSYCHIATRY

U-Shaped Dose Response in Behavioral Pharmacology: Historical Foundations

(2009) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade

(2009) Teresa Marie du Bois et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A Double-Blind, Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Early-Phase Schizophrenia

(2009) Yechiel Levkovitz et al.   JOURNAL OF CLINICAL PSYCHIATRY

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

(2009) Jason M. Uslaner et al.   NEUROPHARMACOLOGY

mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

(2009) Jennifer E Ayala et al.   NEUROPSYCHOPHARMACOLOGY

Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells

(2009) Kittikun Viwatpinyo et al.   NEUROSCIENCE LETTERS

Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia

(2009) Chantal Schlumberger et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis

(2009) Urs Meyer et al.   PSYCHOPHARMACOLOGY

MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats

(2008) Gert R.J. Christoffersen et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats

(2008) Thomas Secher et al.   BEHAVIOURAL BRAIN RESEARCH

Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm

(2008) Justin M. Darrah et al.   BEHAVIOURAL PHARMACOLOGY

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro

(2008) Sergey Neyman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

ADX47273 [S-(4-Fluoro-phenyl)- -methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

(2008) F. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆

(2008) D BOULAY et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice

(2008) Ming-Huan Chan et al.   PSYCHOPHARMACOLOGY

Metabotropic Glutamate Receptors and Fragile X Mental Retardation Protein: Partners in Translational Regulation at the Synapse

(2008) J. A. Ronesi et al.   Science Signaling