Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Single-molecule imaging revealed dynamic GPCR dimerization

(2013) Rinshi S Kasai et al.   CURRENT OPINION IN CELL BIOLOGY

Structural mechanism of ligand activation in human GABAB receptor

(2013) Yong Geng et al.   NATURE

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

(2013) E. Doumazane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhodopsin Forms a Dimer with Cytoplasmic Helix 8 Contacts in Native Membranes

(2012) Adam M. Knepp et al.   BIOCHEMISTRY

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

(2012) José L. Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers

(2012) Xavier Periole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

(2012) D. El Moustaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

(2012) D. Calebiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1

(2012) V. Hlavackova et al.   Science Signaling

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

The oligomeric state sets GABABreceptor signalling efficacy

(2011) Laëtitia Comps-Agrar et al.   EMBO JOURNAL

Independent HHsearch, Needleman-Wunsch-Based, and Motif Analyses Reveal the Overall Hierarchy for Most of the G Protein-Coupled Receptor Families

(2011) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Interdomain movements in metabotropic glutamate receptor activation

(2011) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

(2010) Carine Monnier et al.   EMBO JOURNAL

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

(2010) Philippe Rondard et al.   NEUROPHARMACOLOGY

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Class A GPCR heterodimers: evidence from binding studies

(2010) Nigel J.M. Birdsall   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional crosstalk between GPCRs: with or without oligomerization

(2009) Laurent Prezeau et al.   CURRENT OPINION IN PHARMACOLOGY

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor

(2008) Filippo Mancia et al.   EMBO REPORTS

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY