Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease

(2018) Yi-Ying Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting metabotropic glutamate receptors for the treatment of neuroinflammation

(2018) Francesco Fazio et al.   CURRENT OPINION IN PHARMACOLOGY

Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease

(2018) Filippo Caraci et al.   CURRENT OPINION IN PHARMACOLOGY

Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice

(2018) J. Vérité et al.   Journal of Neuroinflammation

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

(2018) Dunja Knezevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection

(2018) Danuta Jantas et al.   NEUROPHARMACOLOGY

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

(2018) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Neuron–Glia Crosstalk and Neuropathic Pain: Involvement in the Modulation of Motor Activity in the Orofacial Region

(2017) Mohammad Hossain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nociception modulation by supraspinal group III metabotropic glutamate receptors

(2017) Enza Palazzo et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9

(2017) Simona Federica Spampinato et al.   JOURNAL OF NEUROCHEMISTRY

Biology of GDNF and its receptors — Relevance for disorders of the central nervous system

(2017) Carlos F. Ibáñez et al.   NEUROBIOLOGY OF DISEASE

Metabotropic Glutamate Receptors Protect Oligodendrocytes from Acute Ischemia in the Mouse Optic Nerve

(2017) Arthur M. Butt et al.   NEUROCHEMICAL RESEARCH

Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors

(2017) Daniela Durand et al.   NEUROPHARMACOLOGY

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A “dark side” in the development of new symptomatic treatments for neurologic and psychiatric disorders

(2017) Valeria Bruno et al.   NEUROPHARMACOLOGY

Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway

(2017) Xinchun Ye et al.   NEUROSCIENCE LETTERS

Metabotropic glutamate receptors and neurodegenerative diseases

(2017) Fabiola M. Ribeiro et al.   PHARMACOLOGICAL RESEARCH

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

(2017) Federica Mastroiacovo et al.   Molecular Brain

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

(2017) Martina Beneventano et al.   Frontiers in Pharmacology

Disease-Induced Neuroinflammation and Depression

(2016) Cristina Benatti et al.   CNS & Neurological Disorders-Drug Targets

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia

(2016) Ranjani Ponnazhagan et al.   Journal of Neuroimmune Pharmacology

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities

(2016) Richard Macrez et al.   LANCET NEUROLOGY

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease

(2016) François Tison et al.   MOVEMENT DISORDERS

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

(2015) Benjamin Ettle et al.   MOLECULAR NEUROBIOLOGY

Conformational dynamics of a class C G-protein-coupled receptor

(2015) Reza Vafabakhsh et al.   NATURE

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

(2015) Giuseppe Battaglia et al.   NEUROBIOLOGY OF DISEASE

Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism

(2015) Hannah A. Hathaway et al.   NEUROPHARMACOLOGY

Activation of Type 4 Metabotropic Glutamate Receptor Attenuates Oxidative Stress-Induced Death of Neural Stem Cells with Inhibition of JNK and p38 MAPK Signaling

(2015) Zhichao Zhang et al.   STEM CELLS AND DEVELOPMENT

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes

(2015) Simona Federica Spampinato et al.   Frontiers in Cellular Neuroscience

A key role for TGF-β1 in hippocampal synaptic plasticity and memory

(2015) Filippo Caraci et al.   Scientific Reports

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

(2015) F. Guida et al.   Molecular Brain

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

(2015) Marta Motolese et al.   Molecular Brain

Protection of TGF-β1 against Neuroinflammation and Neurodegeneration in Aβ1–42-Induced Alzheimer’s Disease Model Rats

(2015) Jia-Hui Chen et al.   PLoS One

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation

(2014) Fengtian Xue et al.   CNS & Neurological Disorders-Drug Targets

Metabotropic Glutamate Receptor 5 in Down's Syndrome Hippocampus During Development: Increased Expression in Astrocytes

(2014) A.M. Iyer et al.   Current Alzheimer Research

Human CNS immune senescence and neurodegeneration

(2014) Wolfgang J Streit et al.   CURRENT OPINION IN IMMUNOLOGY

White matter injury: Ischemic and nonischemic

(2014) Robert F. Fern et al.   GLIA

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

(2014) S. Yin et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice

(2014) Francesco Fazio et al.   NEUROPHARMACOLOGY

Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell

(2014) F. Liu et al.   NEUROSCIENCE

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(2014) David J. Loane et al.   Neurotherapeutics

From development to dysfunction: Microglia and the complement cascade in CNS homeostasis

(2013) Matthew K. Zabel et al.   AGEING RESEARCH REVIEWS

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins

(2013) L. Iacovelli et al.   NEUROPHARMACOLOGY

Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

(2013) Daniela Durand et al.   NEUROPHARMACOLOGY

Grey matter damage in multiple sclerosis

(2013) Roel Klaver et al.   Prion

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

(2013) Maryse Paquet et al.   Molecular Brain

Extracellular membrane microvesicles and nanotubes in the brain: understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential

(2013) Claudia Verderio   Frontiers in Physiology

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release

(2012) Stephen M McMullan et al.   ASN Neuro

Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats

(2012) Jia-Wei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

(2012) Matthew J Betts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual Effect of 17β-Estradiol on NMDA-Induced Neuronal Death: Involvement of Metabotropic Glutamate Receptor 1

(2012) Simona Federica Spampinato et al.   ENDOCRINOLOGY

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes

(2012) Ankit Shah et al.   Journal of Neuroinflammation

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms

(2012) Juan E. Tichauer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Role of Glia in Alpha-Synucleinopathies

(2012) Lisa Fellner et al.   MOLECULAR NEUROBIOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

mGlu3 receptor and astrocytes: Partners in neuroprotection

(2012) Daniela Durand et al.   NEUROPHARMACOLOGY

Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

(2012) J.V. Berger et al.   NEUROSCIENCE

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus

(2012) Pengbo Yang et al.   Neuroscience Bulletin

Defining protein kinase/phosphatase isoenzymic regulation of mGlu5receptor-stimulated phospholipase C and Ca2+responses in astrocytes

(2011) SJ Bradley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dysfunction of TGF-β1 signaling in Alzheimer’s disease: perspectives for neuroprotection

(2011) Filippo Caraci et al.   CELL AND TISSUE RESEARCH

TRPV1-Dependent and -Independent Alterations in the Limbic Cortex of Neuropathic Mice: Impact on Glial Caspases and Pain Perception

(2011) Catia Giordano et al.   CEREBRAL CORTEX

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death

(2011) Simona D'Antoni et al.   NEUROBIOLOGY OF DISEASE

Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells

(2011) Anthony C. Vernon et al.   NEUROCHEMISTRY INTERNATIONAL

Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia

(2011) Lauren L. Jantzie et al.   Neuron Glia Biology

Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection

(2011) Thomas M. Piers et al.   NEUROSCIENCE LETTERS

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Differential distribution of group I metabotropic glutamate receptors in developing human cortex

(2010) Karin Boer et al.   BRAIN RESEARCH

Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition

(2010) Houman Homayoun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

(2010) Janelle Drouin-Ouellet et al.   GLIA

Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum

(2010) Yamina Bakiri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies  -Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

(2010) F. Caraci et al.   MOLECULAR PHARMACOLOGY

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

(2010) Francesca Fallarino et al.   NATURE MEDICINE

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

(2009) Christopher S. Casley et al.   BRAIN RESEARCH

Neuroglia in neurodegeneration

(2009) Michael T. Heneka et al.   BRAIN RESEARCH REVIEWS

Glutamate induces directed chemotaxis of microglia

(2009) Guo Jun Liu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia

(2009) Nicola Hamilton et al.   GLIA

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes

(2009) Daniela Durand et al.   JOURNAL OF NEUROCHEMISTRY

Multiple functions of the paranodal junction of myelinated nerve fibers

(2009) Jack Rosenbluth   JOURNAL OF NEUROSCIENCE RESEARCH

Evidence Group I mGluR Drugs Modulate the Activation Profile of Lipopolysaccharide-Exposed Microglia in Culture

(2009) Mark C. Farso et al.   NEUROCHEMICAL RESEARCH

Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons

(2009) Giuseppe Battaglia et al.   PLoS One

Sorting Out Astrocyte Physiology from Pharmacology

(2008) Todd A. Fiacco et al.   Annual Review of Pharmacology and Toxicology

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells

(2008) Noritaka Nakamichi et al.   JOURNAL OF NEUROCHEMISTRY

Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors

(2008) Fleur Pinteaux-Jones et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY