Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2

Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site

(2014) Karen J. Gregory et al.   ACS Chemical Neuroscience

QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators

(2014) Gary Tresadern et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

mGluR2 positive allosteric modulators: a patent review (2009 – present)

(2013) Andrés A Trabanco et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

(2012) Jose María Cid et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

(2012) Andrés A. Trabanco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

(2012) Jose María Cid et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

(2011) L Lundström et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabotropic glutamate receptors and the control of chronic pain

(2011) Santina Chiechio et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting of Metabotropic Glutamate Receptors for the Treatment of Schizophrenia

(2011) Shigeyuki Chaki et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Metabotropic glutamate receptors as therapeutic targets for schizophrenia

(2011) Paige N. Vinson et al.   NEUROPHARMACOLOGY

Interdomain movements in metabotropic glutamate receptor activation

(2011) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

(2010) Jose María Cid et al.   ACS Chemical Neuroscience

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

(2010) Andrés A. Trabanco et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

(2010) A. A. Trabanco et al.   CURRENT MEDICINAL CHEMISTRY

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neurochemical Changes

(2010) M. J. Fell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

(2010) Andrés A. Trabanco et al.   MedChemComm

Differential Expression of Metabotropic Glutamate Receptors 2 and 3 in Schizophrenia: A Mechanism for Antipsychotic Drug Action?

(2009) Subroto Ghose et al.   AMERICAN JOURNAL OF PSYCHIATRY

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

(2009) Gary Tresadern et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Dynamics Simulation of the Heterodimeric mGluR2/5HT2AComplex. An Atomistic Resolution Study of a Potential New Target in Psychiatric Conditions

(2009) Agostino Bruno et al.   Journal of Chemical Information and Modeling

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

(2008) Guibao Gu et al.   BRAIN RESEARCH

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

(2008) B. A. Rowe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS