Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

(2010) Thomas J. Woltering et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist3H-HYDIA

(2009) Linda Lundström et al.   ChemMedChem

Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

(2009) Mark E Fraley   EXPERT OPINION ON THERAPEUTIC PATENTS

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

(2008) Thomas J. Woltering et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

(2008) Thomas J. Woltering et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

(2008) B. A. Rowe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Improved model building and assessment of the Calcium-sensing receptor transmembrane domain

(2007) Lintao Bu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS