Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Gastroenterology & Hepatology
Chamara Basnayake, Annelies Geeraerts, Ans Pauwels, Ger Koek, Michael Vaezi, Tim Vanuytsel, Jan Tack
Summary: The prevalence of duodenogastroesophageal reflux (DGER) increases with more advanced esophageal lesions in patients with gastroesophageal reflux disease (GERD) and persists in patients on proton pump inhibitor (PPI) therapy. PPIs appear to be effective in treating DGER, but further research is needed for future therapies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Article
Gastroenterology & Hepatology
Ans Pauwels, Karlien Raymenants, Annelies Geeraerts, Veerle Boecxstaens, Imke Masuy, Charlotte Broers, Tim Vanuytsel, Jan Tack
Summary: Baclofen has shown efficacy in reducing reflux parameters in patients with PPI refractory GERD symptoms, but only SAP+ patients experience clinical benefit after 4 weeks of treatment. pH-impedance monitoring is necessary before treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Anna Plocek, Beata Gebora-Kowalska, Wojciech Fendler, Ewa Toporowska-Kowalska
Summary: Diagnosis of gastro-oesophageal reflux disease in children with chronic neurological impairment remains a clinical challenge. This study validated reference values for assessing GOR in these children and determined the optimal cut-off level of the pH-impedance parameter for predicting endoscopic outcomes. Endoscopic findings showed that even with a low number of GOR episodes recorded by pH-impedance, children with chronic NI may still have endoscopic lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Luis R. Valdovinos, Michael D. Crowell, Reginald Bell, Marcelo F. Vela, C. Prakash Gyawali
Summary: The reduction of reflux episodes to physiological levels on pH-impedance monitoring is associated with improved outcomes in patients with regurgitation-predominant GERD. Treatment with magnetic sphincter augmentation significantly improved symptom and satisfaction scores, while also reducing acid exposure time and reflux episodes. Improvement in regurgitation score remained independently predictive of satisfaction with therapy, and a reduction to <40 reflux episodes was significantly associated with symptom response.
Review
Agriculture, Dairy & Animal Science
Anna Carolina Fernandez Alasia, Olivier Levionnois, Mathieu Raillard
Summary: Regurgitation and gastro-oesophageal reflux (GOR) are common complications in dogs under anaesthesia. Studies on these complications showed inconsistencies in definitions and assessment methods, making meaningful comparisons difficult. Standardization and re-evaluation of methods may be necessary to address these discrepancies.
Article
Gastroenterology & Hepatology
Kentaro Sugano, Stuart Jon Spechler, Emad M. El-Omar, Kenneth E. L. McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C. Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan, Robert Odze, Richard Peek, Massimo Rugge, Prateek Sharma, Jose D. Sollano, Michael Vieth, Justin Wu, Ming-Shiang Wu, Duowu Zou, Michio Kaminishi, Peter Malfertheiner
Summary: This study aims to achieve international consensus on the new definitions of Barrett's esophagus, gastro-esophageal junction, and gastro-esophageal junctional zone, which will provide support for future research addressing many issues concerning this important anatomical area and hopefully lead to improved classification and management of diseases related to the gastro-esophageal junction.
Article
Respiratory System
Sufyan Shakir, Carlos Echevarria, Simon Doe, Malcolm Brodlie, Christopher Ward, Stephen J. Bourke
Summary: Upper gastrointestinal and upper airway diseases are common in cystic fibrosis (CF) and may contribute to lower airway infection and inflammation. A longitudinal cohort study showed that treatment with CFTR modulators can improve respiratory reflux symptoms and sinonasal symptoms, as well as improve lung function and weight in patients with advanced CF.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Agriculture, Dairy & Animal Science
Paraskevi Tsompanidou, Joris H. Robben, Ioannis Savvas, Tilemahos Anagnostou, Nikitas N. Prassinos, George M. Kazakos
Summary: This study compares the effects of three different pre-anaesthetic fasting regimens on the incidence of gastro-oesophageal reflux (GOR) in dogs under anaesthesia. The results suggest that feeding the dogs 3 hours before anaesthesia does not reduce the GOR incidence compared to feeding them 12 hours before anaesthesia. However, the 3-hour fasting resulted in a lower oesophageal pH.
Article
Surgery
Anagi C. Wickremasinghe, Yazmin Johari, Helen Yue, Cheryl Laurie, Kalai Shaw, Julie Playfair, Paul Beech, Geoffrey Hebbard, Kenneth S. Yap, Wendy Brown, Paul Burton
Summary: Significant changes in gastro-intestinal function, food tolerance, and symptoms occur after sleeve gastrectomy (SG), which are correlated with alterations in oesophageal transit and gastric emptying.
Article
Cardiac & Cardiovascular Systems
Deepika Razia, Sumeet K. Mittal, Sarah Fournier, Rajat Walia, Michael A. Smith, Ross M. Bremner, Jasmine L. Huang
Summary: Gastro-oesophageal reflux disease after lung transplantation may contribute to chronic lung allograft dysfunction. Antireflux surgery can improve long-term allograft function and show a survival benefit. This study compares outcomes between medical and surgical management of reflux in lung recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Allergy
Bronwyn K. Brew, Catarina Almqvist, Cecilia Lundholm, Anna Andreasson, Kelli Lehto, Nicholas J. Talley, Tong Gong
Summary: GERD is a common comorbidity in adults with asthma, hay fever, and/or eczema. There is evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Oncology
Lyn Ley Lam, Nick Pavlakis, Kohei Shitara, Katrin M. Sjoquist, Andrew J. Martin, Sonia Yip, Yoon-Koo Kang, Yung-Jue Bang, Li-Tzong Chen, Markus Moehler, Tanios Bekaii-Saab, Thierry Alcindor, Christopher J. O'Callaghan, Niall C. Tebbutt, Wendy Hague, Howard Chan, Sun Young Rha, Keun-Wook Lee, Val Gebski, Anthony Jaworski, John Zalcberg, Timothy Price, John Simes, David Goldstein
Summary: This study aims to evaluate the efficacy and safety of regorafenib alone and in combination with nivolumab in advanced gastro-oesophageal cancer patients. The study consists of two international randomized controlled trials, comparing the efficacy of regorafenib versus placebo, and the efficacy of regorafenib plus nivolumab versus chemotherapy. The primary endpoint of the study is overall survival.
Review
Surgery
Rachel Xue Ning Lee, Nayer Rizkallah, Sonja Chiappetta, Christine Stier, Sjaak Pouwels, Nasser Sakran, Rishi Singhal, Kamal Mahawar, Brijesh Madhok
Summary: Revisional surgery after OAGB for GORD is rare, and the conversion to Roux-en-Y configuration is the most common choice when required.
Letter
Gastroenterology & Hepatology
Lukas Michaja Balsiger, Karen Van den Houte, Tenghao Zheng, Joran Toth, Linde Besard, Andre Franke, Mauro D'Amato, Jan Tack, Florencia Carbone
Letter
Gastroenterology & Hepatology
Jan Tack, Karen Van den Houte, Florencia Carbone
Article
Gastroenterology & Hepatology
Morgane Sallette, Jamila Lenz, Francois Mion, Sabine Roman
Summary: This study compared the frequency of motility disorders diagnosed with CCv3.0 and CCv4.0 and evaluated the severity of symptoms. The results showed that while the diagnoses remained mainly unchanged with both versions, CCv4.0 had a lower frequency of ineffective esophageal motility (IEM) compared to CCv3.0.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
I-Hsuan Huang, Jolien Schol, Florencia Carbone, Yaozhu J. Chen, Karen Van den Houte, Lukas Michaja Balsiger, Bert Broeders, Tim Vanuytsel, Jan Tack
Summary: This study investigated the symptom patterns in distinguishing gastroparesis from functional dyspepsia. The results showed that patients with gastroparesis-like symptoms had a higher prevalence of delayed gastric emptying and higher symptom severity compared to patients with FD symptoms.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Chris Varghese, Gabriel Schamberg, Stefan Calder, Stephen Waite, Daniel Carson, Daphne Foong, William Jiaen Wang, Vincent Ho, Jonathan Woodhead, Charlotte Daker, William Xu, Peng Du, Thomas L. Abell, Henry P. Parkman, Jan Tack, Christopher N. Andrews, Gregory O'Grady, Armen A. Gharibans
Summary: This study aimed to define normative reference intervals for BSGM spectral metrics in healthy controls. The results showed the median and reference intervals for BSGM metrics, including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index, BMI-adjusted amplitude, and fed:fasted amplitude ratio. This study provides reference values for diagnostic interpretations of abnormal gastric function using BSGM spectral data.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Nick Goelen, Mike Jones, I-Hsuan Huang, Florenca Carbone, Pieter Janssen, Jan Tack
Summary: Gastroparesis and functional dyspepsia are disorders characterized by upper gastrointestinal symptoms and multifaceted etiologies. The association between symptom improvement and acceleration of gastric emptying (GE) by prokinetic agents is not clear. This meta-analysis aimed to provide a transparent update on the association between symptom improvement and GE acceleration in patients with gastroparesis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Esther Colomier, Joost P. Algera, Karen Van den Houte, Magnus Simren, Jan Tack
Summary: A subgroup of patients with a disorder of gut-brain interaction (DGBI) experience various symptoms after eating, such as abdominal pain, gas-related symptoms, dyspeptic symptoms, and loose stool or urgency. Previous studies have examined the effects of dietary therapies, such as fiber-rich or restrictive diets, on patients with irritable bowel syndrome and other related disorders, but there is limited research on the underlying mechanisms of food-related symptoms. This review focuses on these potential mechanisms, including nutrient sensing and tasting, physical considerations, malabsorption, allergy-like reactions, and their interaction with the gut microbiota.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Lukas Michaja Balsiger, Florencia Carbone, Karlien Raymenants, Emidio Scarpellini, Jan Tack
Summary: Disorders of gut-brain interaction (DGBI) are common in clinical practice, and there are established recommendations for diagnosis and management. Patients with multiple DGBI diagnoses have more severe symptoms and impact, and the management approach for overlapping diagnoses is not well established. This Review aims to guide clinicians in understanding and managing overlapping DGBI through identifying causes, pitfalls, and practical approaches to diagnosis, treatment, and follow-up.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Emidio Scarpellini, Jan Tack
Summary: Background: Since the end of 2019, SARS-CoV-2 has caused the COVID-19 pandemic, and gastrointestinal (GI) symptoms during and after COVID-19 are receiving increasing attention. Methods: We review and comment on the prevalence, pathophysiology, and potential treatment options for GI disturbances in COVID-19. Results: Numerous reports show that a significant portion of COVID-19 patients experience GI symptoms both during and after the disease, with some experiencing symptoms for several months, even after vaccination. There is an ongoing debate regarding the association between GI symptoms and the outcome of COVID-19 patients. However, it is widely recognized that patients with chronic liver disease have a worse outcome. The similarities between GI symptoms and postinfectious functional dyspepsia and irritable bowel syndrome suggest that the gut microbiota may play a role. Preliminary reports and clinical trials have shown that modulating the gut microbiota could be an effective approach for treating and preventing COVID-19. Conclusion: GI symptoms have a significant impact on the natural course of both long-COVID-19 and non-long-COVID-19. Modulating the gut microbiota appears to be a promising target for disease treatment and prevention.
REVIEWS ON RECENT CLINICAL TRIALS
(2023)
Article
Gastroenterology & Hepatology
Johann P. Hreinsson, Hans Tornblom, Jan Tack, Douglas A. Drossman, William E. Whitehead, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Magnus Simren
Summary: This study evaluated the validity of the Rome IV criteria for gut-brain interaction disorders through factor analysis in global, geographical, gender, and age-group dimensions. The results indicate that the Rome IV criteria are globally valid and represent universal diagnostic entities for these disorders.
Article
Gastroenterology & Hepatology
Caroline M. G. Saleh, Pietro Familiari, Barbara A. J. Bastiaansen, Paul Fockens, Jan Tack, Guy Boeckxstaens, Raf Bisschops, Aaltje Lei, Marlies P. Schijven, Jan Guido Costamagna, Albert J. Bredenoord
Summary: This study compares the efficacy of POEM and PD for patients with persistent or recurrent symptoms after LHM. The results show that POEM has a higher success rate than PD, with a higher incidence of reflux esophagitis in the POEM group.
Article
Gastroenterology & Hepatology
Navkiran Thind Tornkvist, Magnus Simren, Johann P. Hreinsson, Jan Tack, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Axel Josefsson, Hans Tornblom
Summary: This study aimed to define the prevalence and impact of disorders of gut-brain interaction (DGBI) in Sweden. The results showed that the prevalence of DGBI in Sweden is similar to global data, and patients often experience anxiety and/or depression, reduced quality of life, and frequent healthcare utilization. Prescription medication can provide relief for GI symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Serhat Bor, Xuicai Fang, Shrikant I. Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Murat Buyruk, Nalan Unal, Dan Huang, Jun Song, Johann P. Hreinsson, Olafur S. Palsson
Summary: The Rome Foundation Global Epidemiology Study (RFGES) assessed the prevalence, burden, and associated factors of Disorders of Gut-Brain Interaction (DGBI) in 33 countries. Two surveying methods (household interviews and Internet surveys) were used, and the findings showed that DGBI were only half as prevalent when assessed with household surveys compared to Internet surveys. The choice of survey method significantly affects symptom reporting and DGBI prevalence outcomes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Pharmacology & Pharmacy
Tom de Waal, Joachim Brouwers, Philippe Berben, Talia Flanagan, Jan Tack, Wim Vandenberghe, Tim Vanuytsel, Patrick Augustijns
Summary: Parkinson's disease may not only impact the motor system but also the physiology of the gastrointestinal tract. The composition of intestinal fluids in PD patients is generally similar to healthy controls, with only minor differences. These differences may be attributed to slower gastric emptying and altered intestinal bacterial metabolism.
Editorial Material
Gastroenterology & Hepatology
Michael Camilleri, Jan Tack