Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

Association of Single-Nucleotide Polymorphisms in a Metabotropic Glutamate Receptor GRM3 Gene Subunit to Alcohol-Dependent Male Subjects

(2014) Yan Xia et al.   ALCOHOL AND ALCOHOLISM

mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T- and Y-maze cognitive tests

(2014) Mira Lainiola et al.   BEHAVIOURAL BRAIN RESEARCH

Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine

(2014) M.-A. Enoch et al.   GENES BRAIN AND BEHAVIOR

M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location

(2014) D. J. Foster et al.   JOURNAL OF NEUROSCIENCE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

(2014) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

(2014) Jerri M Rook et al.   NEUROPSYCHOPHARMACOLOGY

The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder

(2014) Niamh L. O’Brien et al.   PSYCHIATRIC GENETICS

Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes

(2014) Ryuta Fujioka et al.   Molecular Brain

A neurocognitive approach to understanding the neurobiology of addiction

(2013) Xavier Noël et al.   CURRENT OPINION IN NEUROBIOLOGY

Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative Allosteric Modulator (NAM)

(2013) Cody J. Wenthur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study

(2013) Sandeep Pendyam et al.   JOURNAL OF NEUROPHYSIOLOGY

Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder

(2013) Radhika Kandaswamy et al.   JAMA Psychiatry

Cortical circuit dysfunction and cognitive deficits in schizophrenia - implications for preemptive interventions

(2012) David A. Lewis   EUROPEAN JOURNAL OF NEUROSCIENCE

Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs

(2012) Francisco Sotres-Bayon et al.   NEURON

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala

(2012) Sarah J. Lucas et al.   NEUROPHARMACOLOGY

Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia

(2011) A. Jablensky et al.   GENES BRAIN AND BEHAVIOR

The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear

(2011) T. Amano et al.   JOURNAL OF NEUROSCIENCE

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Reduced expression of conditioned fear in the R6/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex

(2011) Adam G. Walker et al.   NEUROBIOLOGY OF DISEASE

Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata

(2011) Kari A. Johnson et al.   NEUROSCIENCE LETTERS

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors

(2011) J. Ster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural circuits underlying the pathophysiology of mood disorders

(2011) Joseph L. Price et al.   TRENDS IN COGNITIVE SCIENCES

Prefrontal control of fear: more than just extinction

(2010) Francisco Sotres-Bayon et al.   CURRENT OPINION IN NEUROBIOLOGY

Metabotropic glutamate2/3 (mGlu2/3) receptors, schizophrenia and cognition

(2010) Gerard J. Marek   EUROPEAN JOURNAL OF PHARMACOLOGY

Postsynaptic and Presynaptic Group II Metabotropic Glutamate Receptor Activation Reduces Neuronal Excitability in Rat Midline Paraventricular Thalamic Nucleus

(2010) M. L. H. J. Hermes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction

(2010) A.A. Wilber et al.   NEUROSCIENCE

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In Vivo Activity of Allosteric mGluR1 Antagonists

(2009) Gentaroh Suzuki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metabotropic Glutamate Receptor 2 and 3 Gene Expression in The Human Prefrontal Cortex and Mesencephalon in Schizophrenia

(2008) Subroto Ghose et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia

(2008) PJ Harrison et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex

(2008) Chiung-Chun Huang et al.   NEUROPHARMACOLOGY