Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

(2015) Emilie Macé et al.   MOLECULAR THERAPY

Retinal implants: a systematic review: Table 1

(2014) Alice T Chuang et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

(2014) T. Cronin et al.   EMBO Molecular Medicine

A Role for Melanopsin in Alpha Retinal Ganglion Cells and Contrast Detection

(2014) Tiffany M. Schmidt et al.   NEURON

miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function

(2014) Volker Busskamp et al.   NEURON

ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration

(2014) Zhuo-Hua Pan et al.   PLoS One

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells

(2013) Tianqing Li et al.   CELL RESEARCH

Optical control of metabotropic glutamate receptors

(2013) Joshua Levitz et al.   NATURE NEUROSCIENCE

Immunology of AAV-Mediated Gene Transfer in the Eye

(2013) Keirnan Willett et al.   Frontiers in Immunology

Melanopsin-Based Brightness Discrimination in Mice and Humans

(2012) Timothy M. Brown et al.   CURRENT BIOLOGY

Melanopsin Is Highly Resistant to Light and Chemical Bleachingin Vivo

(2012) Timothy J. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Active Site of Melanopsin: The Biological Clock Photoreceptor

(2012) Sivakumar Sekharan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemical Restoration of Visual Responses in Blind Mice

(2012) Aleksandra Polosukhina et al.   NEURON

Caspase-3-independent photoreceptor degeneration by N-methyl-N-nitrosourea (MNU) induces morphological and functional changes in the mouse retina

(2011) Rahel Zulliger et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

mGluR6 deletion renders the TRPM1 channel in retina inactive

(2011) Ying Xu et al.   JOURNAL OF NEUROPHYSIOLOGY

An Intrinsic Neural Oscillator in the Degenerating Mouse Retina

(2011) J. Borowska et al.   JOURNAL OF NEUROSCIENCE

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins

(2011) Sonja Kleinlogel et al.   NATURE METHODS

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Visual Function in Mice with Photoreceptor Degeneration and Transgenic Expression of Channelrhodopsin 2 in Ganglion Cells

(2010) S. Thyagarajan et al.   JOURNAL OF NEUROSCIENCE

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

(2010) Ji-jing Pang et al.   MOLECULAR THERAPY

Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina

(2010) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Melanopsin Contributions to Irradiance Coding in the Thalamo-Cortical Visual System

(2010) Timothy M. Brown et al.   PLOS BIOLOGY

Cooperative Phagocytes

(2009) Sandrine Joly et al.   AMERICAN JOURNAL OF PATHOLOGY

An Alternative Pathway Mediates the Mouse and Human Cone Visual Cycle

(2009) Jin-Shan Wang et al.   CURRENT BIOLOGY

Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11·Gβ5Complex and Accelerates Inactivation of the mGluR6-GoSignaling

(2009) Ikuo Masuho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cone Contacts, Mosaics, and Territories of Bipolar Cells in the Mouse Retina

(2009) H. Wassle et al.   JOURNAL OF NEUROSCIENCE

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

(2009) Francesca Simonelli et al.   MOLECULAR THERAPY

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Channelrhodopsin-2 is a leaky proton pump

(2009) K. Feldbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells

(2009) Catherine W. Morgans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptive field properties of ON- and OFF-ganglion cells in the mouse retina

(2009) MICHIEL VAN WYK et al.   VISUAL NEUROSCIENCE

Clinical gene therapy using recombinant adeno-associated virus vectors

(2008) C Mueller et al.   GENE THERAPY

Disinhibition Combines with Excitation to Extend the Operating Range of the OFF Visual Pathway in Daylight

(2008) M. B. Manookin et al.   JOURNAL OF NEUROSCIENCE

A Core Paired-Type and POU Homeodomain-Containing Transcription Factor Program Drives Retinal Bipolar Cell Gene Expression

(2008) D. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Signals and noise in an inhibitory interneuron diverge to control activity in nearby retinal ganglion cells

(2008) Gabe J Murphy et al.   NATURE NEUROSCIENCE

Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin

(2008) B. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA