Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer’s mouse model

(2020) Sitara B. Sankar et al.   Journal of Neuroinflammation

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2020) Yevgeniya A. Abramzon et al.   Frontiers in Neuroscience

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

(2020) Tomohiro Imamura et al.   NEUROBIOLOGY OF DISEASE

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

(2020) Osman Shabir et al.   Scientific Reports

Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer’s disease and type 2 diabetes

(2020) Carmen Hierro-Bujalance et al.   Alzheimers Research & Therapy

Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS

(2019) Sarah Y. Ebstein et al.   Cell Reports

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

(2019) Tomoko Wakabayashi et al.   Molecular Neurodegeneration

The Dentate Gyrus and Temporal Lobe Epilepsy: An “Exciting” Era

(2019) Helen E. Scharfman   Epilepsy Currents

Advanced Glycation End Products: Building on the Concept of the “Common Soil” in Metabolic Disease

(2019) Henry H Ruiz et al.   ENDOCRINOLOGY

A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice

(2019) Skye Hsin-Hsien Yeh et al.   NEUROBIOLOGY OF AGING

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease

(2019) Paul Denver et al.   Frontiers in Physiology

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

(2019) Dennis W. Dickson et al.   Acta Neuropathologica Communications

The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease

(2019) Bhumsoo Kim et al.   NEUROBIOLOGY OF DISEASE

A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy

(2018) A. Kodam et al.   BRAIN PATHOLOGY

Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models

(2018) Marina Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

(2018) Juliane K Czeczor et al.   JOURNAL OF ENDOCRINOLOGY

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

(2018) Matthew A. White et al.   NATURE NEUROSCIENCE

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

High-fat diet protects the blood-brain barrier in an Alzheimer's disease mouse model

(2018) Shirin Elhaik Goldman et al.   AGING CELL

Midlife Rheumatoid Arthritis Increases the Risk of Cognitive Impairment Two Decades Later: A Population-Based Study

(2018) Karin Wallin et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis

(2018) Osman Shabir et al.   BMC NEUROSCIENCE

Insulin Resistance in Alzheimer's Disease

(2018) Laís S. S. Ferreira et al.   Frontiers in Neuroscience

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Obesity pandemic: causes, consequences, and solutions—but do we have the will?

(2017) David R. Meldrum et al.   FERTILITY AND STERILITY

Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia

(2017) Alexander J. Beagle et al.   JOURNAL OF ALZHEIMERS DISEASE

Mouse Models of Alzheimer’s Disease

(2017) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Type 2 diabetes

(2017) Sudesna Chatterjee et al.   LANCET

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

(2017) Shuai Zhang et al.   Oncotarget

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

(2017) Syed F. Kazim et al.   Frontiers in Aging Neuroscience

Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

(2017) Ryusuke Takechi et al.   Frontiers in Aging Neuroscience

Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus

(2017) Jens Velde Andersen et al.   NEURAL PLASTICITY

Limited Alzheimer-Type Neurodegeneration in Experimental Obesity and Type 2 Diabetes Mellitus

(2017) Natalie Moroz et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Resistant Brain State after Intracerebroventricular Streptozotocin Injection Exacerbates Alzheimer-like Changes in Tg2576 AβPP-Overexpressing Mice

(2017) Konstanze Plaschke et al.   JOURNAL OF ALZHEIMERS DISEASE

Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis

(2017) Kay Deckers et al.   PLoS One

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice

(2016) Yan-Fang Mao et al.   AGING CELL

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Do theApoe−/−andLdlr−/–Mice Yield the Same Insight on Atherogenesis?Highlights: Table.

(2016) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Advanced glycation end products: An emerging biomarker for adverse outcome in patients with peripheral artery disease

(2016) Lisanne C. de Vos et al.   ATHEROSCLEROSIS

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Which insights have we gained from the kindling and post-status epilepticus models?

(2016) Jan A. Gorter et al.   JOURNAL OF NEUROSCIENCE METHODS

Animal models of post-traumatic epilepsy

(2016) Thomas Ostergard et al.   JOURNAL OF NEUROSCIENCE METHODS

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease

(2016) Juan Jose Ramos-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Management of psychiatric and neurological comorbidities in epilepsy

(2016) Andres M. Kanner   Nature Reviews Neurology

The Epidemiology of Global Epilepsy

(2016) Anuradha Singh et al.   NEUROLOGIC CLINICS

Seizures in dominantly inherited Alzheimer disease

(2016) Aline Zarea et al.   NEUROLOGY

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD

(2016) Yuanjing Liu et al.   NEURON

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

(2016) Jie Jiang et al.   NEURON

Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

(2016) T.L. Platt et al.   NEUROSCIENCE

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

(2016) Aaron Burberry et al.   Science Translational Medicine

Molecular Genetics of Neurodegenerative Dementias

(2016) Flora I. Hinz et al.   Cold Spring Harbor Perspectives in Biology

High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

(2016) Peter Thériault et al.   Oncotarget

Endovascular ischemic stroke models of adult rhesus monkeys: a comparison of two endovascular methods

(2016) Di Wu et al.   Scientific Reports

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice

(2016) Giuseppe Perruolo et al.   Scientific Reports

C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

(2015) Max Koppers et al.   ANNALS OF NEUROLOGY

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts

(2015) Wolfgang Löscher et al.   EPILEPSY & BEHAVIOR

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus

(2015) Juan José Ramos-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation

(2015) Y-F Chuang et al.   MOLECULAR PSYCHIATRY

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

(2015) Owen M. Peters et al.   NEURON

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD

(2015) Jacqueline G. O’Rourke et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective

(2015) Francesco Zaccardi et al.   POSTGRADUATE MEDICAL JOURNAL

Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease

(2015) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

(2015) J. Chew et al.   SCIENCE

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease

(2015) Shun-Yao Ko et al.   PLoS One

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice

(2014) Mark Fuller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999–2008

(2014) Dean Sherzai et al.   EPILEPSY & BEHAVIOR

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

(2014) Sarah Herdewyn et al.   Molecular Neurodegeneration

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

(2014) Elysse M. Knight et al.   NEUROBIOLOGY OF AGING

Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: Implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression

(2014) Shunsuke Koga et al.   NEUROBIOLOGY OF DISEASE

Central Proliferation and Neurogenesis Is Impaired in Type 2 Diabetes and Prediabetes Animal Models

(2014) Juan Jose Ramos-Rodriguez et al.   PLoS One

Establishment of an animal model of vascular dementia

(2014) HAO WANG   Experimental and Therapeutic Medicine

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

(2014) Dana M Niedowicz et al.   Acta Neuropathologica Communications

Mechanism linking diabetes mellitus and obesity

(2014) Abdullah Algoblan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway

(2013) Xu Wang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Hyperlipidemia Disrupts Cerebrovascular Reflexes and Worsens Ischemic Perfusion Defect

(2013) Cenk Ayata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

(2013) B. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

(2013) R. Potter et al.   Science Translational Medicine

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Pathology of Lacunar Ischemic Stroke in Humans-A Systematic Review

(2012) Emma L. Bailey et al.   BRAIN PATHOLOGY

Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease

(2012) Iddo Magen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Depression in epilepsy: A systematic review and meta-analysis

(2012) K. M. Fiest et al.   NEUROLOGY

Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies

(2012) Wei-Ting Chen et al.   PLoS One

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

(2012) Matthias Cacquevel et al.   PLoS One

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

(2012) Xiao-Xin Yan et al.   PLoS One

Myelin Loss Associated With Neuroinflammation in Hypertensive Rats

(2012) Fakhreya Y. Jalal et al.   STROKE

Interleukin‐1 Mediates Neuroinflammatory Changes Associated With Diet‐Induced Atherosclerosis

(2012) Adam Denes et al.   Journal of the American Heart Association

Central Obesity in the Elderly is Related to Late-onset Alzheimer Disease

(2011) José A. Luchsinger et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Psychiatric Disorders Presenting in the Elderly With Type 2 Diabetes Mellitus

(2011) Kannayiram Alagiakrishnan et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Alzheimer-type neuropathological changes in morbidly obese elderly individuals

(2011) R.E. Mrak   CLINICAL NEUROPATHOLOGY

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Is the Spontaneously Hypertensive Stroke Prone Rat a Pertinent Model of Sub Cortical Ischemic Stroke? A Systematic Review

(2011) Emma L. Bailey et al.   International Journal of Stroke

Estimating the Number of Persons with Frontotemporal Lobar Degeneration in the US Population

(2011) David S. Knopman et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Gastrointestinal Dysfunction in a Parkinson’s Disease Rat Model and the Changes of Dopaminergic, Nitric Oxidergic, and Cholinergic Neurotransmitters in Myenteric Plexus

(2011) Hong Can Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet

(2011) Guohua Song et al.   Lipids in Health and Disease

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus

(2011) P. Elyse Schauwecker   NEUROBIOLOGY OF DISEASE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

(2010) Jill K. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mouse models of the metabolic syndrome

(2010) A. J. Kennedy et al.   Disease Models & Mechanisms

Ldlr−/−Mice Display Decreased Susceptibility to Western-Type Diet-Induced Obesity Due to Increased Thermogenesis

(2010) Ying Fai Ngai et al.   ENDOCRINOLOGY

Increased Food Intake Leads to Obesity and Insulin Resistance in the Tg2576 Alzheimer’s Disease Mouse Model

(2010) Motoyuki Kohjima et al.   ENDOCRINOLOGY

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease

(2010) Angie A Kehagia et al.   LANCET NEUROLOGY

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy

(2010) Keiko Nishio et al.   STROKE

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Simple Rabbit Model of Vulnerable Atherosclerotic Plaque

(2009) Takashi SHIMIZU et al.   NEUROLOGIA MEDICO-CHIRURGICA

Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease

(2009) F. Blandini et al.   NEUROSCIENCE LETTERS

Loss of PDZK1 Causes Coronary Artery Occlusion and Myocardial Infarction in Paigen Diet-Fed Apolipoprotein E Deficient Mice

(2009) Ayce Yesilaltay et al.   PLoS One

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: A novel model of atherosclerosis associated with chronic inflammation

(2008) Raquel Largo et al.   ARTHRITIS AND RHEUMATISM

Increased locomotor activity in mice lacking the low-density lipoprotein receptor

(2008) Gregory A. Elder et al.   BEHAVIOURAL BRAIN RESEARCH

Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

(2008) Michael A Mastrangelo et al.   BMC NEUROSCIENCE

Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models

(2008) Miriam Marcela Blanco et al.   EPILEPSIA

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Neural control of the gastrointestinal tract: Implications for Parkinson disease

(2008) Maria G. Cersosimo et al.   MOVEMENT DISORDERS

Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease

(2008) M.T. Tadaiesky et al.   NEUROSCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE