Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

Soy Isoflavone Alleviates Aβ1-42-Induced Impairment of Learning and Memory Ability Through the Regulation of RAGE/LRP-1 in Neuronal and Vascular Tissue

(2013) Yuan-Di Xi et al.   CURRENT NEUROVASCULAR RESEARCH

Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition

(2013) C. Moran et al.   DIABETES CARE

Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62

(2013) Hyun-Jung Jung et al.   EXPERIMENTAL NEUROLOGY

Alzheimer's Disease: How Far Have We Progressed? Lessons Learned from Diabetes Mellitus, Metabolic Syndrome, and Inflammation

(2013) Giovanni Viscogliosi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease

(2013) Anna M. Barron et al.   PLoS One

Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study

(2013) Wenqing Xia et al.   PSYCHONEUROENDOCRINOLOGY

Contribution of Cerebrovascular Health to the Diagnosis of Alzheimer Disease

(2013) Karen M. Rodrigue   JAMA Neurology

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Association of Depression With Accelerated Cognitive Decline Among Patients With Type 2 Diabetes in the ACCORD-MIND Trial

(2013) Mark D. Sullivan et al.   JAMA Psychiatry

Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer’s disease

(2012) Sharlène Côté et al.   Alzheimers & Dementia

Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults

(2012) Linda K. McEvoy et al.   ANNALS OF EPIDEMIOLOGY

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

(2012) G. Cheng et al.   INTERNAL MEDICINE JOURNAL

Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

(2012) Wenzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

(2012) Caitriona M. Long-Smith et al.   NEUROMOLECULAR MEDICINE

Metformin for treatment of antipsychotic-induced weight gain: A randomized, placebo-controlled study

(2012) Man Wang et al.   SCHIZOPHRENIA RESEARCH

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer’s-like phenotypes in mice

(2011) Kazuma Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved diabetes control in the elderly delays global cognitive decline

(2011) José A. Luchsinger et al.   Journal of Nutrition Health & Aging

Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study

(2011) Jung-Lung Hsu et al.   NEUROIMAGE

Metabolic syndrome and cognitive decline in French elders: The Three-City Study

(2011) C. Raffaitin et al.   NEUROLOGY

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies

(2011) K. J. Anstey et al.   Obesity Reviews

Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors

(2010) Yael D. Reijmer et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

(2010) John Gunstad et al.   NEUROEPIDEMIOLOGY

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus

(2009) E. van den Berg et al.   DIABETOLOGIA

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Protective actions of sex steroid hormones in Alzheimer’s disease

(2009) Christian J. Pike et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Testosterone deficiency, insulin resistance and the metabolic syndrome

(2009) Michael Zitzmann   Nature Reviews Endocrinology

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease

(2009) Emily R. Rosario et al.   NEUROBIOLOGY OF AGING

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three definitions of metabolic syndrome applied to a sample of young obese men and their relation with plasma testosterone

(2008) N. P. Goncharov et al.   Aging Male

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

(2008) Jérome Terrand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

(2008) Mathis Grossmann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Diabetes Increases Atrophy and Vascular Lesions on Brain MRI in Patients With Symptomatic Arterial Disease

(2008) Audrey M. Tiehuis et al.   STROKE

Tfm-AR modulates the effects of ApoE4 on cognition

(2007) Angela Rizk-Jackson et al.   JOURNAL OF NEUROCHEMISTRY