Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models

Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome

(2018) Panagiotis Zis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour

(2018) Nitika Garg et al.   REVIEWS IN THE NEUROSCIENCES

The association between dementia and epilepsy: A systematic review and meta-analysis

(2017) Ann Subota et al.   EPILEPSIA

The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy

(2017) Taha Gholipour et al.   EPILEPSY & BEHAVIOR

Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia

(2017) Alexander J. Beagle et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of PINCH signaling in mesial temporal epilepsy

(2017) Charles Liu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer’s disease

(2017) Ugur Damar et al.   MEDICAL HYPOTHESES

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy

(2017) P. Tacik et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity

(2017) Panagiotis Zis et al.   NEUROSCIENCE LETTERS

Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks

(2017) Peter Verstraelen et al.   Frontiers in Cellular Neuroscience

Tau exacerbates excitotoxic brain damage in an animal model of stroke

(2017) Mian Bi et al.   Nature Communications

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Park2-Null/Tau Transgenic Mice Reveal a Functional Relationship between Parkin and Tau

(2017) Rosa Guerrero et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of Tau Phosphorylation in Mouse Brain during Excitotoxic Damage

(2017) Zhihou Liang et al.   JOURNAL OF ALZHEIMERS DISEASE

Epileptic Seizures in Alzheimer Disease

(2016) András Horváth et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections

(2016) Xin You Tai et al.   BRAIN

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences

(2016) Yat-Fung Shea et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series

(2016) Natalie S Ryan et al.   LANCET NEUROLOGY

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression

(2016) K Le Guennec et al.   MOLECULAR PSYCHIATRY

Seizures in dominantly inherited Alzheimer disease

(2016) Aline Zarea et al.   NEUROLOGY

Tau pathology-mediated presynaptic dysfunction

(2016) H. Moreno et al.   NEUROSCIENCE

Similarity of symptoms between transient epileptic amnesia and Lewy body disease

(2016) Katsuyuki Ukai et al.   Psychogeriatrics

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Similarity of symptoms between transient epileptic amnesia and Lewy body disease

(2016) Katsuyuki Ukai et al.   Psychogeriatrics

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

(2015) Sandy R. Shultz et al.   BRAIN

A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy

(2015) Konrad J. Werhahn et al.   EPILEPSIA

Homozygous nonsense mutation in SYNJ1 associated with intractable epilepsy and tau pathology

(2015) David A. Dyment et al.   NEUROBIOLOGY OF AGING

Tau reduction prevents disease in a mouse model of Dravet syndrome

(2014) Ania L. Gheyara et al.   ANNALS OF NEUROLOGY

Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999–2008

(2014) Dean Sherzai et al.   EPILEPSY & BEHAVIOR

Progressive myoclonus epilepsy in Down syndrome patients with dementia

(2014) Giuseppe d’Orsi et al.   JOURNAL OF NEUROLOGY

Epileptic Seizure as a Precipitating Factor of Vascular Progressive Supranuclear Palsy: A Case Report

(2014) Giuseppe Lanza et al.   Journal of Stroke & Cerebrovascular Diseases

Seizure resistance without parkinsonism in aged mice after tau reduction

(2014) Zhiyong Li et al.   NEUROBIOLOGY OF AGING

Neurodegenerative Disease Phenotypes in Carriers of MAPT p.A152T, A Risk Factor for Frontotemporal Dementia Spectrum Disorders and Alzheimer Disease

(2013) Suzee E. Lee et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Synthetic Aβ oligomers (Aβ1–42 globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers

(2013) David Hermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epileptic seizure presenting as dementia with Lewy bodies

(2013) In Seok Park et al.   GENERAL HOSPITAL PSYCHIATRY

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Hyperphosphorylated Tau is Implicated in Acquired Epilepsy and Neuropsychiatric Comorbidities

(2013) Ping Zheng et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

Familial Progressive Supranuclear Palsy: A Literature Review

(2013) Shinsuke Fujioka et al.   Neurodegenerative Diseases

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

(2013) M. Goedert et al.   Cold Spring Harbor Perspectives in Medicine

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Incidence of New-Onset Seizures in Mild to Moderate Alzheimer Disease

(2012) Michael C. Irizarry   ARCHIVES OF NEUROLOGY

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Common factors among Alzheimer’s disease, Parkinson’s disease, and epilepsy: Possible role of the noradrenergic nervous system

(2012) Patricia Szot   EPILEPSIA

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features

(2012) Eleanna Kara et al.   NEUROBIOLOGY OF AGING

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of functional GABAA receptors in the Alzheimer diseased brain

(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

(2012) Sheng Jin et al.   Alzheimers Research & Therapy

Clinicopathological correlations in corticobasal degeneration

(2011) Suzee E. Lee et al.   ANNALS OF NEUROLOGY

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7

(2011) G.G. Kovacs et al.   CLINICAL NEUROPATHOLOGY

Seizures and Epilepsy in Alzheimer's Disease

(2011) Daniel Friedman et al.   CNS Neuroscience & Therapeutics

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

(2011) Günter U Höglinger et al.   NATURE GENETICS

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation

(2011) Arianna Bellucci et al.   Neurodegenerative Diseases

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Expression of frontotemporal dementia with parkinsonism associated to chromosome 17 tau induces specific degeneration of the ventral dentate gyrus and depressive-like behavior in mice

(2011) M. Llorens-Martin et al.   NEUROSCIENCE

Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid

(2011) Volker Nimmrich et al.   REVIEWS IN THE NEUROSCIENCES

Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid

(2011) María-Salud García-Ayllón   Frontiers in Molecular Neuroscience

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Neuropathology of variants of progressive supranuclear palsy

(2010) Dennis W Dickson et al.   CURRENT OPINION IN NEUROLOGY

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease

(2010) Eduardo Cumbo et al.   EPILEPSY & BEHAVIOR

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Senile myoclonic epilepsy: Delineation of a common condition associated with Alzheimer's disease in Down syndrome

(2010) Roberto De Simone et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Neuronal protein trafficking associated with Alzheimer disease

(2010) Bor Luen Tang   Cell Adhesion & Migration

Seizures in Alzheimer Disease

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Foramen ovale electrodes in the preoperative evaluation of temporal lobe epilepsy in children

(2009) Daniel Nilsson et al.   EPILEPSIA

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

(2009) David R Williams et al.   LANCET NEUROLOGY

Familial aggregation of parkinsonism in progressive supranuclear palsy

(2009) L. D. Kaat et al.   NEUROLOGY

Alzheimer’s Disease and Neuronal Network Activity

(2009) Marc Gleichmann et al.   NEUROMOLECULAR MEDICINE

Epileptic Seizures in AD Patients

(2009) A. J. Larner   NEUROMOLECULAR MEDICINE

Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease

(2009) Sarah M. Rothman et al.   NEUROMOLECULAR MEDICINE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

The Legacy of Patient H.M. for Neuroscience

(2009) Larry R. Squire   NEURON

Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene

(2008) Rosa Guerrero et al.   ACTA NEUROPATHOLOGICA

Calcium sensitivity and cooperativity of permeabilized rat mesenteric lymphatics

(2008) Patrick J. Dougherty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome

(2008) Satish C. Rao et al.   EPILEPSY & BEHAVIOR

Early-Onset Familial Lewy Body Dementia With Extensive Tauopathy: A Clinical, Genetic, and Neuropathological Study

(2008) Jordi Clarimón et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Atypical early-onset Alzheimer's disease caused by the Iranian APP mutation

(2008) Suzanne Granhøj Lindquist et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE