Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies

Challenges Associated with Metal Chelation Therapy in Alzheimer's Disease

(2017) Muralidhar L. Hegde et al.   JOURNAL OF ALZHEIMERS DISEASE

NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide

(2017) Nanditha G. Nair et al.   JOURNAL OF ALZHEIMERS DISEASE

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation

(2011) Lujia Zhou et al.   EMBO Molecular Medicine

Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides

(2011) Jeppe T. Pedersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substantial Contribution of the Two Imidazole Rings of the His13−His14 Dyad to Cu(II) Binding in Amyloid-β(1−16) at Physiological pH and Its Significance

(2011) Byong-kyu Shin et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Copper Promotes the Trafficking of the Amyloid Precursor Protein

(2010) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain

(2010) Chun-Yan Wang et al.   PLoS One

Zinc ions promote Alzheimer A  aggregation via population shift of polymorphic states

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

Copper Enhances Amyloid-β Peptide Neurotoxicity and non β-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-β Peptide

(2009) Xueling Dai et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

(2008) Rita Joao Guerreiro et al.   NEUROBIOLOGY OF AGING

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY