APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes-induced encephalopathy

(2018) Brent D. Aulston et al.   EXPERIMENTAL NEUROLOGY

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

(2017) Simon T. Bond et al.   FASEB JOURNAL

Amyloid precursor protein in pancreatic islets

(2017) Joshua A Kulas et al.   JOURNAL OF ENDOCRINOLOGY

Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism

(2017) J. K. Czeczor et al.   JOURNAL OF NEUROENDOCRINOLOGY

Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain

(2017) Kendra L. Puig et al.   Scientific Reports

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

(2016) Poomy Pandey et al.   Oncotarget

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

(2016) Vidhi Gaur et al.   Cell Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

(2015) Matthew R. Blake et al.   NEUROBIOLOGY OF DISEASE

Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice

(2015) Feng-Shiun Shie et al.   PLoS One

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

(2014) Philipp Ebel et al.   BIOCHEMICAL JOURNAL

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

(2014) D. Lee Hamilton et al.   DIABETOLOGIA

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

(2014) Sean L. McGee et al.   FASEB JOURNAL

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons

(2014) M. Ishii et al.   JOURNAL OF NEUROSCIENCE

Role of insulin resistance in Alzheimer’s disease

(2014) Zhiyou Cai et al.   METABOLIC BRAIN DISEASE

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse

(2014) Emma Cahill et al.   Frontiers in Pharmacology

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice

(2012) Marjelo A. Mines et al.   CELLULAR SIGNALLING

Amyloid-  Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

(2012) Y. Zhang et al.   DIABETES

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

(2009) Z. V. Goodger et al.   JOURNAL OF CELL SCIENCE

Hepatic triacylglycerol accumulation and insulin resistance

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

(2008) BE Needham et al.   JOURNAL OF PATHOLOGY