Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

(2012) Carlos Cruchaga et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Dynamic Analysis of Amyloid  -Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal A  during Age-Related Plaque Formation

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Fractional synthesis and clearance rates for amyloid β

(2011) Steven D Edland et al.   NATURE MEDICINE

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

(2011) Randall J Bateman et al.   Alzheimers Research & Therapy

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Acute  -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-  Production to Alternative APP Fragments without Amyloid-  Rebound

(2010) J. J. Cook et al.   JOURNAL OF NEUROSCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

(2009) Timo Grimmer et al.   BIOLOGICAL PSYCHIATRY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Biochemical markers in persons with preclinical familial Alzheimer disease

(2008) J. M. Ringman et al.   NEUROLOGY