Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

Alzheimer's Disease and Down Syndrome Rodent Models Exhibit Audiogenic Seizures

(2017) Cara J. Westmark et al.   JOURNAL OF ALZHEIMERS DISEASE

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition

(2016) Disha Shah et al.   Alzheimers & Dementia

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease

(2016) Sofya Ziyatdinova et al.   Current Alzheimer Research

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer’s disease mouse model

(2016) V Frazzini et al.   Cell Death & Disease

APP Causes Hyperexcitability in Fragile X Mice

(2016) Cara J. Westmark et al.   Frontiers in Molecular Neuroscience

Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology

(2016) Korey Kam et al.   Scientific Reports

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

 -Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a  -Subunit-Like Fashion

(2015) S. Hessler et al.   JOURNAL OF NEUROSCIENCE

Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease

(2015) Alicia M. Hall et al.   JOURNAL OF NEUROSCIENCE

The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease

(2015) Anita Stargardt et al.   NEUROBIOLOGY OF AGING

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

(2015) Federico Scala et al.   NEUROBIOLOGY OF AGING

Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age

(2015) Áine M. Duffy et al.   NEUROBIOLOGY OF AGING

Seizures in Alzheimer’s disease

(2015) H.A. Born   NEUROSCIENCE

Enhancement of Neurogenesis and Memory by a Neurotrophic Peptide in Mild to Moderate Traumatic Brain Injury

(2015) Muhammad Omar Chohan et al.   NEUROSURGERY

The CA3 region of the hippocampus: how is it? What is it for? How does it do it?

(2015) Enrico Cherubini et al.   Frontiers in Cellular Neuroscience

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Early Onset of Hypersynchronous Network Activity and Expression of a Marker of Chronic Seizures in the Tg2576 Mouse Model of Alzheimer’s Disease

(2015) Charlotte Bezzina et al.   PLoS One

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

(2014) Chun-ling Dai et al.   JOURNAL OF NEURAL TRANSMISSION

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Tau-Mediated NMDA Receptor Impairment Underlies Dysfunction of a Selectively Vulnerable Network in a Mouse Model of Frontotemporal Dementia

(2014) Brian A. Warmus et al.   JOURNAL OF NEUROSCIENCE

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Increased Hippocampal Excitability in the 3xTgAD Mouse Model for Alzheimer's Disease In Vivo

(2014) Katherine E. Davis et al.   PLoS One

Episodic-like memory is sensitive to both Alzheimer's-like pathological accumulation and normal ageing processes in mice

(2013) Katherine E. Davis et al.   BEHAVIOURAL BRAIN RESEARCH

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms

(2013) Jeannie Chin et al.   EPILEPSY & BEHAVIOR

Pattern separation and pattern completion in Alzheimer's disease: Evidence of rapid forgetting in amnestic mild cognitive impairment

(2013) Brandon A. Ally et al.   HIPPOCAMPUS

Persistent Receptor Activity Underlies Group I mGluR-Mediated Cellular Plasticity in CA3 Neuron

(2013) S. R. Young et al.   JOURNAL OF NEUROSCIENCE

Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2013) B. F. Corbett et al.   JOURNAL OF NEUROSCIENCE

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders

(2012) C J Westmark   MOLECULAR PSYCHIATRY

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Untangling” Alzheimer's Disease and Epilepsy

(2012) Helen E. Scharfman   Epilepsy Currents

Seizures and Epilepsy in Alzheimer's Disease

(2011) Daniel Friedman et al.   CNS Neuroscience & Therapeutics

Transgenic Mice as a Model for Alzheimers Disease

(2011) Christina Unger Lithner et al.   Current Alzheimer Research

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Dual Regulation of Fragile X Mental Retardation Protein by Group I Metabotropic Glutamate Receptors Controls Translation-Dependent Epileptogenesis in the Hippocampus

(2011) W. Zhao et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

Pattern separation in the hippocampus

(2011) Michael A. Yassa et al.   TRENDS IN NEUROSCIENCES

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Different electrophysiological actions of 24- and 72-hour aggregated amyloid-beta oligomers on hippocampal field population spike in both anesthetized and awake rats

(2010) Gergely Orbán et al.   BRAIN RESEARCH

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Regulatory BC1 RNA and the Fragile X Mental Retardation Protein: Convergent Functionality in Brain

(2010) Jun Zhong et al.   PLoS One

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Seizures in Alzheimer Disease

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Linking Hippocampal Structure and Function to Memory Performance in an Aging Population

(2009) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

BC1 Regulation of Metabotropic Glutamate Receptor-Mediated Neuronal Excitability

(2009) J. Zhong et al.   JOURNAL OF NEUROSCIENCE

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE