Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

Antihypertensive agents do not prevent blood–brain barrier dysfunction and cognitive deficits in dietary-induced obese mice

(2017) J C L Mamo et al.   INTERNATIONAL JOURNAL OF OBESITY

Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular DysfunctionClinical Perspective

(2016) Ben M. Sörensen et al.   CIRCULATION

Long-Term Supplementation of Microencapsulated ursodeoxycholic Acid Prevents Hypertension in a Mouse Model of Insulin Resistance

(2016) H. Al-Salami et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice

(2016) Alexis M Stranahan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

(2016) Roy Chun-Laam Ng et al.   Molecular Neurodegeneration

Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

(2016) T.L. Platt et al.   NEUROSCIENCE

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome

(2016) Corey Giles et al.   PLoS One

Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus

(2016) Jacobus F. A. Jansen et al.   Scientific Reports

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

(2016) Hyun Jik Lee et al.   Scientific Reports

Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease

(2015) Menuka Pallebage-Gamarallage et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

(2015) Claudia A. Grillo et al.   DIABETES

A Key Role of Insulin Receptors in Memory: Figure 1

(2015) Fernanda G. De Felice et al.   DIABETES

The role of fatty acids in insulin resistance

(2015) Barry Sears et al.   Lipids in Health and Disease

Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease

(2015) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

RAPAMYCIN RESTORES CEREBRAL BLOOD FLOW AND BLOOD-BRAIN BARRIER INTEGRITY IN APOE4 CARRIERS

(2014) Ai-Ling Lin   Alzheimers & Dementia

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

(2014) Sergio T. Ferreira et al.   Alzheimers & Dementia

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

(2014) Erika Calvo-Ochoa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood–brain barrier function in wild-type mice

(2013) Ryusuke Takechi et al.   Journal of Neuroinflammation

Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding

(2012) Ryusuke Takechi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

PPARγ Agonist Pioglitazone Reverses Memory Impairment and Biochemical Changes in a Mouse Model of Type 2 Diabetes Mellitus

(2012) Li-Ying Jiang et al.   CNS Neuroscience & Therapeutics

The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown

(2012) A. Kam et al.   CURRENT MEDICINAL CHEMISTRY

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

(2012) A. D. McNeilly et al.   DIABETOLOGIA

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

(2012) R. Takechi et al.   Neurodegenerative Diseases

Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?

(2012) Takahiko Kawamura et al.   Journal of Diabetes Investigation

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

(2010) Alison D. McNeilly et al.   BEHAVIOURAL BRAIN RESEARCH

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

(2010) Scott E. Kanoski et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Tumour necrosis factor-α affects blood-brain barrier permeability and tight junction-associated occludin in acute liver failure

(2010) Sa Lv et al.   LIVER INTERNATIONAL

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-β

(2009) Ryusuke Takechi et al.   BRITISH JOURNAL OF NUTRITION

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability

(2009) C. L. Allen et al.   DIABETES OBESITY & METABOLISM

Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells

(2009) Servio H Ramirez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension

(2009) Linda T. Tran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Diabetes, Cognitive Function, and the Blood-Brain Barrier

(2008) J. Huber   CURRENT PHARMACEUTICAL DESIGN

Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

(2008) H. B. Stolp et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY