Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease

Intranasal insulin administration may be highly effective in improving cognitive function in mice with cognitive dysfunction by reversing brain insulin resistance

(2020) Hui Lv et al.   Cognitive Neurodynamics

Alzheimer’s Disorder: Epigenetic connection and associated risk factors

(2020) Vivek Kumar Sharma et al.   Current Neuropharmacology

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies

(2020) Jonathan Chang-Cheng Shieh et al.   MOLECULAR NEUROBIOLOGY

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

(2020) Christian Hölscher   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

(2020) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

(2020) Ji A Seo et al.   Nature Communications

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

(2020) Giacomo Tondo et al.   Alzheimers Research & Therapy

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease

(2020) Vivek Kumar Sharma et al.   CURRENT DRUG TARGETS

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

(2020) Diana C.P. Mejido et al.   NEUROPHARMACOLOGY

Type 2 Diabetes Mellitus Drugs for Alzheimer’s Disease: Current Evidence and Therapeutic Opportunities

(2020) Lei Meng et al.   TRENDS IN MOLECULAR MEDICINE

The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies

(2019) Rafaella Araujo Gonçalves et al.   Frontiers in Cellular Neuroscience

Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts

(2019) Galit Weinstein et al.   PLoS One

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

(2019) Mateusz Maciejczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel SGLT2 inhibitor, SU‐011, improves glycaemic control in rodents without the risk of hypoglycaemia and weight gain

(2019) Fei Huang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Deciphering the Role of WNT Signaling in Metabolic Syndrome–Linked Alzheimer’s Disease

(2019) Abuzer Ali et al.   MOLECULAR NEUROBIOLOGY

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

(2019) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review

(2019) Jun Li et al.   Frontiers in Pharmacology

Autophagy Modulation as a Treatment of Amyloid Diseases

(2019) Zoe Mputhia et al.   MOLECULES

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells

(2019) Shiqun Liu et al.   FASEB JOURNAL

GluT4: A central player in hippocampal memory and brain insulin resistance

(2019) Ewan C. McNay et al.   EXPERIMENTAL NEUROLOGY

The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ25-35-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway

(2019) Yueshan Sun et al.   PHARMACEUTICAL BIOLOGY

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

(2019) Lin Jia et al.   Molecular Brain

Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

(2018) Jit Poddar et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

(2018) Samuel Frere et al.   NEURON

Precision pharmacology for Alzheimer’s disease

(2018) Harald Hampel et al.   PHARMACOLOGICAL RESEARCH

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

(2018) Christian Benedict et al.   Frontiers in Neuroscience

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

(2018) Estella A. Newcombe et al.   Journal of Neuroinflammation

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

(2018) Eugenio Barone et al.   MOLECULAR NEUROBIOLOGY

Ketogenic Diets for Adult Neurological Disorders

(2018) Tanya J. W. McDonald et al.   Neurotherapeutics

Different Patterns of Glucose Hypometabolism Underlie Functional Decline in Frontotemporal Dementia and Alzheimer’s Disease: FDG-PET Study

(2018) Mina Fukai et al.   Neuropsychiatry

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

(2018) Andrea Tumminia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

(2018) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

Effect of Radix isatidis polysaccharide on alleviating insulin resistance in type 2 diabetes mellitus cells and rats

(2018) Ji-ping Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease

(2018) Gina M. Broom et al.   NUTRITION

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

(2017) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons

(2017) Han-Kyu Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction

(2017) Yuri Zilberter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dementia prevention, intervention, and care

(2017) Gill Livingston et al.   LANCET

Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring

(2017) Juan Jose Ramos-Rodriguez et al.   Molecular Neurodegeneration

Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease

(2017) Pedro Cisternas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease

(2017) Rohit Pardeshi et al.   PSYCHONEUROENDOCRINOLOGY

Neuronal control of peripheral insulin sensitivity and glucose metabolism

(2017) Johan Ruud et al.   Nature Communications

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

(2017) Roger J. Mullins et al.   Frontiers in Aging Neuroscience

Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration

(2017) Fei Yin et al.   Frontiers in Aging Neuroscience

Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages

(2017) Bryan J. Neth et al.   Frontiers in Aging Neuroscience

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model

(2017) E Lauretti et al.   Translational Psychiatry

Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans

(2017) Simon Vann Jones et al.   Frontiers in Immunology

An Integrated and Unifying Hypothesis for the Metabolic Basis of Sporadic Alzheimer's Disease

(2017) Adnan Erol   JOURNAL OF ALZHEIMERS DISEASE

Interactions Between Glycogen Synthase Kinase 3β, Protein Kinase B, and Protein Phosphatase 2A in Tau Phosphorylation in Mouse N2a Neuroblastoma Cells

(2017) Xin-Wen Zhou et al.   JOURNAL OF ALZHEIMERS DISEASE

Adiposity, Type 2 Diabetes, and Alzheimer's Disease

(2017) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Is Insulin Resistant Brain State a Central Feature of the Metabolic-Cognitive Syndrome?

(2017) Vincenza Frisardi et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

(2017) Maud Gratuze et al.   Scientific Reports

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

(2016) Teresa Niccoli et al.   CURRENT BIOLOGY

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture

(2016) George L. King et al.   DIABETES

Cerebral cortex: a target and source of insulin?

(2016) Éva A. Csajbók et al.   DIABETOLOGIA

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis

(2016) Pedro Cisternas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus

(2016) Dae Young YOO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

(2016) Russell E. Nicholls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

(2016) Stephen C. Cunnane et al.   Frontiers in Molecular Neuroscience

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

(2016) Pei Shi Ong et al.   Frontiers in Pharmacology

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease

(2015) Zhen Fan et al.   BRAIN

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway

(2015) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

(2015) C.-C. Liu et al.   JOURNAL OF NEUROSCIENCE

The role of fatty acids in insulin resistance

(2015) Barry Sears et al.   Lipids in Health and Disease

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice

(2015) Sergi Bayod et al.   NEUROBIOLOGY OF AGING

Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?

(2015) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Noradrenergic dysfunction in Alzheimer's disease

(2015) Mary Gannon et al.   Frontiers in Neuroscience

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

(2014) Wei Qiao Qiu et al.   Frontiers in Aging Neuroscience

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Metabolic Basis of Sporadic Alzeimer’s Disease. Role of Hormones Related to Energy Metabolism

(2013) Jaume Folch et al.   CURRENT PHARMACEUTICAL DESIGN

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

(2013) Rasoul Ghasemi et al.   MOLECULAR NEUROBIOLOGY

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase

(2013) S. R. Hubbard   Cold Spring Harbor Perspectives in Biology

TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists

(2013) M V Blagosklonny   Cell Death & Disease

Insulin resistance in the brain: An old-age or new-age problem?

(2012) Ritchie Williamson et al.   BIOCHEMICAL PHARMACOLOGY

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

(2012) Sónia C. Correia et al.   BRAIN RESEARCH

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways

(2012) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance in the nervous system

(2012) Bhumsoo Kim et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Actions of β-Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

(2011) Jack H. Jhamandas et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

(2011) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Insulin resistance due to nutrient excess

(2011) Asish K. Saha et al.   CELL CYCLE

Nuclear receptors as therapeutic targets for Alzheimer's disease

(2011) Shweta Mandrekar-Colucci et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Response of Human Oligodendrocyte Progenitors to Growth Factors and Axon Signals

(2010) Qiao Ling Cui et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS

Adipose tissue fatty acid metabolism in insulin-resistant men

(2008) A. S. T. Bickerton et al.   DIABETOLOGIA

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

(2008) Yun-An Lim et al.   FEBS LETTERS

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

(2008) C. Hugh Reynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Inflammation and White Matter Damage in Vascular Cognitive Impairment

(2008) G. A. Rosenberg   STROKE

Hippocampal hypometabolism predicts cognitive decline from normal aging

(2007) Lisa Mosconi et al.   NEUROBIOLOGY OF AGING