mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
Authors
Keywords
-
Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 56, Issue 3, Pages 1015-1036
Publisher
IOS Press
Online
2016-12-30
DOI
10.3233/jad-161029
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- p70 S6 Kinase and Tau in Alzheimer's Disease
- (2017) Jin-Jing Pei et al. JOURNAL OF ALZHEIMERS DISEASE
- Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells
- (2015) Bumsup Kwon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- mTor mediates tau localization and secretion: Implication for Alzheimer's disease
- (2015) Zhi Tang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin
- (2015) Bumsup Kwon et al. BIOCHIMIE
- Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy
- (2015) Satoru Kobayashi BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease
- (2015) Dimitrios Kapogiannis et al. FASEB JOURNAL
- Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
- (2015) Antonella Tramutola et al. JOURNAL OF NEUROCHEMISTRY
- Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment
- (2015) Sylvia E. Perez et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches
- (2015) Kalpita Banerjee et al. NEUROCHEMICAL RESEARCH
- mTOR in Brain Physiology and Pathologies
- (2015) Joël Bockaert et al. PHYSIOLOGICAL REVIEWS
- Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
- (2014) Marzia Perluigi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
- (2014) Bumsup Kwon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature
- (2014) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- mTor Is a Signaling Hub in Cell Survival: A Mass-Spectrometry-Based Proteomics Investigation
- (2014) Zhi Tang et al. JOURNAL OF PROTEOME RESEARCH
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
- (2013) Antonella Caccamo et al. AGING CELL
- Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease
- (2013) Lixi Li et al. Current Alzheimer Research
- Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism
- (2013) L. Salvadó et al. DIABETOLOGIA
- PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
- (2013) Cora O' Neill EXPERIMENTAL GERONTOLOGY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease
- (2012) Cora O'Neill et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
- (2012) Maria J. Pereira et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Roles of AMP-activated Protein Kinase in Alzheimer’s Disease
- (2012) Zhiyou Cai et al. NEUROMOLECULAR MEDICINE
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- (2012) Lan Ye et al. Frontiers in Genetics
- Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?
- (2011) Sónia C. Correia et al. AGEING RESEARCH REVIEWS
- Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
- (2011) Smita Majumder et al. AGING CELL
- Insulin resistance and Alzheimer's disease
- (2011) Suzanne M. De La Monte BMB Reports
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
- (2011) Craig A. Goodman et al. CELLULAR SIGNALLING
- Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism
- (2011) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model
- (2011) Sebastian Jimenez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- (2011) Wenjing Guo et al. JOURNAL OF NEUROSCIENCE RESEARCH
- mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells
- (2011) E. A. Goncharova et al. MOLECULAR AND CELLULAR BIOLOGY
- Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons
- (2011) Michelle S. Mazei-Robison et al. NEURON
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
- (2011) Loredana Stoica et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
- (2011) Jessica J. Howell et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- AMPK inhibition in health and disease
- (2010) Benoit Viollet et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein homeostasis and aging in neurodegeneration
- (2010) Peter M. Douglas et al. JOURNAL OF CELL BIOLOGY
- Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
- (2010) C A Sparks et al. ONCOGENE
- The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
- (2010) C. Kenyon PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
- (2010) Hiyaa Singhee Ghosh et al. PLoS One
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2010) Tao Ma et al. PLoS One
- Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
- (2009) Ehud Cohen et al. CELL
- Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
- (2009) Valérie Risson et al. JOURNAL OF CELL BIOLOGY
- PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease
- (2009) Milena Morel et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Amyloid-β interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons
- (2009) Tsan-Ju Chen et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function
- (2009) Kenneth M. Rosen et al. JOURNAL OF NEUROSCIENCE RESEARCH
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid
- (2009) Han-Kyu Lee et al. MOLECULAR BIOLOGY OF THE CELL
- The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
- (2009) Kiran Bhaskar et al. Molecular Neurodegeneration
- AMPK in Health and Disease
- (2009) Gregory R. Steinberg et al. PHYSIOLOGICAL REVIEWS
- Direct control of mitochondrial function by mTOR
- (2009) Arvind Ramanathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TOR complex 2: a signaling pathway of its own
- (2009) Nadine Cybulski et al. TRENDS IN BIOCHEMICAL SCIENCES
- mTOR signaling: At the crossroads of plasticity, memory and disease
- (2009) Charles A. Hoeffer et al. TRENDS IN NEUROSCIENCES
- Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
- (2008) Wei-Qin Zhao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- mTOR-dependent signalling in Alzheimer's disease
- (2008) Jin-Jing Pei et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Role of mTOR in physiology and pathology of the nervous system
- (2007) Lukasz Swiech et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors
- (2007) Jonathan J. Abbott et al. NEUROBIOLOGY OF AGING
- Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease
- (2007) Milena Damjanac et al. NEUROBIOLOGY OF DISEASE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started