Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

Tau Aggregates: Toxic, Inert, or Protective Species?

(2017) Alexis Bretteville et al.   JOURNAL OF ALZHEIMERS DISEASE

GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease

(2017) Yazhou Li et al.   JOURNAL OF ALZHEIMERS DISEASE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

(2014) Franck R. Petry et al.   PLoS One

Insulin dysfunction and Tau pathology

(2014) Noura B. El Khoury et al.   Frontiers in Cellular Neuroscience

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity

(2013) Xiaolan Wang et al.   NEUROTOXICOLOGY

Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

(2012) Antonio Currais et al.   AGING CELL

Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of   Protein Following Onset of Diabetes in NOD Mice

(2012) M.-A. Papon et al.   DIABETES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

(2012) Amit Gupta et al.   MOLECULAR BIOLOGY OF THE CELL

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation

(2012) Carl Julien et al.   PLoS One

Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

(2012) Alexis Bretteville et al.   Scientific Reports

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

(2010) Peter R. Moult et al.   Cell Adhesion & Migration

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

(2009) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH