TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
Authors
Keywords
-
Journal
Cell Death & Disease
Volume 4, Issue 12, Pages e964-e964
Publisher
Springer Nature
Online
2013-12-13
DOI
10.1038/cddis.2013.506
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Growth and aging: a common molecular mechanism
- (2016) Mikhail V. Blagosklonny et al. Aging-US
- mTOR's role in ageing: protein synthesis or autophagy?
- (2016) Sarah L. Hands et al. Aging-US
- Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
- (2016) Mikhail V. Blagosklonny Aging-US
- Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
- (2016) Simon P. Mooijaart et al. Aging-US
- TP53 and MTOR crosstalk to regulate cellular senescence
- (2016) Lorenzo Galluzzi et al. Aging-US
- Type 2 Diabetes and the Aging Pancreatic Beta Cell
- (2016) Uma Gunasekaran et al. Aging-US
- Health and function of participants in the Long Life Family Study: A comparison with other cohorts
- (2016) Anne B. Newman et al. Aging-US
- Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
- (2016) Vjekoslav Dulic Aging-US
- Normalizing a hyperactive mTOR initiates muscle growth during obesity
- (2016) David L. Williamson et al. Aging-US
- Rapamycin: Killing two birds with one stone
- (2016) Amit Khanna et al. Aging-US
- Intermittent supplementation with rapamycin as a dietary restriction mimetic
- (2016) Valter D Longo et al. Aging-US
- Molecular damage in cancer: an argument for mTOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Reversing the aging stromal phenotype prevents carcinoma initiation
- (2016) Davina A. Lewis et al. Aging-US
- Gerosuppressant Metformin: less is more
- (2016) Javier A. Menendez et al. Aging-US
- Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression
- (2016) Olga V. Leontieva et al. Aging-US
- Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective
- (2016) Robi Tacutu et al. Aging-US
- Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex
- (2016) Philippe Major Aging-US
- If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
- (2016) Vladimir N. Anisimov et al. Aging-US
- Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
- (2016) Mikhail V. Blagosklonny Aging-US
- Chemoprevention of age-related macular regeneration (AMD) with rapamycin
- (2016) X. F. Steven Zheng Aging-US
- Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
- (2016) Mikhail V. Blagosklonny Aging-US
- Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
- (2016) Lawrence A. Donehower Aging-US
- Answering the ultimate question “What is the Proximal Cause of Aging?”
- (2016) Mikhail V. Blagosklonny Aging-US
- Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
- (2016) Olga V. Leontieva et al. Aging-US
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- (2016) Elena A. Komarova et al. Aging-US
- Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
- (2016) H. Dorota Halicka et al. Aging-US
- NF90 coordinately represses the senescence-associated secretory phenotype
- (2016) Kumiko Tominaga-Yamanaka et al. Aging-US
- How to save Medicare: the anti-aging remedy
- (2016) Mikhail V. Blagosklonny Aging-US
- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- (2016) Maria Comas et al. Aging-US
- Metformin in obesity, cancer and aging: addressing controversies
- (2016) Lev M. Berstein Aging-US
- Inflammatory cause of metabolic syndrome via brain stress and NF-κB
- (2016) Dongsheng Cai et al. Aging-US
- Inflammaging: disturbed interplay between autophagy and inflammasomes
- (2016) Antero Salminen et al. Aging-US
- Prolonged Rapamycin treatment led to beneficial metabolic switch
- (2016) Yimin Fang et al. Aging-US
- Rapamycin suppresses brain aging in senescence-accelerated OXYS rats
- (2016) Nataliya G. Kolosova et al. Aging-US
- Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
- (2016) Lan Ye et al. Aging-US
- Metformin, aging and cancer
- (2016) Olga Moiseeva et al. Aging-US
- Rapamycin extends life- and health span because it slows aging
- (2016) Mikhail V. Blagosklonny Aging-US
- Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development
- (2016) Yueyong Liu et al. Aging-US
- Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
- (2015) Joan T. Garrett et al. Oncotarget
- NCI’s provocative questions on cancer: some answers to ignite discussion
- (2015) Mikhail V. Blagosklonny Oncotarget
- Metformin: Multi-faceted protection against cancer
- (2015) Sonia Del Barco et al. Oncotarget
- Exploiting the mTOR paradox for disease prevention
- (2015) Ramiro Iglesias-Bartolome et al. Oncotarget
- Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI’s provocative questions
- (2015) Mikhail V. Blagosklonny Oncotarget
- The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer
- (2015) Nicolas Floc'h et al. Oncotarget
- PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes
- (2015) Filip Janku et al. Oncotarget
- The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway
- (2015) Arnold J. Levine et al. Oncotarget
- Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
- (2013) Dudley W. Lamming et al. AGING CELL
- Late-life rapamycin treatment reverses age-related heart dysfunction
- (2013) James M. Flynn et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- MEK drives cyclin D1 hyperelevation during geroconversion
- (2013) O V Leontieva et al. CELL DEATH AND DIFFERENTIATION
- mTOR in aging, metabolism, and cancer
- (2013) Marion Cornu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B
- (2013) J Chen et al. Cell Death & Disease
- Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
- (2013) O V Leontieva et al. Cell Death & Disease
- Rapamycin slows aging in mice
- (2012) John E. Wilkinson et al. AGING CELL
- Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment
- (2012) Isabelle Mercier et al. AMERICAN JOURNAL OF PATHOLOGY
- Prospective Treatment of Age-Related Diseases by Slowing Down Aging
- (2012) Mikhail V. Blagosklonny AMERICAN JOURNAL OF PATHOLOGY
- Prevention of Age-Related Macular Degeneration–Like Retinopathy by Rapamycin in Rats
- (2012) Nataliya G. Kolosova et al. AMERICAN JOURNAL OF PATHOLOGY
- Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
- (2012) David Gems et al. Annual Review of Physiology
- Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?
- (2012) David Gems et al. ANTIOXIDANTS & REDOX SIGNALING
- Rapalogs in cancer prevention
- (2012) Mikhail V. Blagosklonny CANCER BIOLOGY & THERAPY
- Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
- (2012) Mikhail V Blagosklonny CELL CYCLE
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
- (2012) Vladimir N. Anisimov et al. CELL CYCLE
- Autophagy and cardiovascular aging
- (2012) Sreejayan Nair et al. CELL CYCLE
- Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
- (2012) Olga V. Leontieva et al. CELL CYCLE
- C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells
- (2012) F Allagnat et al. CELL DEATH AND DIFFERENTIATION
- Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
- (2012) Cecilia A. Hinojosa et al. EXPERIMENTAL GERONTOLOGY
- Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
- (2012) J. Halloran et al. NEUROSCIENCE
- Hypoxia suppresses conversion from proliferative arrest to cellular senescence
- (2012) O. V. Leontieva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
- (2012) J Cahu et al. Cell Death & Disease
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
- (2011) N Deblon et al. BRITISH JOURNAL OF PHARMACOLOGY
- Rapamycin decelerates cellular senescence
- (2011) Zoya N. Demidenko et al. CELL CYCLE
- Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)
- (2011) Mikhail V Blagosklonny CELL CYCLE
- The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1α
- (2011) Zoya N. Demidenko et al. CELL CYCLE
- Insulin resistance due to nutrient excess
- (2011) Asish K. Saha et al. CELL CYCLE
- TOR in the immune system
- (2011) Koichi Araki et al. CURRENT OPINION IN CELL BIOLOGY
- Activation of Protein Kinase C- in Pancreatic -Cells In Vivo Improves Glucose Tolerance and Induces -Cell Expansion via mTOR Activation
- (2011) S. Velazquez-Garcia et al. DIABETES
- Subconjunctival sirolimus in the treatment of diabetic macular edema
- (2011) Nupura Krishnadev et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Chronically Increased S6K1 Is Associated with Impaired IRS1 Signaling in Skeletal Muscle of GDM Women with Impaired Glucose Tolerance Postpartum
- (2011) Linda A. Barbour et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
- (2011) Shi-Bing Yang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
- (2011) J. Guevara-Aguirre et al. Science Translational Medicine
- Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
- (2011) T Tomic et al. Cell Death & Disease
- Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
- (2010) Vladimir N. Anisimov et al. AMERICAN JOURNAL OF PATHOLOGY
- Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: a cross-sectional study
- (2010) J. D. Ellis et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Growth stimulation leads to cellular senescence when the cell cycle is blocked
- (2010) Zoya N. Demidenko et al. CELL CYCLE
- Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis
- (2010) F Allagnat et al. CELL DEATH AND DIFFERENTIATION
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Decreased IRS Signaling Impairs -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in -Cells
- (2010) L. Elghazi et al. DIABETES
- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
- (2010) V. P. Houde et al. DIABETES
- Glycemic Thresholds for Diabetes-Specific Retinopathy: Implications for diagnostic criteria for diabetes
- (2010) S. Colagiuri et al. DIABETES CARE
- Glucose regulation of β-cell stress in type 2 diabetes
- (2010) G. Leibowitz et al. DIABETES OBESITY & METABOLISM
- Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
- (2010) Yvonne Fierz et al. ENDOCRINE-RELATED CANCER
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Paradoxical suppression of cellular senescence by p53
- (2010) Z. N. Demidenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
- (2010) M V Blagosklonny Cell Death & Disease
- Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy
- (2009) Christopher H. Gibbons et al. ANNALS OF NEUROLOGY
- Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study
- (2009) Tien-I Karleen Su et al. ARTHRITIS AND RHEUMATISM
- Long-term Administration of Rapamycin Reduces Adiposity, but Impairs Glucose Tolerance in High-Fat Diet-fed KK/HlJ Mice
- (2009) Geng-Ruei Chang et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Successful Control of Intractable Hypoglycemia Using Rapamycin in an 86-Year-Old Man with a Pancreatic Insulin-Secreting Islet Cell Tumor and Metastases
- (2009) Matthew E. Bourcier et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Glycemic Control in Patients with Insulinoma Treated with Everolimus
- (2009) Matthew H. Kulke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Downregulation of Serum IGF-1 for Treatment of Early Worsening of Diabetic Retinopathy: A Long-Term Follow-Up of Two Cases
- (2009) Ernst Chantelau et al. OPHTHALMOLOGICA
- Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1
- (2009) Etti Bachar et al. PLoS One
- Sirolimus Therapy for Patients With Adult Polycystic Kidney Disease: A Pilot Study
- (2009) A.R. Soliman et al. TRANSPLANTATION PROCEEDINGS
- A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
- (2008) Erin L. Glynn et al. Applied Physiology Nutrition and Metabolism
- Biphasic Response of Pancreatic -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice
- (2008) Y. Shigeyama et al. MOLECULAR AND CELLULAR BIOLOGY
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started