Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

Time Course of Glucose Metabolism in Relation to Cognitive Performance and Postmortem Neuropathology in Met146Val PSEN1 Mutation Carriers

(2018) Michael Schöll et al.   JOURNAL OF ALZHEIMERS DISEASE

Sporadic Alzheimer's Disease: The Starving Brain

(2018) Mortimer Mamelak   JOURNAL OF ALZHEIMERS DISEASE

Lower Brain 18F-Fluorodeoxyglucose Uptake But Normal 11C-Acetoacetate Metabolism in Mild Alzheimer's Disease Dementia

(2018) Christian-Alexandre Castellano et al.   JOURNAL OF ALZHEIMERS DISEASE

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Temporal Lobe Atrophy May Be Underrecognized in Older Patients with New-Onset Epilepsy

(2016) Emmanuelle Lapointe et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome

(2016) D. Aled Rees et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure

(2016) Heather M. Wilkins et al.   JOURNAL OF NEUROCHEMISTRY

Ketones block amyloid entry and improve cognition in an Alzheimer's model

(2016) Jun Xiang Yin et al.   NEUROBIOLOGY OF AGING

Preliminary evaluation of a differential effect of an α-linolenate-rich supplement on ketogenesis and plasma ω-3 fatty acids in young and older adults

(2016) Marie Hennebelle et al.   NUTRITION

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

(2015) Mary T. Newport et al.   Alzheimers & Dementia

Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype?

(2015) S. Nugent et al.   BIOGERONTOLOGY

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure

(2015) Andrea Viggiano et al.   BRAIN RESEARCH

Rapid Adaptation of Rat Brain and Liver Metabolism to a Ketogenic Diet: An Integrated Study Using 1H- and 13C-NMR Spectroscopy

(2015) Maggie Roy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

(2015) Leif Hertz et al.   JOURNAL OF NEUROCHEMISTRY

Relationship Between Alzheimer Disease-Like Pattern of 18F-FDG and Fasting Plasma Glucose Levels in Cognitively Normal Volunteers

(2015) K. Ishibashi et al.   JOURNAL OF NUCLEAR MEDICINE

Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans

(2015) Alexandre Courchesne-Loyer et al.   NUTRITION

Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance

(2015) Christian-Alexandre Castellano et al.   PLoS One

Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults

(2014) Scott Nugent et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution

(2014) Stephen C. Cunnane et al.   JOURNAL OF HUMAN EVOLUTION

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Triheptanoin for Glucose Transporter Type I Deficiency (G1D)

(2014) Juan M. Pascual et al.   JAMA Neurology

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain glucose and acetoacetate metabolism: a comparison of young and older adults

(2013) Scott Nugent et al.   NEUROBIOLOGY OF AGING

Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions

(2013) C. M. Burns et al.   NEUROLOGY

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

The ketogenic diet increases brain glucose and ketone uptake in aged rats: A dual tracer PET and volumetric MRI study

(2012) Maggie Roy et al.   BRAIN RESEARCH

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Insulin resistance and AD—extending the translational path

(2012) Suzanne Craft   Nature Reviews Neurology

Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism

(2012) Alexandre Courchesne-Loyer et al.   NUTRITION

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

(2011) Helgi B. Schiöth et al.   MOLECULAR NEUROBIOLOGY

Mild experimental ketosis increases brain uptake of11C-acetoacetate and18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats

(2011) Fabien Pifferi et al.   NUTRITIONAL NEUROSCIENCE

Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids

(2010) Ulla Lying-Tunell et al.   ACTA NEUROLOGICA SCANDINAVICA

OXIDATION OF GLUCOSE and D-B-OH-BUTYRATE BY THE EARLY HUMAN FETAL BRAIN

(2010) PETER A. J. ADAM et al.   ACTA PAEDIATRICA

A New Approach to Treating Alzheimer's Disease

(2010) John P. Blass   Annals of the New York Academy of Sciences

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington's disease

(2010) Fanny Mochel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Dietary ketosis enhances memory in mild cognitive impairment

(2010) Robert Krikorian et al.   NEUROBIOLOGY OF AGING

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

(2009) K. A. Page et al.   DIABETES

Metabolic response to a ketogenic breakfast in the healthy elderly

(2009) E. Freemantle et al.   Journal of Nutrition Health & Aging

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS

Adipose tissue fatty acid metabolism in insulin-resistant men

(2008) A. S. T. Bickerton et al.   DIABETOLOGIA

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY

Ketone bodies as a therapeutic for Alzheimer’s disease

(2008) Samuel T. Henderson   Neurotherapeutics

Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging

(2007) Grégoria Kalpouzos et al.   NEUROBIOLOGY OF AGING

Measurement of β-hydroxybutyrate in acute hyperketonemia in human brain

(2003) J. W. Pan et al.   JOURNAL OF NEUROCHEMISTRY