Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

Insulin is a Two-Edged Knife on the Brain

(2017) Susana Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress in Diabetes and Alzheimer's Disease

(2017) V. Prakash Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

(2017) Paula I. Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin Levels are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease

(2017) Francisco J. Gil-Bea et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting IL-1 in depression

(2012) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture

(2012) Tina Sartorius et al.   FASEB JOURNAL

Hyperglycemic Chorea-Ballism or Acute Exacerbation of Huntington's Chorea? Huntington's Disease Unmasked by Diabetic Ketoacidosis in Type 1 Diabetes Mellitus

(2012) Ken-ichi Hashimoto et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The metabolic syndrome in schizophrenia: is inflammation a contributing cause?

(2012) Brian E Leonard et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia

(2012) Matej Orešič et al.   Genome Medicine

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

(2011) Christian Hölscher   BIOCHEMICAL SOCIETY TRANSACTIONS

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease

(2011) Maddalena Napolitano et al.   BRAIN RESEARCH BULLETIN

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Diabetes and the Risk of Developing Parkinson's Disease in Denmark

(2011) E. Schernhammer et al.   DIABETES CARE

Diabetes and Risk of Parkinson's Disease

(2011) Q. Xu et al.   DIABETES CARE

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease

(2011) A.I. Duarte et al.   EXPERIMENTAL NEUROLOGY

Insulin resistance impairs nigrostriatal dopamine function

(2011) J.K. Morris et al.   EXPERIMENTAL NEUROLOGY

No Effect of Single-Dose Intranasal Insulin Treatment on Verbal Memory and Sustained Attention in Patients With Schizophrenia

(2011) Xiaoduo Fan et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation

(2011) Yi-Fang Tu et al.   Journal of Neuroinflammation

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

(2011) Christine R Swanson et al.   Journal of Neuroinflammation

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats

(2011) Harikesh Kalonia et al.   LIFE SCIENCES

The role of immunity in Huntington's disease

(2011) D Soulet et al.   MOLECULAR PSYCHIATRY

New animal models of Parkinson's disease

(2011) Benjamin Dehay et al.   MOVEMENT DISORDERS

The renin-angiotensin system: a link between obesity, inflammation and insulin resistance

(2011) N. S. Kalupahana et al.   Obesity Reviews

Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia

(2011) Paul C. Guest et al.   PSYCHONEUROENDOCRINOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Paeonol Attenuates Microglia-Mediated Inflammation and Oxidative Stress–Induced Neurotoxicity in Rat Primary Microglia and Cortical Neurons

(2011) Yu-Ting Tseng et al.   SHOCK

Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

(2010) Jill K. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bidirectional Association Between Depression and Type 2 Diabetes Mellitus in Women

(2010) An Pan et al.   ARCHIVES OF INTERNAL MEDICINE

Diabetes mellitus in Huntington disease

(2010) Lindsay A. Farrer   CLINICAL GENETICS

Antidepressant Use Before and After the Diagnosis of Type 2 Diabetes: A longitudinal modeling study

(2010) M. Kivimaki et al.   DIABETES CARE

Depression and Insulin Resistance: Cross-sectional associations in young adults

(2010) S. Pearson et al.   DIABETES CARE

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Targeting Glial Cells to Elucidate the Pathogenesis of Huntington’s Disease

(2010) Han-Yun Hsiao et al.   MOLECULAR NEUROBIOLOGY

Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients

(2010) P C Guest et al.   MOLECULAR PSYCHIATRY

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Possible regulatory factors for intra-abdominal fat mass in a rat model of Parkinson's disease

(2010) Sachi Kuranuki et al.   NUTRITION

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance and metabolic profile in antipsychotic naïve schizophrenia patients

(2010) Anindya Dasgupta et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Is Abnormal Glucose Tolerance in Antipsychotic-Naive Patients With Nonaffective Psychosis Confounded by Poor Health Habits?

(2010) B. Kirkpatrick et al.   SCHIZOPHRENIA BULLETIN

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.

(2009) V. Haj-ali et al.   BEHAVIORAL NEUROSCIENCE

Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats

(2009) Jun-Xu Li et al.   BEHAVIOURAL PHARMACOLOGY

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Mutant huntingtin interacts with  -tubulin and disrupts vesicular transport and insulin secretion

(2009) R. Smith et al.   HUMAN MOLECULAR GENETICS

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Huntington’s Disease Does Not Appear to Increase the Risk of Diabetes Mellitus

(2009) T. W. Boesgaard et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Diabetes, microvascular pathology and Alzheimer disease

(2009) Raj N. Kalaria   Nature Reviews Neurology

In vivo electrophysiological effects of insulin in the rat brain

(2009) Peter Kovacs et al.   NEUROPEPTIDES

A critical review of human endotoxin administration as an experimental paradigm of depression

(2009) Nicole DellaGioia et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Psychological symptoms and insulin sensitivity in adolescents

(2009) Lauren B Shomaker et al.   PEDIATRIC DIABETES

Glucose Homeostasis in Huntington Disease

(2008) Nebojša M. Lalić et al.   ARCHIVES OF NEUROLOGY

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin, IGF-1, and Muscarinic Agonists Modulate Schizophrenia-associated Genes in Human Neuroblastoma Cells

(2008) C. Anthony Altar et al.   BIOLOGICAL PSYCHIATRY

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease

(2008) J. A. Driver et al.   DIABETES CARE

Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies

(2008) Kyriaki Gerozissis   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol in islet dysfunction and type 2 diabetes

(2008) Liam R. Brunham et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE

β-Amyloid deposition in brains of subjects with diabetes

(2008) I. Alafuzoff et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Glucoregulation in normal weight schizophrenia patients treated by first generation antipsychotics

(2008) Nadja Maric et al.   Srpski Arhiv za Celokupno Lekarstvo

Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study

(2007) An Pan et al.   JOURNAL OF AFFECTIVE DISORDERS

Hepatic Insulin Resistance in Antipsychotic Naive Schizophrenic Patients: Stable Isotope Studies of Glucose Metabolism

(2007) Lonneke J. M. van Nimwegen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM