Insulin Resistance and Oxidative Stress in the Brain: What’s New?

Glutathione Metabolism, Mitochondria Activity, and Nitrosative Stress in Patients Treated for Mandible Fractures

(2019) Jan Borys et al.   Journal of Clinical Medicine

Insulin resistance in obesity: an overview of fundamental alterations

(2018) Rocco Barazzoni et al.   Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity

The 20-Year Voyage Aboard the Journal of Alzheimer's Disease: Docking at ‘Type 3 Diabetes’, Environmental/Exposure Factors, Pathogenic Mechanisms, and Potential Treatments

(2018) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review

(2018) Konstantinos Ioannis Avgerinos et al.   JOURNAL OF NEUROLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Effect of N-Acetylcysteine on Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in a Rat Model of Insulin Resistance

(2018) Piotr Żukowski et al.   Oxidative Medicine and Cellular Longevity

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

(2018) Christian Benedict et al.   Frontiers in Neuroscience

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

(2018) Gina Cavaliere et al.   Frontiers in Physiology

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Alzheimer Disease

(2018) John E. Morley et al.   CLINICS IN GERIATRIC MEDICINE

Dysfunctional Pro-Ceramide, ER Stress, and Insulin/IGF Signaling Networks with Progression of Alzheimer's Disease

(2018) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance

(2018) Mateusz Maciejczyk et al.   Oxidative Medicine and Cellular Longevity

Whey Protein Concentrate WPC-80 Intensifies Glycoconjugate Catabolism and Induces Oxidative Stress in the Liver of Rats

(2018) Marta Żebrowska-Gamdzyk et al.   Nutrients

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

(2018) Jirapas Sripetchwandee et al.   Frontiers in Endocrinology

Salivary Biomarkers of Oxidative Stress in Children with Chronic Kidney Disease

(2018) Mateusz Maciejczyk et al.   Journal of Clinical Medicine

Eight-Week Consumption of High-Sucrose Diet Has a Pro-Oxidant Effect and Alters the Function of the Salivary Glands of Rats

(2018) Mateusz Maciejczyk et al.   Nutrients

High-fat, high-protein, and high-carbohydrate diets affect sphingolipid profile in pancreatic steatosis in Wistar rats

(2018) Małgorzata Żendzian-Piotrowska et al.   NUTRITION

Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

(2017) Magdalena Choromańska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice

(2017) Jong Min Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Increased total DNA damage and oxidative stress in brain are associated with decreased longevity in high sucrose diet fed WNIN/Gr-Ob obese rats

(2017) Aruna Potukuchi et al.   NUTRITIONAL NEUROSCIENCE

CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance

(2017) Xiaoxiang Tian et al.   PLoS One

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Oxidative Modification in the Salivary Glands of High Fat-Diet Induced Insulin Resistant Rats

(2017) Urszula Kołodziej et al.   Frontiers in Physiology

Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome

(2017) Mateusz Maciejczyk et al.   Redox Biology

Mechanisms of Ceramide-Mediated Neurodegeneration

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Ceramide-Mediated Insulin Resistance and Impairment of Cognitive-Motor Functions

(2017) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation and microglial activation in a streptozotocin-induced Alzheimer’s rat model

(2017) Zhangyu Guo et al.   Scientific Reports

Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus

(2016) Chrysi Koliaki et al.   Annual Review of Nutrition

ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes

(2016) Zheng Sun et al.   BMC Complementary and Alternative Medicine

Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats

(2016) Hiranya Pintana et al.   BRITISH JOURNAL OF NUTRITION

Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

(2016) Candace M. Reno et al.   DIABETES

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

(2016) Eva Baquedano et al.   Disease Models & Mechanisms

Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes

(2016) Caterina Palleria et al.   FRONTIERS IN NEUROENDOCRINOLOGY

FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

(2016) Piangkwan Sa-nguanmoo et al.   HORMONES AND BEHAVIOR

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

(2016) Yunhua Peng et al.   JOURNAL OF NEUROCHEMISTRY

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway

(2016) FangFang et al.   METABOLIC BRAIN DISEASE

Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands

(2016) Jan Matczuk et al.   Journal of Diabetes Research

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

(2016) Xiaoting Luo et al.   Aging and Disease

Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function

(2016) Titikorn Chunchai et al.   Scientific Reports

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells

(2015) Brenda Diaz et al.   BRAIN RESEARCH

Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice

(2015) Dongmei Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain

(2015) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Oxidative and nitrative stress in neurodegeneration

(2015) Catherine A. Cobb et al.   NEUROBIOLOGY OF DISEASE

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

(2015) Zhigang Liu et al.   PLoS One

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor for advanced glycation end-products in neurodegenerative diseases

(2015) Judyta Juranek et al.   REVIEWS IN THE NEUROSCIENCES

Mechanisms Linking Inflammation to Insulin Resistance

(2015) Li Chen et al.   International Journal of Endocrinology

Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins

(2015) Nataša Kopitar-Jerala   Frontiers in Molecular Neuroscience

Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake

(2015) Anne Drougard et al.   Frontiers in Neuroscience

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative-stress induced increase in circulating fatty acids does not contribute to phospholipase A2-dependent appetitive long-term memory failure in the pond snail Lymnaeastagnalis

(2014) Emily Beaulieu et al.   BMC NEUROSCIENCE

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

Free radicals, reactive oxygen species, oxidative stress and its classification

(2014) Volodymyr I. Lushchak   CHEMICO-BIOLOGICAL INTERACTIONS

RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice

(2014) Fei Song et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats

(2014) Graham P. Holloway et al.   DIABETOLOGIA

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity

(2014) Tina Sartorius et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

(2013) Sheree D. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Glutathione Prevents Free Fatty Acids-Induced Oxidative Stress and Apoptosis in Human Brain Vascular Endothelial Cells Through Akt Pathway

(2013) Hou-Guang Zhou et al.   CNS Neuroscience & Therapeutics

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

Impaired Glutathione Synthesis in Neurodegeneration

(2013) Koji Aoyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress and Apoptosis of Human Brain Microvascular Endothelial Cells Induced by Free Fatty Acids

(2013) H Zhou et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease

(2013) Marjorie Bastien et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet

(2012) Jennifer K. Pepping et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Insulin Resistance and Type 2 Diabetes

(2012) R. Taylor   DIABETES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Alcohol, insulin resistance and the liver-brain axis

(2012) Suzanne de la Monte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Energy metabolism of rat cerebral cortex, hypothalamus and hypophysis during ageing

(2012) R.F. Villa et al.   NEUROSCIENCE

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice

(2012) David Porter et al.   PEPTIDES

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Glutathione is a physiologic reservoir of neuronal glutamate

(2011) Minori Koga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid

(2011) Kamal A Amin et al.   Lipids in Health and Disease

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Hypometabolism in Alzheimer-Affected Brain Regions in Cognitively Healthy Latino Individuals Carrying the Apolipoprotein E ε4 Allele

(2010) Jessica B. S. Langbaum et al.   ARCHIVES OF NEUROLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

(2010) K. A. Diggs-Andrews et al.   DIABETES

NOX activity in brain aging: Exacerbation by high fat diet

(2010) Annadora J. Bruce-Keller et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease

(2010) Inelia Morales et al.   NEUROIMMUNOMODULATION

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective neuronal vulnerability to oxidative stress in the brain

(2010) Wang   Frontiers in Aging Neuroscience

Synaptic Mechanisms for Plasticity in Neocortex

(2009) Daniel E. Feldman   Annual Review of Neuroscience

Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies

(2009) S. Del Prato   DIABETIC MEDICINE

Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death

(2009) Arundhati Jana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Correlating Cerebral Hypometabolism With Future Memory Decline in Subsequent Converters to Amnestic Pre–Mild Cognitive Impairment

(2008) Richard J. Caselli et al.   ARCHIVES OF NEUROLOGY

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

(2008) Gonzalo Arboleda et al.   BRAIN RESEARCH REVIEWS

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair

(2008) Thomas. J. Nelson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatic triacylglycerol accumulation and insulin resistance

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING