Hedgehog Signaling and Truncated GLI1 in Cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary

(2020) Smarakan Sneha et al.   CELLULAR ONCOLOGY

Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

(2020) Harman Saman et al.   Cancers

GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression

(2020) Ezequiel Tolosa et al.   BIOCHEMICAL JOURNAL

A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents

(2020) Brilliant N. Marak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases

(2020) Gizem Celebi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer

(2019) Richard L. Carpenter et al.   DRUG SAFETY

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

(2019) Nikki K. Lytle et al.   CELL

FDA Approval Summary: Glasdegib for newly-diagnosed acute myeloid leukemia

(2019) Kelly J. Norsworthy et al.   CLINICAL CANCER RESEARCH

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

(2019) Hongwu Qian et al.   Nature Communications

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling

(2019) Christiane Kowatsch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

(2019) Sherona R. Sirkisoon et al.   ONCOGENE

Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle

(2019) Alla Piirsoo et al.   PLoS One

Mutation of the PTCH1 gene predicts recurrence of breast cancer

(2019) Chih-Yang Wang et al.   Scientific Reports

HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway

(2018) Wei Yang et al.   CANCER LETTERS

Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44

(2018) Tadas K. Rimkus et al.   CANCER RESEARCH

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

(2018) Syeda Kiran Riaz et al.   Cell Communication and Signaling

Vascular endothelial growth factor signaling in development and disease

(2018) Sinem Karaman et al.   DEVELOPMENT

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Targeting GLI Transcription Factors in Cancer

(2018) Miroslava Didiasova et al.   MOLECULES

Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer

(2018) Sherona R. Sirkisoon et al.   ONCOGENE

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Anti-Angiogenics: Current Situation and Future Perspectives

(2018) Katja Zirlik et al.   Oncology Research and Treatment

Identification of novel GLI1 target genes and regulatory circuits in human cancer cells

(2018) Yumei Diao et al.   Molecular Oncology

Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia

(2018) Lan Ho Wei et al.   PLoS One

Forkhead box C1 boosts triple-negative breast cancer metastasis through activating the transcription of chemokine receptor-4

(2018) Hongchao Pan et al.   CANCER SCIENCE

LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription

(2018) Amar N. Mirza et al.   CELL

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

(2018) Laura Antonucci et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity

(2018) Shamik Das et al.   LABORATORY INVESTIGATION

Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells

(2018) Ita Novita Sari et al.   Cells

Breast cancer stem cells: Biology and therapeutic implications

(2018) Ramesh Butti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DeSUMOylation of Gli1 by SENP1 Attenuates Sonic Hedgehog Signaling

(2017) Huaize Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

(2017) A Po et al.   ONCOGENE

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

(2017) Yoshikazu Koike et al.   Breast Cancer

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

(2017) Rui Zhang et al.   Oncotarget

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness

(2017) Bárbara S. Casas et al.   Oncotarget

Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study

(2017) Qi Wu et al.   Oncotarget

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

(2017) Sonia Coni et al.   Scientific Reports

A Recurrent Mosaic Mutation in SMO , Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome

(2016) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis

(2016) Zheng-qiang Liao et al.   BMB Reports

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog

(2016) Hanna Tukachinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence

(2016) Justin M. Balko et al.   Science Translational Medicine

Aflibercept, a New Way to Target Angiogenesis in the Second Line Treatment of Metastatic Colorectal Cancer (mCRC)

(2016) Mario Scartozzi et al.   Targeted Oncology

Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells

(2016) Xiaodong Li et al.   Oncotarget

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

(2016) Laura Di Magno et al.   Oncotarget

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

(2016) A. S. Noman et al.   Scientific Reports

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth

(2015) S Pandolfi et al.   CELL DEATH AND DIFFERENTIATION

Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression

(2015) Jianfei Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOX9 inhibits  -TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties

(2015) W. Deng et al.   JOURNAL OF CELL SCIENCE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells

(2015) Y-H Fan et al.   ONCOGENE

Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

(2015) Yuhong Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Regulating Protein Localization

(2015) Nicholas C. Bauer et al.   TRAFFIC

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

(2015) Philipp Schneider et al.   Nature Communications

Cancer stem cell targeted therapy: progress amid controversies

(2015) Tao Wang et al.   Oncotarget

Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma

(2015) Vishnu C. Ramani et al.   Oncotarget

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

(2015) Murielle Mimeault et al.   Oncotarget

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells

(2015) Shingo Inaguma et al.   Oncotarget

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

(2015) Narinder Sharma et al.   Oncotarget

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma

(2015) Yen-Hsing Li et al.   Cell Reports

A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma

(2015) X Shi et al.   Oncogenesis

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(2015) Namrata Bora-Singhal et al.   NEOPLASIA

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

The potential of heparanase as a therapeutic target in cancer

(2014) Claudio Pisano et al.   BIOCHEMICAL PHARMACOLOGY

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

(2014) Monica D. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

(2014) Hansjochen Wilke et al.   LANCET ONCOLOGY

PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma

(2014) T. Saito et al.   MUTAGENESIS

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator

(2014) Qing Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth

(2013) Hu Zhu et al.   CANCER LETTERS

Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

(2013) M. Malatesta et al.   CANCER RESEARCH

GLI1 Interferes with the DNA Mismatch Repair System in Pancreatic Cancer through BHLHE41-Mediated Suppression of MLH1

(2013) S. Inaguma et al.   CANCER RESEARCH

Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia

(2013) S. Katagiri et al.   CLINICAL CANCER RESEARCH

Essential Role of Gli Proteins in Glioblastoma Multiforme

(2013) Matteo Santoni et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

GLI1 finds a new role in cancer stem cell biology

(2013) Martin E. Fernandez-Zapico   EMBO Molecular Medicine

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

(2013) Luis A. Milla et al.   INTERNATIONAL JOURNAL OF CANCER

Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial

(2013) Charles S Fuchs et al.   LANCET

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

(2013) Guiomar Solanas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

(2013) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

(2013) J. M. Balko et al.   Cancer Discovery

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

(2012) S. Blotta et al.   BLOOD

Hedgehog pathway activation in human transitional cell carcinoma of the bladder

(2012) G Pignot et al.   BRITISH JOURNAL OF CANCER

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Glioblastoma cancer stem cells – From concept to clinical application

(2012) Barbara E. Stopschinski et al.   CANCER LETTERS

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

(2012) Cuiping Yang et al.   CELL RESEARCH

Cancer stem cell hypothesis: a brief summary and two proposals

(2012) Shuhua Zheng et al.   CYTOTECHNOLOGY

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

(2012) Xiang Jiao et al.   GENES CHROMOSOMES & CANCER

Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors

(2012) A Ikegame et al.   LEUKEMIA

STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation With STAT3

(2012) Woody Han et al.   MOLECULAR CARCINOGENESIS

Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium

(2012) Nikè V. J. A. Büller et al.   PHYSIOLOGY

Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant

(2012) Ulrica Tostar et al.   PLoS One

Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b

(2012) Maria Karlou et al.   PROSTATE

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

(2011) David W. Ellison et al.   ACTA NEUROPATHOLOGICA

Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer

(2011) S. A. O'Toole et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations

(2011) Fei Tian et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

(2011) H. Wong et al.   CLINICAL CANCER RESEARCH

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the hedgehog pathway in chronic myelogeneous leukemia patients

(2011) Bing Long et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

(2011) B G Mar et al.   LEUKEMIA

Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

(2011) Rebecca A. Ihrie et al.   NEURON

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells

(2011) X Cao et al.   ONCOGENE

Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells

(2011) X Wang et al.   ONCOGENE

ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma

(2011) R R Singh et al.   ONCOGENE

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

(2011) Michel Bidet et al.   PLoS One

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer

(2011) ShanShan He et al.   PLoS One

Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

(2011) Brahma N. Singh et al.   PLoS One

The RND-family transporter, HpnN, is required for hopanoid localization to the outer membrane of Rhodopseudomonas palustris TIE-1

(2011) D. M. Doughty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development

(2011) X. Zhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

(2010) Mehdi H Shahi et al.   BMC CANCER

Non-consensus GLI binding sites in Hedgehog target gene regulation

(2010) Martina Winklmayr et al.   BMC MOLECULAR BIOLOGY

Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

(2010) T. Mazumdar et al.   CANCER RESEARCH

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

(2010) Pilar Chinchilla et al.   CELL CYCLE

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases

(2010) Hu Zhu et al.   CURRENT GENOMICS

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

(2010) Hong Chang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway

(2010) Alla Maloverjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Critical molecular pathways in cancer stem cells of chronic myeloid leukemia

(2010) Y Chen et al.   LEUKEMIA

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

(2010) S Inaguma et al.   ONCOGENE

SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors

(2010) Barny Cox et al.   PLoS One

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

(2010) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

GDC-0449—A potent inhibitor of the hedgehog pathway

(2009) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gli1 promotes cell survival and is predictive of a poor outcome in ERα-negative breast cancer

(2009) Lusheng Xu et al.   BREAST CANCER RESEARCH AND TREATMENT

Paracrine Hedgehog Signaling in Cancer

(2009) J.-W. Theunissen et al.   CANCER RESEARCH

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Hedgehog signalling in colon cancer and stem cells

(2009) Alberto Gulino et al.   EMBO Molecular Medicine

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

(2009) Alla Maloverjan et al.   EXPERIMENTAL CELL RESEARCH

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

(2009) L Yang et al.   ONCOGENE

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas

(2008) O. J. Becher et al.   CANCER RESEARCH

Identification of the gene transcription repressor domain of Gli3

(2008) Robert Tsanev et al.   FEBS LETTERS

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes

(2008) Joon Won Yoon et al.   INTERNATIONAL JOURNAL OF CANCER

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal

(2008) Takashi Shimokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target

(2008) G. V. Hegde et al.   MOLECULAR CANCER RESEARCH

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE

CD24 induces localization of β1 integrin to lipid raft domains

(2007) Steffen Runz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS