Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

Hedgehog Pathway Inhibitor HhAntag691 Is a Potent Inhibitor of ABCG2/BCRP and ABCB1/Pgp

(2015) Yimao Zhang et al.   NEOPLASIA

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

Development of Mammary Tumors by Conditional Expression of GLI1

(2009) M. Fiaschi et al.   CANCER RESEARCH

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

Hedgehog signalling in breast cancer

(2009) M. Kasper et al.   CARCINOGENESIS

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

(2009) Jie Gao et al.   Cell Stem Cell

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

(2009) Inga Hofmann et al.   Cell Stem Cell

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

(2009) Jinping Jia et al.   DEVELOPMENTAL BIOLOGY

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

(2009) Christopher W. Wilson et al.   NATURE

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

A small molecule that binds Hedgehog and blocks its signaling in human cells

(2009) Benjamin Z Stanton et al.   Nature Chemical Biology

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes

(2009) S Laner-Plamberger et al.   ONCOGENE

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

(2009) J M Bailey et al.   ONCOGENE

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Implications of hedgehog signaling antagonists for cancer therapy

(2008) Jingwu Xie   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana

(2008) Midori A. Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy

(2008) R Yoshikawa et al.   BRITISH JOURNAL OF CANCER

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

(2008) Greg Shaw et al.   Cancer Cell International

Crosstalk of hedgehog and Wnt pathways in gastric cancer

(2008) Kosuke Yanai et al.   CANCER LETTERS

Stroma-Initiated Hedgehog Signaling Takes Center Stage in B-Cell Lymphoma

(2008) R. K. Lindemann   CANCER RESEARCH

SCL/TAL1 Interrupting Locus Derepresses GLI1 from the Negative Control of Suppressor-of-Fused in Pancreatic Cancer Cell

(2008) K. Kasai et al.   CANCER RESEARCH

Insulin-like Growth Factor 2Is Required for Progression to Advanced Medulloblastoma inpatched1Heterozygous Mice

(2008) Ryan B. Corcoran et al.   CANCER RESEARCH

The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread

(2008) B. A. Hatton et al.   CANCER RESEARCH

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

(2008) Xiaoyun Liao et al.   CARCINOGENESIS

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription

(2008) Takahiro Hosoya et al.   CHEMBIOCHEM

Role of Hedgehog Signaling in Ovarian Cancer

(2008) R. Bhattacharya et al.   CLINICAL CANCER RESEARCH

C2cd3 is required for cilia formation and Hedgehog signaling in mouse

(2008) A. N. Hoover et al.   DEVELOPMENT

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors

(2008) S. R. Parathath et al.   DEVELOPMENT

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4

(2008) Salvatore Cortellino et al.   DEVELOPMENTAL BIOLOGY

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

(2008) Mariana I. Capurro et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo

(2008) Hubert Kasperczyk et al.   FASEB JOURNAL

Msx2 Stimulates Chondrocyte Maturation by Controlling Ihh Expression

(2008) Katsuhiko Amano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cδ Negatively Regulates Hedgehog Signaling by Inhibition of Gli1 Activity

(2008) Qingsong Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting

(2008) Andrea Molckovsky et al.   Journal of Hematology & Oncology

Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase

(2008) Melanie Philipp et al.   MOLECULAR BIOLOGY OF THE CELL

Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

(2008) P.-L. So et al.   MOLECULAR CANCER THERAPEUTICS

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

(2008) Jason S. McLellan et al.   NATURE

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

(2008) Steven Hoseong Yang et al.   NATURE GENETICS

Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin–proteasome pathway

(2008) S Yue et al.   ONCOGENE

Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures

(2008) F Brellier et al.   ONCOGENE

The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like

(2008) L. A. Baena-Lopez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

(2008) Y. Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE

Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction

(2008) M. Evangelista et al.   Science Signaling

Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice

(2008) Karen Beckett et al.   TRENDS IN CELL BIOLOGY

Hedgehog signaling pathway: Development of antagonists for cancer therapy

(2008) Jingwu Xie   Current Oncology Reports