Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
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Title
Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
Authors
Keywords
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Journal
PLOS BIOLOGY
Volume 9, Issue 6, Pages e1001083
Publisher
Public Library of Science (PLoS)
Online
2011-06-18
DOI
10.1371/journal.pbio.1001083
References
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Related references
Note: Only part of the references are listed.- Genetic and biochemical definition of the Hedgehog receptor
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- G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
- (2010) Y. Chen et al. GENES & DEVELOPMENT
- The primary cilium: a signalling centre during vertebrate development
- (2010) Sarah C. Goetz et al. NATURE REVIEWS GENETICS
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
- (2009) M.-H. Chen et al. GENES & DEVELOPMENT
- Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules
- (2009) Hongbo Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
- (2009) Christopher W. Wilson et al. PLoS One
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
- (2009) Yu Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
- (2009) R. Rohatgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
- (2008) E. Dessaud et al. DEVELOPMENT
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- Hedgehog: functions and mechanisms
- (2008) M. Varjosalo et al. GENES & DEVELOPMENT
- Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase
- (2008) Melanie Philipp et al. MOLECULAR BIOLOGY OF THE CELL
- -Arrestin-Mediated Localization of Smoothened to the Primary Cilium
- (2008) J. J. Kovacs et al. SCIENCE
- Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
- (2008) M. Evangelista et al. Science Signaling
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