Regulation of Small GTPases by GEFs, GAPs, and GDIs

Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

(2012) Na Dong et al.   CELL

A Structure-Based Mechanism for Arf1-Dependent Recruitment of Coatomer to Membranes

(2012) Xinchao Yu et al.   CELL

The Sec7 Arf-GEF Is Recruited to the trans-Golgi Network by Positive Feedback

(2012) Brian C. Richardson et al.   DEVELOPMENTAL CELL

Activation of p115-RhoGEF Requires Direct Association of Gα13and the Dbl Homology Domain

(2012) Zhe Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Illuminating the functional and structural repertoire of human TBC/RABGAPs

(2012) Marieke A. M. Frasa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

(2012) K. Hanawa-Suetsugu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recessive Mutations in DOCK6, Encoding the Guanidine Nucleotide Exchange Factor DOCK6, Lead to Abnormal Actin Cytoskeleton Organization and Adams-Oliver Syndrome

(2011) Ranad Shaheen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gain-of-Function Mutations of ARHGAP31, a Cdc42/Rac1 GTPase Regulator, Cause Syndromic Cutis Aplasia and Limb Anomalies

(2011) Laura Southgate et al.   AMERICAN JOURNAL OF HUMAN GENETICS

High catalytic efficiency and resistance to denaturing in bacterial Rho GTPase-activating proteins

(2011) Yael Litvak et al.   BIOLOGICAL CHEMISTRY

Identification and characterisation of novel Mss4-binding Rab GTPases

(2011) Viktor Wixler et al.   BIOLOGICAL CHEMISTRY

TBC proteins: GAPs for mammalian small GTPase Rab?

(2011) Mitsunori Fukuda   BIOSCIENCE REPORTS

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation

(2011) Antonio Castro-Castro et al.   EMBO JOURNAL

Rho proteins of plants – Functional cycle and regulation of cytoskeletal dynamics

(2011) Elena Mucha et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif

(2011) Martin Primeau et al.   FEBS LETTERS

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

(2011) Francesca Lepri et al.   HUMAN MUTATION

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

(2011) Kiran Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DENN Domain Proteins: Regulators of Rab GTPases

(2011) Andrea L. Marat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RUTBC1 Protein, a Rab9A Effector That Activates GTP Hydrolysis by Rab32 and Rab33B Proteins

(2011) Ryan M. Nottingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Poliovirus Protein 3A Interactions with Viral and Cellular Proteins in Infected Cells

(2011) N. L. Teterina et al.   JOURNAL OF VIROLOGY

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

ARFGAP1 promotes AP-2-dependent endocytosis

(2011) Ming Bai et al.   NATURE CELL BIOLOGY

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

Chronicles of the GTPase switch

(2011) Jacqueline Cherfils et al.   Nature Chemical Biology

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recognition of the F&H motif by the Lowe syndrome protein OCRL

(2011) Michelle Pirruccello et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolutionary expansion of the Ras switch regulatory module in eukaryotes

(2011) Diego Díez et al.   NUCLEIC ACIDS RESEARCH

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain

(2011) Karla Langer et al.   PLoS One

The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability

(2011) Min Zong et al.   PLoS One

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

(2011) M. Mahankali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination

(2011) Y. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dual Binding Mode for RhoGTPases in Plexin Signalling

(2011) Christian H. Bell et al.   PLOS BIOLOGY

Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a

(2011) Wei Peng et al.   Protein & Cell

Secrets of a Successful Pathogen: Legionella Resistance to Progression Along the Autophagic Pathway

(2011) Amrita D. Joshi et al.   Frontiers in Microbiology

TBC1D24, an ARF6-Interacting Protein, Is Mutated in Familial Infantile Myoclonic Epilepsy

(2010) Antonio Falace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aarskog-Scott syndrome: Clinical update and report of nine novel mutations of theFGD1gene

(2010) A. Orrico et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

(2010) Shehab A. Ismail et al.   CELL

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

(2010) Lauren P. Jackson et al.   CELL

Microreview: Type IV secretion systems: versatility and diversity in function

(2010) Karin Wallden et al.   CELLULAR MICROBIOLOGY

Gαq allosterically activates and relieves autoinhibition of p63RhoGEF

(2010) Aruna Shankaranarayanan et al.   CELLULAR SIGNALLING

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Regulation of coat assembly—sorting things out at the ER

(2010) Elizabeth A Miller et al.   CURRENT OPINION IN CELL BIOLOGY

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

Manipulation of host membrane machinery by bacterial pathogens

(2010) Pascale Cossart et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p

(2010) Emi Mizuno-Yamasaki et al.   DEVELOPMENTAL CELL

Unravelling the mechanism of dual-specificity GAPs

(2010) Begoña Sot et al.   EMBO JOURNAL

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

(2010) Na Dong et al.   EMBO JOURNAL

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

(2010) Masako Koyama et al.   EMBO JOURNAL

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA

(2010) Stefan Schoebel et al.   EMBO REPORTS

Intersectin multidomain adaptor proteins: Regulation of functional diversity

(2010) Liudmyla Tsyba et al.   GENE

Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors

(2010) R. Bulgin et al.   INFECTION AND IMMUNITY

The ADP-Ribosylation Domain of Pseudomonas aeruginosa ExoS Is Required for Membrane Bleb Niche Formation and Bacterial Survival within Epithelial Cells

(2010) A. A. Angus et al.   INFECTION AND IMMUNITY

Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

(2010) Zhe Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure ofShigellaIpgB2 in Complex with Human RhoA

(2010) Björn U. Klink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5·Vps9 System

(2010) Tamami Uejima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scaffold Proteins IRSp53 and Spinophilin Regulate Localized Rac Activation by T-lymphocyte Invasion and Metastasis Protein 1 (TIAM1)

(2010) Soumitra Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion

(2010) Athanassios Dovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of a Novel Cdc42 Binding Module of Bem1 and Its Interaction with Ste20 and Cdc42

(2010) Tomoyuki Takaku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Studies of the Arf Activator Arno on Model Membranes in the Presence of Arf Effectors Suggest Control by a Positive Feedback Loop

(2010) Danièle Stalder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatio-temporal Rho GTPase signaling - where are we now?

(2010) O. Pertz   JOURNAL OF CELL SCIENCE

SAXS and X-ray Crystallography Suggest an Unfolding Model for the GDP/GTP Conformational Switch of the Small GTPase Arf6

(2010) Valérie Biou et al.   JOURNAL OF MOLECULAR BIOLOGY

The 1.9Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones

(2010) Fangming Wu et al.   JOURNAL OF STRUCTURAL BIOLOGY

RhoA Phosphorylation Induces Rac1 Release from Guanine Dissociation Inhibitor   and Stimulation of Vascular Smooth Muscle Cell Migration

(2010) M. Rolli-Derkinderen et al.   MOLECULAR AND CELLULAR BIOLOGY

The BNIP-2 and Cdc42GAP Homology (BCH) Domain of p50RhoGAP/Cdc42GAP Sequesters RhoA from Inactivation by the Adjacent GTPase-activating Protein Domain

(2010) Yi Ting Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

(2010) Andrey S. Selyunin et al.   NATURE

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability

(2010) Cheryl Shoubridge et al.   NATURE GENETICS

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

TRAPP complexes in membrane traffic: convergence through a common Rab

(2010) Jemima Barrowman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin

(2010) K. Farid Ahmad et al.   PLoS One

Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

(2010) F. Chianale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

(2010) Jodi Gureasko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA

(2010) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin  1

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3-DH domain linker

(2010) Carsten Kintscher et al.   PROTEIN SCIENCE

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reaction

(2009) Christoph Thomas et al.   BIOLOGICAL CHEMISTRY

The Salmonella Effector SptP Dephosphorylates Host AAA+ ATPase VCP to Promote Development of its Intracellular Replicative Niche

(2009) Daniel Humphreys et al.   Cell Host & Microbe

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

Noonan syndrome and neurofibromatosis type I in a family with a novel mutation inNF1

(2009) AM Nyström et al.   CLINICAL GENETICS

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

(2009) William E Tidyman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA

(2009) Hye-Young Suh et al.   EMBO JOURNAL

The COPI system: Molecular mechanisms and function

(2009) R. Beck et al.   FEBS LETTERS

Amphipathic helices and membrane curvature

(2009) Guillaume Drin et al.   FEBS LETTERS

Importin-β Is a GDP-to-GTP Exchange Factor of Ran

(2009) Thierry G. Lonhienne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the GTPase-activating Protein-related Domain from IQGAP1

(2009) Vinodh B. Kurella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ran on tracks - cytoplasmic roles for a nuclear regulator

(2009) D. Yudin et al.   JOURNAL OF CELL SCIENCE

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

(2009) S. Kupzig et al.   MOLECULAR AND CELLULAR BIOLOGY

RabGDI Displacement by DrrA from Legionella Is a Consequence of Its Guanine Nucleotide Exchange Activity

(2009) Stefan Schoebel et al.   MOLECULAR CELL

The evolving understanding of COPI vesicle formation

(2009) Victor W. Hsu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

(2009) Zhiwei Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations inSYNGAP1in Autosomal Nonsyndromic Mental Retardation

(2009) Fadi F. Hamdan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

(2009) H. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway

(2009) F. E. Rivera-Molina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA

(2009) Tomasz Cierpicki et al.   PROTEIN SCIENCE

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

(2009) J. Yang et al.   SCIENCE

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

(2009) Vytas A. Bankaitis et al.   TRENDS IN BIOCHEMICAL SCIENCES

The guanine-nucleotide-exchange factor BopE fromBurkholderia pseudomalleiadopts a compact version of theSalmonellaSopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42

(2008) Abhishek Upadhyay et al.   BIOCHEMICAL JOURNAL

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

(2008) Alexander Eberth et al.   BIOCHEMICAL JOURNAL

Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins†

(2008) Marielle E. Yohe et al.   BIOCHEMISTRY

The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes

(2008) Yiying Cai et al.   CELL

Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation

(2008) Maikke B. Ohlson et al.   Cell Host & Microbe

Symmetry-Breaking Polarization Driven by a Cdc42p GEF-PAK Complex

(2008) Lukasz Kozubowski et al.   CURRENT BIOLOGY

The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

(2008) Andrea Scrima et al.   EMBO JOURNAL

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

(2008) Jonathan Rapley et al.   EMBO REPORTS

A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor

(2008) Yi Deng et al.   EMBO REPORTS

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

(2008) Vladimir Pena et al.   EMBO REPORTS

Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

(2008) Stefan Veltel et al.   FEBS LETTERS

A Structural Model of the GDP Dissociation Inhibitor Rab Membrane Extraction Mechanism

(2008) Alexander Ignatev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RanBP10 Is a Cytoplasmic Guanine Nucleotide Exchange Factor That Modulates Noncentrosomal Microtubules

(2008) Harald Schulze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity in Ras and Rap Signaling

(2008) Judith H. Raaijmakers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of Arf GTPase-activating Protein Activity by the BAR Domain in ASAP1

(2008) Xiaoying Jian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consensus nomenclature for the human ArfGAP domain-containing proteins

(2008) Richard A. Kahn et al.   JOURNAL OF CELL BIOLOGY

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

(2008) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

(2008) Pilong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

(2008) Stefan Veltel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First crystallographic models of human TBC domains in the context of a family-wide structural analysis

(2008) Wolfram Tempel et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Asymmetric Tethering of Flat and Curved Lipid Membranes by a Golgin

(2008) G. Drin et al.   SCIENCE