Mechanisms Regulating Protein Localization

Nuclear pore proteins and the control of genome functions

(2015) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease

(2014) Elizabeth J. Tran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Going against the flow: A case for peroxisomal protein export

(2014) Chris Williams   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Embracing the void—how much do we really know about targeting and translocation to the endoplasmic reticulum?

(2014) Naama Aviram et al.   CURRENT OPINION IN CELL BIOLOGY

Transportin-1 and Transportin-2: Protein nuclear import and beyond

(2014) Laure Twyffels et al.   FEBS LETTERS

Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway

(2014) Eric H. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin 8 Regulates the Transport of Mature MicroRNAs into the Cell Nucleus

(2014) Yao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap 2 in Hedgehog signaling

(2014) Q. Shi et al.   JOURNAL OF CELL SCIENCE

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Atomic basis of CRM1-cargo recognition, release and inhibition

(2014) Ho Yee Joyce Fung et al.   SEMINARS IN CANCER BIOLOGY

Biological Significance of the Importin-β Family-Dependent Nucleocytoplasmic Transport Pathways

(2014) Makoto Kimura et al.   TRAFFIC

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vesicle-mediated export from the ER: COPII coat function and regulation

(2013) Jennifer G. D'Arcangelo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Co-translational targeting and translocation of proteins to the endoplasmic reticulum

(2013) Yvonne Nyathi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Take the (RN)A-train: Localization of mRNA to the endoplasmic reticulum

(2013) Orit Hermesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation

(2013) Jian Qiu et al.   CELL

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

Structure and evolutionary origins of the CMG complex

(2013) Silvia Onesti et al.   CHROMOSOMA

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal

(2013) T. Maiuri et al.   HUMAN MOLECULAR GENETICS

Cytochromes P450: Roles in Diseases

(2013) Irina A. Pikuleva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tangled Circuitry of Metabolism and Apoptosis

(2013) Joshua L. Andersen et al.   MOLECULAR CELL

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

(2013) J. Zhuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Nucleoid: Integrating Mitochondrial DNA into Cellular Homeostasis

(2013) R. Gilkerson et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Import of proteins into the peroxisomal matrix

(2013) Sohel Hasan et al.   Frontiers in Physiology

The ERMES complex and ER–mitochondria connections

(2012) Agnès H. Michel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The mitochondrial protein import machinery has multiple connections to the respiratory chain

(2012) Bogusz Kulawiak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria

(2012) Diana Stojanovski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of mitochondrial carrier proteins: Molecular mechanisms of import into mitochondria

(2012) Alessandra Ferramosca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The chloroplast protein import system: From algae to trees

(2012) Lan-Xin Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Finding the will and the way of ERAD substrate retrotranslocation

(2012) Randolph Y Hampton et al.   CURRENT OPINION IN CELL BIOLOGY

Microtubules Regulate Hypoxia-inducible Factor-1α Protein Trafficking and Activity

(2012) Marisa Carbonaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of a Unique Interface between Carbohydrate Response Element-binding Protein (ChREBP) and 14-3-3β Protein

(2012) Qiang Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

(2012) S. De et al.   JOURNAL OF CELL SCIENCE

Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore

(2012) M. Kumeta et al.   JOURNAL OF CELL SCIENCE

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

Microtubule-severing enzymes at the cutting edge

(2012) D. J. Sharp et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner

(2012) A. Asada et al.   JOURNAL OF CELL SCIENCE

Parathyroid Hormone-Related Protein: An Update

(2012) John J. Wysolmerski   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sequence and structural analyses of nuclear export signals in the NESdb database

(2012) Darui Xu et al.   MOLECULAR BIOLOGY OF THE CELL

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

The transport of integral membrane proteins across the nuclear pore complex

(2012) Anne C. Meinema et al.   Nucleus

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

Structural elements of the mitochondrial preprotein-conducting channel Tom40 dissolved by bioinformatics and mass spectrometry

(2011) Dennis Gessmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

(2011) Yanyan Zhang et al.   CELL RESEARCH

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Mechanism of Microtubule-facilitated “Fast Track” Nuclear Import

(2011) Daniela Martino Roth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Disulfide Relay: Redox-regulated Protein Import into the Intermembrane Space

(2011) Johannes M. Herrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional evolution of nuclear structure

(2011) Katherine L. Wilson et al.   JOURNAL OF CELL BIOLOGY

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Induction of Ran GTP drives ciliogenesis

(2011) Shuling Fan et al.   MOLECULAR BIOLOGY OF THE CELL

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae

(2011) N. Gadir et al.   RNA

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

Oxidation-driven protein import into mitochondria: Insights and blind spots

(2010) Jan Riemer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular basis for specificity of nuclear import and prediction of nuclear localization

(2010) Mary Marfori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational myristoylation: Fat matters in cellular life and death

(2010) Dale D.O. Martin et al.   BIOCHIMIE

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Recognition of nuclear targeting signals by Karyopherin-β proteins

(2010) Darui Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MST1 Promotes Apoptosis through Phosphorylation of Histone H2AX

(2010) Weihong Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-Dose Gamma-Ray Irradiation Induces Translocation of Nrf2 Into Nuclear in Mouse Macrophage RAW264.7 Cells

(2010) Mitsutoshi TSUKIMOTO et al.   JOURNAL OF RADIATION RESEARCH

P53 is transported into the nucleus via an Hsf1-dependent nuclear localization mechanism

(2010) Qiang Li et al.   MOLECULAR CARCINOGENESIS

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

(2009) Lasse Weinmann et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Small Ubiquitin-Like Modifier-2 Modification of Retinoic Acid Receptor-α Regulates Its Subcellular Localization and Transcriptional Activity

(2009) Li Zhu et al.   ENDOCRINOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Androgen Receptor Phosphorylation and Activity Are Regulated by an Association with Protein Phosphatase 1

(2009) Shaoyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin-driven Nuclear Entry: Trigger for Sex Determination and Terminal Differentiation

(2009) John A. Hanover et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors

(2009) Cristina Gontan et al.   JOURNAL OF CELL BIOLOGY

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

(2009) Dionisia P. Sideris et al.   JOURNAL OF CELL BIOLOGY

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization

(2009) T. Dietschy et al.   JOURNAL OF CELL SCIENCE

The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus

(2009) Eldar Zehorai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

(2009) Dusanka Milenkovic et al.   MOLECULAR BIOLOGY OF THE CELL

PeroxisomeDB 2.0: an integrative view of the global peroxisomal metabolome

(2009) Agatha Schlüter et al.   NUCLEIC ACIDS RESEARCH

Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells

(2009) E Komlodi-Pasztor et al.   ONCOGENE

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae

(2009) G. Zipor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

(2009) Cynthia K. Shrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importins and Beyond: Non-Conventional Nuclear Transport Mechanisms

(2009) Kylie M. Wagstaff et al.   TRAFFIC

Expanding the Definition of the Classical Bipartite Nuclear Localization Signal

(2009) Allison Lange et al.   TRAFFIC

DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae

(2008) Lori A. Rowe et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)

(2008) Haruhiko Sakiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Activates ChREBP by Increasing Its Rate of Nuclear Entry and Relieving Repression of Its Transcriptional Activity

(2008) Michael N. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Roles of c-Abl and Cdk5 in Regulation of p53 in Response to Oxidative Stress

(2008) Jong-Hee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5

(2008) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Yeast Ace2 Transcription Factor during the Cell Cycle

(2008) Mohammed Sbia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY

Evolutionary and Transcriptional Analysis of Karyopherin β Superfamily Proteins

(2008) Yu Quan et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification and Characterization of a General Nuclear Translocation Signal in Signaling Proteins

(2008) Dana Chuderland et al.   MOLECULAR CELL