The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo

(2013) Jiefang Guo et al.   CANCER LETTERS

Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer

(2013) S. B. Keysar et al.   CANCER RESEARCH

Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

(2013) M. Malatesta et al.   CANCER RESEARCH

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

Activation of the Transcription Factor GLI1 by WNT Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration

(2013) Ikuo Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

(2013) Lisa D. Mills et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the Glioma-Associated Oncogene Homolog 1 (Gli1) in Advanced Serous Ovarian Cancer Is Associated with Unfavorable Overall Survival

(2013) Alessandra Ciucci et al.   PLoS One

Gli1 Mediates Lung Cancer Cell Proliferation and Sonic Hedgehog-Dependent Mesenchymal Cell Activation

(2013) Olga Bermudez et al.   PLoS One

Abstract 5336: Macrophage migration inhibitory factor (MIF) plays roles in proliferation, survival and migration of Ewing tumor cells through the activation of several tyrosine kinases

(2012) Hyung Gyoo Kang et al.   CANCER RESEARCH

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3

(2012) Ian M. Love et al.   CELL CYCLE

Activation of the Sonic Hedgehog Pathway and Its Prognostic Impact in Patients with Gastric Cancer

(2012) Zenichiro Saze et al.   DIGESTIVE SURGERY

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

Crosstalk between TGF-β and hedgehog signaling in cancer

(2012) Delphine Javelaud et al.   FEBS LETTERS

Post-translational regulation of TGF-β receptor and Smad signaling

(2012) Pinglong Xu et al.   FEBS LETTERS

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

(2012) Andrea E. Lo Ré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide mechanisms of Smad binding

(2012) M Morikawa et al.   ONCOGENE

The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

(2012) Xin Zheng et al.   PLoS One

Dynamics of TGF-  signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4

(2012) A. Warmflash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

(2012) M. Rajurkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Sonic hedgehog pathway expression in non-small cell lung cancer

(2012) Malvi Savani et al.   Therapeutic Advances in Medical Oncology

Targeted Expression of GLI1 in the Salivary Glands Results in an Altered Differentiation Program and Hyperplasia

(2011) Marie Fiaschi et al.   AMERICAN JOURNAL OF PATHOLOGY

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

(2011) Z I Thomas et al.   BRITISH JOURNAL OF CANCER

GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells

(2011) S. Joost et al.   CANCER RESEARCH

TGF- /SMAD/GLI2 Signaling Axis in Cancer Progression and Metastasis

(2011) D. Javelaud et al.   CANCER RESEARCH

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

Cyclopamine Blocked the Growth of Colorectal Cancer SW116 Cells by Modulating Some Target Genes of Gli1 in vitro

(2011) Jian-Ye Wu et al.   HEPATO-GASTROENTEROLOGY

GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment

(2011) Sherine F. Elsawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS

(2010) Matthias Lauth et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

(2010) B. Stecca et al.   Journal of Molecular Cell Biology

Development of Mammary Tumors by Conditional Expression of GLI1

(2009) M. Fiaschi et al.   CANCER RESEARCH

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE