Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Authors
Keywords
-
Journal
Cancers
Volume 8, Issue 2, Pages 22
Publisher
MDPI AG
Online
2016-02-15
DOI
10.3390/cancers8020022
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A phase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT).
- (2017) Martin Schlumberger et al. JOURNAL OF CLINICAL ONCOLOGY
- Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target
- (2016) Jiancheng Zhou et al. CANCER LETTERS
- Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
- (2015) Hayley J. Sharpe et al. CANCER CELL
- p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9
- (2015) Joon Won Yoon et al. DNA REPAIR
- MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor
- (2015) Lucile Hoch et al. FASEB JOURNAL
- SOX9 inhibits -TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties
- (2015) W. Deng et al. JOURNAL OF CELL SCIENCE
- Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
- (2015) Daniel V.T. Catenacci et al. JOURNAL OF CLINICAL ONCOLOGY
- GLI2 inhibition abrogates human leukemia stem cell dormancy
- (2015) Anil Sadarangani et al. Journal of Translational Medicine
- Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells
- (2015) Armine Matevossian et al. Molecular Cancer
- The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis
- (2015) Richard L. Carpenter et al. Oncotarget
- Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer
- (2015) Lixin Zhang et al. NEOPLASIA
- GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
- (2015) Ritesh K. Srivastava et al. Oncotarget
- The potential of heparanase as a therapeutic target in cancer
- (2014) Claudio Pisano et al. BIOCHEMICAL PHARMACOLOGY
- Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells
- (2014) C D’Amato et al. BRITISH JOURNAL OF CANCER
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Abstract LB-380: Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the Smoothened inhibitor IPI-926
- (2014) V. T. Campbell et al. CANCER RESEARCH
- Abstract LB-284: The novel therapeutic monoclonal antibody VGX-100 neutralises VEGF-C and inhibits tumor growth and metastasis in subcutaneous and orthotopic models of human cancer.
- (2014) M. E. Baldwin et al. CANCER RESEARCH
- Bevacizumab: A Review of Its Use in Advanced Cancer
- (2014) Gillian M. Keating DRUGS
- Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumorsin vitroandin vivoby targeting overexpressed Gli1
- (2014) Kornelius Kerl et al. INTERNATIONAL JOURNAL OF CANCER
- The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner
- (2014) Monica D. Nye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hedgehog pathway as a potential treatment target in human cholangiocarcinoma
- (2014) Dorothee Riedlinger et al. Journal of Hepato-Biliary-Pancreatic Sciences
- Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
- (2014) Edward B Garon et al. LANCET
- Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial
- (2014) Marcia S Brose et al. LANCET
- Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
- (2014) Hansjochen Wilke et al. LANCET ONCOLOGY
- Sonic hedgehog–Gli1 signals promote epithelial–mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway
- (2014) Zhang Ke et al. MEDICAL ONCOLOGY
- Abstract B279: A phase I study determining the safety and tolerability of combination therapy with Pazopanib (P), a VEGFR/PDGFR/Raf inhibitor, and GSK1120212 (Trametinib: T), a MEK inhibitor, in advanced solid tumors with expansion cohorts in advanced differentiated thyroid cancer (DTC), cholangiocarcinoma (ChCA), and soft tissue sarcoma (STS).
- (2014) N. Azad et al. MOLECULAR CANCER THERAPEUTICS
- Darinaparsin Inhibits Prostate Tumor-Initiating Cells and Du145 Xenografts and Is an Inhibitor of Hedgehog Signaling
- (2014) N. Bansal et al. MOLECULAR CANCER THERAPEUTICS
- Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
- (2014) Sabrina Pricl et al. Molecular Oncology
- Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
- (2014) E Petrova et al. ONCOGENE
- Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin β4-Mediated FAK Signaling
- (2014) Qi Chen et al. PLoS One
- Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells
- (2014) Mehdi Hayat Shahi et al. PLoS One
- Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
- (2014) Fritz Aberger et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence
- (2014) Chun-Jen Liu WORLD JOURNAL OF GASTROENTEROLOGY
- Arsenic Trioxide Inhibits the Hedgehog Pathway Which Is Aberrantly Activated in Acute Promyelocytic Leukemia
- (2013) Dongguang Yang et al. ACTA HAEMATOLOGICA
- Antibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas
- (2013) A V Salnikov et al. BRITISH JOURNAL OF CANCER
- Smoothened Inhibition Leads to Decreased Proliferation and Induces Apoptosis in Esophageal Adenocarcinoma Cells
- (2013) Ali H. Zaidi et al. CANCER INVESTIGATION
- The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth
- (2013) Hu Zhu et al. CANCER LETTERS
- A Novel Model for Evaluating Therapies Targeting Human Tumor Vasculature and Human Cancer Stem-like Cells
- (2013) D. Burgos-Ojeda et al. CANCER RESEARCH
- Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant
- (2013) Tsuyoshi Ishii et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling
- (2013) Naokazu Ibuki et al. INTERNATIONAL JOURNAL OF CANCER
- Cabozantinib in Progressive Medullary Thyroid Cancer
- (2013) Rossella Elisei et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro
- (2013) Min You et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
- (2013) K. T. Ostapoff et al. MOLECULAR CANCER THERAPEUTICS
- Structure of the human smoothened receptor bound to an antitumour agent
- (2013) Chong Wang et al. NATURE
- Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
- (2013) Elissaveta Petrova et al. Nature Chemical Biology
- NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200
- (2013) J. Fu et al. NEURO-ONCOLOGY
- Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation
- (2013) Shunsuke Nakamura et al. PLoS One
- Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli
- (2013) Jin-bin Han et al. OncoTargets and Therapy
- Axitinib for the Management of Metastatic Renal Cell Carcinoma
- (2013) Bernard Escudier et al. Drugs in research & development
- The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward
- (2013) M. W. Kieran et al. Cold Spring Harbor Perspectives in Medicine
- NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128
- (2013) R Nanta et al. Oncogenesis
- Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
- (2012) Tomohiro Ohashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Abstract 2819: Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling
- (2012) Mark H. Bender et al. CANCER RESEARCH
- Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target
- (2012) B. Sitohy et al. CANCER RESEARCH
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice
- (2012) K. Inoue et al. CLINICAL CANCER RESEARCH
- Sunitinib targets PDGF-receptor and Flt3 and reduces survival and migration of human meningioma cells
- (2012) Nadine Andrae et al. EUROPEAN JOURNAL OF CANCER
- Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin
- (2012) Eri Makinodan et al. EXPERIMENTAL DERMATOLOGY
- Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo
- (2012) Malin Wickström et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
- (2012) Qing Chang et al. INTERNATIONAL JOURNAL OF CANCER
- Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen
- (2012) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis
- (2012) Vito Ferro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
- (2012) Winette TA van der Graaf et al. LANCET
- Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial
- (2012) George D Demetri et al. LANCET
- Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
- (2012) Axel Grothey et al. LANCET
- Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development
- (2012) S. B. Gendreau et al. MOLECULAR CANCER THERAPEUTICS
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
- (2012) M. Rajurkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
- (2011) C. Metcalfe et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
- (2011) T. Tang et al. CLINICAL CANCER RESEARCH
- Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial
- (2011) Samuel A. Wells et al. JOURNAL OF CLINICAL ONCOLOGY
- Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood-Brain Barrier
- (2011) A. Rohner et al. MOLECULAR CANCER THERAPEUTICS
- Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth
- (2011) F. M. Yakes et al. MOLECULAR CANCER THERAPEUTICS
- Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
- (2011) X Cao et al. ONCOGENE
- Once on 'Fast Track,' Avastin Now Derailed
- (2011) J. Couzin-Frankel et al. SCIENCE
- Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
- (2011) Michael J. Munchhof et al. ACS Medicinal Chemistry Letters
- Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling
- (2011) Qipeng Fan et al. Chinese Journal of Cancer
- Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
- (2010) Scott M. Wilhelm et al. INTERNATIONAL JOURNAL OF CANCER
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
- (2010) Cora N. Sternberg et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma
- (2010) Zeshaan A. Rasheed et al. JNCI-Journal of the National Cancer Institute
- Smoothened as a new therapeutic target for human osteosarcoma
- (2010) Masataka Hirotsu et al. Molecular Cancer
- Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells
- (2010) M. Mimeault et al. MOLECULAR CANCER THERAPEUTICS
- Molecular Therapy Targeting Sonic Hedgehog and Hepatocyte Growth Factor Signaling in a Mouse Model of Medulloblastoma
- (2010) V. Coon et al. MOLECULAR CANCER THERAPEUTICS
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
- (2010) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
- (2010) B. Stecca et al. Journal of Molecular Cell Biology
- Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
- (2010) Shifeng Pan et al. ACS Medicinal Chemistry Letters
- GDC-0449—A potent inhibitor of the hedgehog pathway
- (2009) Kirk D. Robarge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion
- (2009) H.-W. Lo et al. CANCER RESEARCH
- A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
- (2009) Barbara Stecca et al. EMBO JOURNAL
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
- (2009) Robert J. Motzer et al. JOURNAL OF CLINICAL ONCOLOGY
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
- (2009) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
- (2009) Motoko Seto et al. MOLECULAR CARCINOGENESIS
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
- (2009) Chen Zhao et al. NATURE
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
- (2009) Christopher W. Wilson et al. PLoS One
- Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
- (2009) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer
- (2008) Srinivas K. Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and anticancer activity studies of cyclopamine derivatives
- (2008) Jianjun Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Targeting CD24 for Treatment of Colorectal and Pancreatic Cancer by Monoclonal Antibodies or Small Interfering RNA
- (2008) E. Sagiv et al. CANCER RESEARCH
- Hedgehog: functions and mechanisms
- (2008) M. Varjosalo et al. GENES & DEVELOPMENT
- Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog
- (2008) John A. Buglino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
- (2008) Scott M. Wilhelm et al. MOLECULAR CANCER THERAPEUTICS
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation