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NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

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(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

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(2010) Matthias Lauth et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

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A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

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Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling

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Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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(2009) Baozhi Chen et al.   Nature Chemical Biology

Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

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