Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

(2011) Grace Ying Wang et al.   CANCER CELL

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

(2011) Marina Grachtchouk et al.   JOURNAL OF CLINICAL INVESTIGATION

Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor

(2011) Hans Skvara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wounding mobilizes hair follicle stem cells to form tumors

(2011) S. Y. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes

(2011) M. Kasper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

(2010) B. Stecca et al.   Journal of Molecular Cell Biology

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer

(2009) Maria–Theresa Mueller et al.   GASTROENTEROLOGY

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Cloning of the HumanGLI2Promoter

(2009) Sylviane Dennler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes

(2009) S Laner-Plamberger et al.   ONCOGENE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

(2008) Helene R. McMurray et al.   NATURE

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

Gli2 Is a Novel Regulator of Sox2 Expression in Telencephalic Neuroepithelial Cells

(2008) Hiromi Takanaga et al.   STEM CELLS