HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth

A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53

(2015) Shi Qiu et al.   CANCER LETTERS

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

(2015) Silvia Pandolfi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy

(2014) Min Lu et al.   FEBS LETTERS

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

Nuclear iASPP may facilitate prostate cancer progression

(2014) E V Morris et al.   Cell Death & Disease

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP

(2013) Min Lu et al.   CANCER CELL

Elevated expression of iASPP correlates with poor prognosis and chemoresistance/radioresistance in FIGO Ib1-IIa squamous cell cervical cancer

(2013) Liping Cao et al.   CELL AND TISSUE RESEARCH

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

Reactivation of p53 as therapeutic intervention for malignant melanoma

(2013) Aart G. Jochemsen   CURRENT OPINION IN ONCOLOGY

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

(2013) Luis A. Milla et al.   INTERNATIONAL JOURNAL OF CANCER

NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

(2013) Ahmad Jalili et al.   PLoS One

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

(2012) Bobby Bhatia et al.   ACTA NEUROPATHOLOGICA

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance

(2012) Zhengzheng Liu et al.   MEDICAL ONCOLOGY

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

(2012) S Pandolfi et al.   ONCOGENE

Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo

(2012) Junfang Wu et al.   PLoS One

HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells

(2012) Roberta Santini et al.   STEM CELLS

iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway

(2011) Jinfeng Chen et al.   BMC CANCER

E2F1-dependent oncogenic addiction of melanoma cells to MDM2

(2011) M Verhaegen et al.   ONCOGENE

Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma

(2010) B Bhatia et al.   ONCOGENE

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

E2F1 in Melanoma Progression and Metastasis

(2009) Vijay Alla et al.   JNCI-Journal of the National Cancer Institute

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

(2008) Y. Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA