Fibroblast growth factor signalling in osteoarthritis and cartilage repair
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Fibroblast growth factor signalling in osteoarthritis and cartilage repair
Authors
Keywords
-
Journal
Nature Reviews Rheumatology
Volume 16, Issue 10, Pages 547-564
Publisher
Springer Science and Business Media LLC
Online
2020-08-17
DOI
10.1038/s41584-020-0469-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
- (2020) Lingfeng Chen et al. Nature Chemical Biology
- Fibroblast Growth Factor 10 and Vertebrate Limb Development
- (2019) Libo Jin et al. Frontiers in Genetics
- Structural Biology of the FGF7 Subfamily
- (2019) Allen Zinkle et al. Frontiers in Genetics
- Osteoarthritis
- (2019) David J Hunter et al. LANCET
- Mechanisms of synovial joint and articular cartilage development
- (2019) Ryota Chijimatsu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 ( Fgf18 )
- (2019) Andrew S. Hagan et al. DEVELOPMENTAL DYNAMICS
- Surgical and tissue engineering strategies for articular cartilage and meniscus repair
- (2019) Heenam Kwon et al. Nature Reviews Rheumatology
- FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice
- (2019) Liang Kuang et al. ANNALS OF THE RHEUMATIC DISEASES
- Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis
- (2019) Marc C. Hochberg et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull
- (2018) Linnea Schmidt et al. Disease Models & Mechanisms
- New insights into the natural course of knee osteoarthritis: early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study
- (2018) K. Kisand et al. OSTEOARTHRITIS AND CARTILAGE
- Crk proteins transduce FGF signaling to promote lens fiber cell elongation
- (2018) Tamica N Collins et al. eLife
- Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection
- (2018) Patience M. Burt et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Sprifermin treatment enhances cartilage integration in an in vitro repair model
- (2018) Mackenzie L. Sennett et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
- (2018) Gaozhi Chen et al. NATURE
- A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice
- (2018) Q. Tan et al. OSTEOARTHRITIS AND CARTILAGE
- Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission
- (2018) Xudong Yao et al. PHARMACOLOGICAL RESEARCH
- Integration capacity of human iPS cell-derived cartilage
- (2018) Xike Chen et al. TISSUE ENGINEERING PART A
- A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome
- (2017) Lingyun Tang et al. HUMAN MOLECULAR GENETICS
- FGF9 mutation causes craniosynostosis along with multiple synostoses
- (2017) Maria Rodriguez-Zabala et al. HUMAN MUTATION
- The role of metabolism in the pathogenesis of osteoarthritis
- (2017) Ali Mobasheri et al. Nature Reviews Rheumatology
- Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix
- (2017) A. Gigout et al. OSTEOARTHRITIS AND CARTILAGE
- Knee osteoarthritis has doubled in prevalence since the mid-20th century
- (2017) Ian J. Wallace et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization
- (2017) Yang Liu et al. STRUCTURE
- Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability
- (2017) Zhifeng Huang et al. Cell Reports
- Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis
- (2017) Abdellatif El-Seoudi et al. Journal of Cell Communication and Signaling
- FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth
- (2016) Kannan Karuppaiah et al. DEVELOPMENT
- Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL)
- (2016) Taeju Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis
- (2016) Jason S. Rockel et al. JOURNAL OF CLINICAL INVESTIGATION
- Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ
- (2016) Zhifeng Huang et al. MOLECULAR CELL
- Ageing and the pathogenesis of osteoarthritis
- (2016) Richard F. Loeser et al. Nature Reviews Rheumatology
- Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis
- (2016) S. Zhou et al. OSTEOARTHRITIS AND CARTILAGE
- Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner
- (2016) A. Bianchi et al. OSTEOARTHRITIS AND CARTILAGE
- Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis
- (2016) Xiaoqian Ye et al. PLASTIC AND RECONSTRUCTIVE SURGERY
- Mechanism of FGF receptor dimerization and activation
- (2016) Sarvenaz Sarabipour et al. Nature Communications
- Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice
- (2016) Siru Zhou et al. Scientific Reports
- Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice
- (2016) Junzhou Tang et al. Arthritis & Rheumatology
- Osteoarthritis
- (2016) Johanne Martel-Pelletier et al. Nature Reviews Disease Primers
- A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis
- (2016) Wei Xu et al. Scientific Reports
- Dynamics and Membrane Interactions of Protein Kinase C
- (2015) Tatyana I. Igumenova BIOCHEMISTRY
- State of the evidence
- (2015) Kelli D. Allen et al. CURRENT OPINION IN RHEUMATOLOGY
- Fibroblast growth factor signaling in skeletal development and disease
- (2015) David M. Ornitz et al. GENES & DEVELOPMENT
- Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis
- (2015) R. Li et al. GENETICS AND MOLECULAR RESEARCH
- Advances in treatment of achondroplasia and osteoarthritis
- (2015) Kendra A. Klag et al. HUMAN MOLECULAR GENETICS
- FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation
- (2015) Matthew R. Karolak et al. HUMAN MOLECULAR GENETICS
- PI3K and AKT: Unfaithful Partners in Cancer
- (2015) Seraina Faes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- FGFR3 Unliganded Dimer Stabilization by the Juxtamembrane Domain
- (2015) Sarvenaz Sarabipour et al. JOURNAL OF MOLECULAR BIOLOGY
- Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model
- (2015) Daniel Howard et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Osteoarthritis
- (2015) S Glyn-Jones et al. LANCET
- Effects of FGF-2 and FGF receptor antagonists on MMP enzymes, aggrecan, and type II collagen in primary human OA chondrocytes
- (2015) E Nummenmaa et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- The Fibroblast Growth Factor signaling pathway
- (2015) David M. Ornitz et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location-Independent Post Hoc Analysis Using Magnetic Resonance Imaging
- (2015) Felix Eckstein et al. Arthritis & Rheumatology
- Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy
- (2015) Nobuyuki Itoh et al. Frontiers in Endocrinology
- Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention
- (2015) Moti L. Tiku et al. Therapeutic Advances in Musculoskeletal Disease
- A new missense mutation in FGF23 gene in a male with hyperostosis–hyperphosphatemia syndrome (HHS)
- (2014) Farzaneh Abbasi et al. GENE
- FGFR3 mutation causes abnormal membranous ossification in achondroplasia
- (2014) Federico Di Rocco et al. HUMAN MOLECULAR GENETICS
- Identification of Fibroblast Growth Factor-18 as a Molecule to Protect Adult Articular Cartilage by Gene Expression Profiling
- (2014) Yoshifumi Mori et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RECENT RESEARCH ON THE GROWTH PLATE: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration
- (2014) R. Chung et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- The effect of recombinant human fibroblast growth factor-18 on articular cartilage following single impact load
- (2014) Lynne Barr et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model
- (2014) Jonathon Power et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Emerging regulators of the inflammatory process in osteoarthritis
- (2014) Ru Liu-Bryan et al. Nature Reviews Rheumatology
- Fibroblast growth factor-21 concentration in serum and synovial fluid is associated with radiographic bone loss of knee osteoarthritis
- (2014) Zhan-Chun Li et al. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
- Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2014) L. Stefan Lohmander et al. Arthritis & Rheumatology
- Synovial Joints: from Development to Homeostasis
- (2014) Lara Longobardi et al. Current Osteoporosis Reports
- Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo
- (2013) Ka-Wing Chong et al. ARTHRITIS AND RHEUMATISM
- Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes
- (2013) Nicole Hajicek et al. BIOCHEMISTRY
- Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis
- (2013) Lucia Grillo et al. GENE
- Exploring mechanisms of FGF signalling through the lens of structural biology
- (2013) Regina Goetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Functional articular cartilage repair: here, near, or is the best approach not yet clear?
- (2013) Simon C. Mastbergen et al. Nature Reviews Rheumatology
- Essential roles of Crk and CrkL in fibroblast structure and motility
- (2013) T-J Park et al. ONCOGENE
- Development of the Endochondral Skeleton
- (2013) F. Long et al. Cold Spring Harbor Perspectives in Biology
- Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology
- (2013) A. A. Belov et al. Cold Spring Harbor Perspectives in Biology
- Applications of Stem Cell Therapy for Physeal Injuries.
- (2013) Anita Sanghani et al. Current Stem Cell Research & Therapy
- Bent Bone Dysplasia-FGFR2 type, a Distinct Skeletal Disorder, Has Deficient Canonical FGF Signaling
- (2012) Amy E. Merrill et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice
- (2012) Tujun Weng et al. ARTHRITIS AND RHEUMATISM
- The effect of co-culturing costal chondrocytes and dental pulp stem cells combined with exogenous FGF9 protein on chondrogenesis and ossification in engineered cartilage
- (2012) Jiewen Dai et al. BIOMATERIALS
- Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor
- (2012) Regina Goetz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast growth factor control of cartilage homeostasis
- (2012) M.B. Ellman et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Role of FGFs/FGFRs in skeletal development and bone regeneration
- (2012) Xiaolan Du et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Palatal and Oral Manifestations of Muenke Syndrome (FGFR3-Related Craniosynostosis)
- (2012) Nneamaka Barbara Agochukwu et al. JOURNAL OF CRANIOFACIAL SURGERY
- Unlike Bone, Cartilage Regeneration Remains Elusive
- (2012) D. J. Huey et al. SCIENCE
- The Alternatively Spliced Acid Box Region Plays a Key Role in FGF Receptor Autoinhibition
- (2012) Juliya Kalinina et al. STRUCTURE
- Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
- (2012) Tom D. Bunney et al. STRUCTURE
- Mild isolated craniosynostosis due to a novel FGFR3 mutation, p.Ala334Thr
- (2011) Eva Barroso et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
- (2011) F. W. Roemer et al. ANNALS OF THE RHEUMATIC DISEASES
- Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development
- (2011) Caroline J. Sheeba et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
- (2011) N. Itoh et al. JOURNAL OF BIOCHEMISTRY
- Osteoarthritis: an update with relevance for clinical practice
- (2011) Johannes WJ Bijlsma et al. LANCET
- Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes
- (2011) Dongyao Yan et al. ARTHRITIS RESEARCH & THERAPY
- Heparan Sulfate Proteoglycans
- (2011) S. Sarrazin et al. Cold Spring Harbor Perspectives in Biology
- Analysis of meniscal degeneration and meniscal gene expression
- (2010) Yubo Sun et al. BMC MUSCULOSKELETAL DISORDERS
- Epidemiology of Osteoarthritis
- (2010) Yuqing Zhang et al. CLINICS IN GERIATRIC MEDICINE
- PKC and the control of localized signal dynamics
- (2010) Carine Rosse et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
- (2010) J. H. Bae et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optimization of an In Vitro Three-Dimensional Microenvironment to Reprogram Synovium-Derived Stem Cells for Cartilage Tissue Engineering
- (2010) Jingting Li et al. TISSUE ENGINEERING PART A
- Enhanced Proliferation and Chondrogenic Differentiation of Human Synovium-Derived Stem Cells Expanded with Basic Fibroblast Growth Factor
- (2010) Ji Hyun Kim et al. TISSUE ENGINEERING PART A
- Multiple Synostoses Syndrome Is Due to a Missense Mutation in Exon 2 of FGF9 Gene
- (2009) Xiao-lin Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis
- (2009) Shi-Lu Chia et al. ARTHRITIS AND RHEUMATISM
- Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
- (2009) Raymond B Birge et al. Cell Communication and Signaling
- rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival and α-SMA expression in human meniscal lesions
- (2009) M Cucchiarini et al. GENE THERAPY
- An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation
- (2009) Moez Gribaa et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Structural and Functional Basis of a Role for CRKL in a Fibroblast Growth Factor 8-Induced Feed-Forward Loop
- (2009) J.-H. Seo et al. MOLECULAR AND CELLULAR BIOLOGY
- The FGF family: biology, pathophysiology and therapy
- (2009) Andrew Beenken et al. NATURE REVIEWS DRUG DISCOVERY
- Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
- (2009) R. Goetz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis
- (2009) H. P. Makarenkova et al. Science Signaling
- Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
- (2008) Yasunobu Sawaji et al. ARTHRITIS AND RHEUMATISM
- Glycosaminoglycan affinity of the complete fibroblast growth factor family
- (2008) Masahiro Asada et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
- (2008) Noriko Gotoh CANCER SCIENCE
- Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform
- (2008) Jiyoung Y. Cha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning
- (2008) Francesca V. Mariani et al. NATURE
- The Complex Genetics of Kallmann Syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al.
- (2008) J.-P. Hardelin et al. Sexual Development
- The role of fibroblast growth factor-8 (FGF8) in animal models of osteoarthritis
- (2008) Masako Uchii et al. ARTHRITIS RESEARCH & THERAPY
- The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
- (2007) Marie Dance et al. CELLULAR SIGNALLING
- Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes
- (2007) Hee-Jeong Im et al. JOURNAL OF CELLULAR PHYSIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now