Article
Neurosciences
Yulou Yu, Jing Yang, Feng Luan, Guoqiang Gu, Ran Zhao, Qiong Wang, Zishan Dong, Junming Tang, Wei Wang, Jinpeng Sun, Ping Lv, Hailin Zhang, Chuan Wang
Summary: Deafness is known to occur in more than 400 syndromes, with Fgf13 gene mutations being a common feature in three main syndromes. Knockout of the Fgf13 gene in the inner ear of mice led to sensorineural deafness, apoptotic cell death mediated the loss of SGNs. This study suggests a novel role for Fgf13 in auditory function and potential candidate for understanding deafness.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Dezhong Wang, Yuan Yin, Shuyi Wang, Tianyang Zhao, Fanghua Gong, Yushuo Zhao, Beibei Wang, Yuli Huang, Zizhao Cheng, Guanghui Zhu, Zengshou Wang, Yang Wang, Jun Ren, Guang Liang, Xiaokun Li, Zhifeng Huang
Summary: Research has shown that FGF1 levels are decreased in DCM patients and positively correlated with fraction shortening, potentially making it a therapeutic target. Treatment with FGF1 variant FGF1( increment HBS) can prevent diabetes-induced cardiac injury and remodeling through effects on anti-oxidative gene expression and Nur77 levels. FGF1( increment HBS) exerts its beneficial effects by reducing mitochondrial fragmentation, ROS generation, and cytochrome c leakage, as well as enhancing mitochondrial respiration and beta-oxidation, all in an AMPK/Nur77-dependent manner.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Aurelien Justet, Mada Ghanem, Tiara Boghanim, Mouna Hachem, Eirini Vasarmidi, Madeleine Jaillet, Aurelie Vadel, Audrey Joannes, Pierre Mordant, Philippe Bonniaud, Martin Kolb, Lei Ling, Aurelie Cazes, Herve Mal, Arnaud Mailleux, Bruno Crestani
Summary: This study identifies FGF19 as an antifibrotic molecule with potential therapeutic interest in fibrotic lung disorders. In vivo and in vitro experiments demonstrate that FGF19 can decrease lung fibrosis and fibrotic markers, modulate apoptosis of lung epithelial cells, and prevent myofibroblast differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Immunology
Yi-nan Pan, Chao Jia, Jia-pei Yu, Zhou-wei Wu, Guo-chao Xu, Yi-xing Huang
Summary: This study found that fibroblast growth factor 9 (FGF9) can reduce oxidative stress in chondrocytes and prevent the progression of osteoarthritis (OA) by activating the ERK and Nrf2-HO1 signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sheng Lu, Chao-Wei Lin
Summary: FGF-18 alleviated intervertebral disc degeneration by inhibiting nucleus pulposus cell apoptosis and the expression of matrix-degrading enzymes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Oncology
Yiming Zhou, Sizheng Sun, Tao Ling, Yongzhen Chen, Rongzhong Zhou, Qiang You
Summary: FGF18, a member of the FGF family, can promote the occurrence and development of malignant tumors in various systems and has significant clinical implications as a potential therapeutic target and prognostic biomarker.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Summary: This article reports on the mechanisms controlling the population numbers of different cell types in animal tissues. The study shows that fibroblasts are limited in proliferation due to space availability, while macrophages are constrained by growth factor availability. The transcriptional coactivator YAP1 in fibroblasts directly regulates the expression of the macrophage-specific growth factor Csf1. The findings suggest that tissue environment sensing is a general strategy for controlling tissue composition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Jan Vilim, Tereza Ghazalova, Eliska Petulova, Aneta Horackova, Veronika Stepankova, Radka Chaloupkova, David Bednar, Jiri Damborsky, Zbynek Prokop
Summary: Researchers have successfully enhanced the stability of FGF18 through rational protein engineering, resulting in a stable variant called FGF18-E4, which shows promise in treating osteoarthritis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Gherardo Baudo, Suhong Wu, Matteo Massaro, Haoran Liu, Hyunho Lee, Aijun Zhang, Dale J. Hamilton, Elvin Blanco
Summary: This study aimed to investigate whether improving mitochondrial function can attenuate fibroblast-to-myofibroblast transition (FMT) stimulated by transforming growth factor-beta (TGF-beta). The results demonstrated that administering Dex-TPP-coated mitochondria to TGF-beta-stimulated fibroblasts can inhibit the shift towards glycolysis, reduce reactive oxygen species (ROS) generation, and decrease the expression of FMT markers and extracellular matrix (ECM) proteins, as well as migration and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Pengfei Zhu, Zhengchao Wang, Zhenxing Sun, Bokai Liao, Yu Cai
Summary: The study found that recombinant PDGF-BB alleviated OA by inhibiting chondrocyte apoptosis, reducing cartilage hyperplasia, and regulating collagen metabolism.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Dupiao Zhang, Mazhar Ali Raza, Jianpeng Chen, Baolong Li, Wenbin Liu, Tao Han, Hede Yan, Liangfu Jiang
Summary: In this study, the researchers used a mouse model to investigate the effects of FGF9 on random flap survival. The results showed that FGF9 can directly increase flap survival area and blood flow intensity by promoting angiogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Jiarui Cui, Yo Shibata, Tianmin Zhu, Jun Zhou, Jiaming Zhang
Summary: Osteocytes play a critical role in maintaining bone homeostasis and are involved in age-related bone deterioration. Studies have identified specific characteristics and molecular mechanisms of aging osteocytes, such as impaired mechanosensitivity and cellular senescence. RNA sequencing has provided insights into bone aging-related genes and signaling pathways in osteocytes.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell & Tissue Engineering
X. Hao, J. Zhang, X. Shang, K. Sun, J. Zhou, J. Liu, R. Chi, T. Xu
Summary: Exercise is effective at maintaining the integrity of the cartilage-subchondral bone unit in post-traumatic osteoarthritis (PTOA). This study revealed that exercise reduces systemic inflammation and microbiome-derived metabolites in PTOA. The changes in the gut microbiome may contribute to the beneficial effects of exercise on PTOA.
BONE & JOINT RESEARCH
(2022)
Article
Genetics & Heredity
Jiaming Zhang, Xiaoxia Hao, Ruimin Chi, Jiawei Liu, Xingru Shang, Xiaofeng Deng, Jun Qi, Tao Xu
Summary: This study explored the effects of mechanical stress on the transcriptome landscape of chondrocytes and identified an immune- and metabolism-related non-coding RNA transcriptome signature responsive to mechanical stress.
FRONTIERS IN GENETICS
(2022)
Article
Cell & Tissue Engineering
J. Zhou, Z. He, J. Cui, X. Liao, H. Cao, Y. Shibata, T. Miyazaki, J. Zhang
Summary: This study identified a mechanics-responsive osteocyte signature in OA-lesioned subchondral bone. These genes are closely associated with osteocyte functions and signaling pathways.
BONE & JOINT RESEARCH
(2022)
Article
Clinical Neurology
Zhengtao Lv, Jiarui Cui, Jiaming Zhang
Summary: This study used Mendelian Randomization (MR) method to assess the causal relationships between smoking initiation, alcohol consumption, coffee consumption and the risk of Low Back Pain (LBP). The results showed that smoking initiation is causally associated with an increased risk of LBP, while there is no causal effect of alcohol and coffee consumption on LBP. This study provides important insights for the management and treatment of LBP patients.
EUROPEAN SPINE JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Jiarui Cui, Jiaming Zhang
Summary: Cartilage oligomeric matrix protein (COMP) plays a critical role in collagen assembly and ECM stability in the extracellular matrix. Mutations in COMP can lead to endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. COMP acts as a bridging molecule with its bouquet-like structure, regulating cellular phenotype and function by interacting with ECM components, cellular receptors, and growth factors. Recent studies suggest that COMP may also be involved in other skeleton diseases, malignancy, cardiovascular diseases, and tissue fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Jiarui Cui, Yo Shibata, Keiji Itaka, Jun Zhou, Jiaming Zhang
Summary: This study used bioinformatic analyses to identify the impact of exercise on cartilage transcriptome, revealing that exercise suppressed genes related to various cellular functions and inflammatory responses, with downregulated genes being more stable over time. Additionally, the study identified time-related signaling pathways and clusters of genes responsive to exercise duration, advancing the understanding of cartilage homeostasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, Liu Mei, Ying Wang, Xianming Tan, Austin J. Hepperla, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu
Summary: The expression of STING is increased in renal cell carcinoma (RCC) patients and it plays a role in regulating mitochondrial function and growth through non-canonical innate immune signaling. STING interacts with VDAC2 to affect mitochondrial ROS and calcium levels, leading to the suppression of mTORC1/S6K signaling. These findings reveal an innate immunity-independent function of STING in RCC.
Article
Immunology
Zhengtao Lv, Jiarui Cui, Jiaming Zhang
Summary: This study found a negative association between serum urate levels and telomere length, but no association with serum soluble inflammation markers. This suggests that telomere length may be a critical marker for urate-related organismal aging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jiaming Zhang, Baofang Zhang, Congli Pu, Jiarui Cui, Kexin Huang, Hongbo Wang, Yingchao Zhao
Summary: A novel nanoliposomal DT2216 (DT@NPs) was developed for targeting Bcl-xL, which exhibited enhanced ability to degrade Bcl-xL and induce apoptosis in cervical and breast cancer cells compared to DT2216. In a mouse model, DT@NPs showed stronger inhibition of tumor growth. DT@NPs also had notable cytocompatibility in normal cells and good biodistribution in vivo.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Junlai Wan, Zhiyi He, Yingchao Zhao, Xiaoxia Hao, Jiarui Cui, Anmin Chen, Jun Zhou, Jiaming Zhang
Summary: This study investigates the potential of multi-kinase inhibitor Y099 in senescence elimination and osteoarthritis (OA) therapy. Y099 inhibits inflammation and catabolism, and promotes anabolism of chondrocytes. The delivery of Y099 by nanoliposomal hydrogel improves its performance and reduces cytotoxicity. Y099-Lip-Gel attenuates cartilage lesions and inhibits subchondral bone loss and osteoclast formation in an OA mouse model, indicating its potential for OA therapy. Transcriptomic and phosphoproteomic analyses reveal that Y099-Lip-Gel suppresses cellular senescence and inhibits MAPK and NF-kappa B signaling activations. The protective effects of Y099-Lip-Gel are also validated in human OA cartilage explants. Rating: 8/10
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Junlai Wan, Zhiyi He, Renpeng Peng, Xiaopei Wu, Ziqing Zhu, Jiarui Cui, Xiaoxia Hao, Anmin Chen, Jiaming Zhang, Peng Cheng
Summary: This study developed a novel approach for osteoarthritis (OA) treatment by overcoming the limitations of bone marrow mesenchymal stromal cell-derived exosomes (Exo) in drug delivery. The engineered Exo, encapsulated in photocrosslinking spherical gelatin methacryloyl hydrogel (GelMA) and modified with a cartilage affinity peptide, showed effective targeting effects on chondrocytes and demonstrated superior anti-OA activity and cartilage repair ability in both in vitro and in vivo experiments.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhengtao Lv, Jiaming Zhang, Shuang Liang, Chenhe Zhou, Dorothy Hu, Daniel J. Brooks, Mary L. Bouxsein, Beate Lanske, Paul Kostenuik, Francesca Gori, Roland Baron
Summary: This study compares the effects of ABL and TPTD on osteocytes and skeletal responses. The results show that ABL has stronger effects on cortical bone and affects the osteocyte transcriptome differently compared to TPTD.
Review
Chemistry, Multidisciplinary
Zhongyang Zhang, Jun Zhou, Chuang Liu, Jiaming Zhang, Yo Shibata, Na Kong, Claudia Corbo, Mitchel B. Harris, Wei Tao
Summary: Biomimetic nanotechnology plays an important role in the treatment of orthopedic diseases by restoring the structure and function of bone tissue and improving therapeutic efficacy. Understanding the pathogenesis can optimize treatment strategies. However, there are still challenges and unmet needs that hinder the clinical implementation of biomimetic nanotechnology.
TRENDS IN CHEMISTRY
(2022)