Advances in treatment of achondroplasia and osteoarthritis

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Meclozine Promotes Longitudinal Skeletal Growth in Transgenic Mice with Achondroplasia Carrying a Gain-of-Function Mutation in theFGFR3Gene

(2015) Masaki Matsushita et al.   ENDOCRINOLOGY

C-Type Natriuretic Peptide Plasma Levels Are Elevated in Subjects With Achondroplasia, Hypochondroplasia, and Thanatophoric Dysplasia

(2015) Robert C. Olney et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gene therapy approaches to regenerating the musculoskeletal system

(2015) Christopher H. Evans et al.   Nature Reviews Rheumatology

Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

(2014) Akihiro Yamashita et al.   NATURE

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Use of Tissue Engineering Strategies to Repair Joint Tissues in Osteoarthritis: Viral Gene Transfer Approaches

(2014) Magali Cucchiarini et al.   Current Rheumatology Reports

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells

(2013) A. T. Martino et al.   BLOOD

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

(2013) Masaki Matsushita et al.   PLoS One

Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice

(2013) S. Garcia et al.   Science Translational Medicine

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

(2013) Laurie R Goodrich et al.   Molecular Therapy-Nucleic Acids

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

(2012) Florence Lorget et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FGFR3 targeting strategies for achondroplasia

(2012) Melanie B. Laederich et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

(2012) Min Jin et al.   HUMAN MOLECULAR GENETICS

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

(2012) Robert C Münch et al.   MOLECULAR THERAPY

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of C-type natriuretic peptide expression

(2011) Donald F. Sellitti et al.   PEPTIDES

Achondroplasia: pathogenesis and implications for future treatment

(2010) Melanie B Laederich et al.   CURRENT OPINION IN PEDIATRICS

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Getting arthritis gene therapy into the clinic

(2010) Christopher H. Evans et al.   Nature Reviews Rheumatology

Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice

(2009) Takei Kake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias

(2009) Akihiro Yasoda et al.   ENDOCRINOLOGY

Ex Vivo Serotype-Specific Transduction of Equine Joint Tissue by Self-Complementary Adeno-Associated Viral Vectors

(2009) L.R. Goodrich et al.   HUMAN GENE THERAPY

FGFs in endochondral skeletal development

(2009) William A. Horton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Current perspective – Trastuzumab

(2008) Peter S. Hall et al.   EUROPEAN JOURNAL OF CANCER

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

(2008) L. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA