The role of metabolism in the pathogenesis of osteoarthritis

Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings

(2017) Marie Monlun et al.   JOURNAL OF MOLECULAR BIOLOGY

Leptin in the interplay of inflammation, metabolism and immune system disorders

(2017) Vanessa Abella et al.   Nature Reviews Rheumatology

The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases

(2017) Pallavi Bhattaram et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction

(2017) Daniel Salinas et al.   PLoS One

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

(2016) Maryam Rahmati et al.   BONE

PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage

(2016) Jining Qu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Age-Related Alterations in Signaling Pathways in Articular Chondrocytes: Implications for the Pathogenesis and Progression of Osteoarthritis - A Mini-Review

(2016) Peter van der Kraan et al.   GERONTOLOGY

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis

(2016) Ronald K. June et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Immunometabolism: Is it under the eye of the clock?

(2016) James O. Early et al.   SEMINARS IN IMMUNOLOGY

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1

(2016) Xu Cui et al.   Scientific Reports

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

Is osteoarthritis a metabolic disorder?

(2015) S. Kluzek et al.   BRITISH MEDICAL BULLETIN

Biologic basis of osteoarthritis

(2015) Charles J. Malemud   CURRENT OPINION IN RHEUMATOLOGY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

The role of hedgehog signalling in skeletal health and disease

(2015) Benjamin A. Alman   Nature Reviews Rheumatology

CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study

(2015) D. Misra et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic triggered inflammation in osteoarthritis

(2015) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis

(2015) Martijn H. van den Bosch et al.   RHEUMATOLOGY

Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

(2015) AS Siebuhr et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis

(2015) Shan-Chi Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glucose-6-phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis

(2015) Ming Zong et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial respiration and redox coupling in articular chondrocytes

(2015) Rachel S Lane et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

(2015) Yuta Onodera et al.   FEBS Open Bio

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis

(2014) Beata Mickiewicz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of mitochondrial reactive oxygen species in cartilage matrix destruction

(2014) Kendra N. Reed et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

(2014) E. Thijssen et al.   RHEUMATOLOGY

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

(2014) Koji Takayama et al.   ARTHRITIS RESEARCH & THERAPY

Classification of osteoarthritis phenotypes by metabolomics analysis

(2014) Weidong Zhang et al.   BMJ Open

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

(2014) Xianling Zhao et al.   Arthritis & Rheumatology

Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals

(2013) Javier Conde et al.   ANNALS OF THE RHEUMATIC DISEASES

Value of biomarkers in osteoarthritis: current status and perspectives

(2013) M Lotz et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture

(2013) Berta Cillero-Pastor et al.   BMC MUSCULOSKELETAL DISORDERS

Adipokines as drug targets in joint and bone disease

(2013) Morena Scotece et al.   DRUG DISCOVERY TODAY

Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases

(2013) Xiaozhen Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is osteoarthritis a metabolic disease?

(2013) Jérémie Sellam et al.   JOINT BONE SPINE

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Oxidative stress and status of antioxidant enzymes in children with Kashin–Beck disease

(2013) W. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

C/EBP homologous protein drives pro-catabolic responses in chondrocytes

(2013) Matt Husa et al.   ARTHRITIS RESEARCH & THERAPY

Synovium and the Innate Inflammatory Network in Osteoarthritis Progression

(2013) Ru Liu-Bryan   Current Rheumatology Reports

The Future of Osteoarthritis Therapeutics: Emerging Biological Therapy

(2013) A. Mobasheri   Current Rheumatology Reports

Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis

(2012) Barbara Muz et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis

(2012) David J. Hunter   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation

(2012) Chun-Hao Tsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Metabolomic characterization of metabolic phenotypes in OA

(2012) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Tackling obesity in knee osteoarthritis

(2012) Anita E. Wluka et al.   Nature Reviews Rheumatology

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Mitochondrial electron transport and glycolysis are coupled in articular cartilage

(2012) J.A. Martin et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

(2012) M. Mahjoub et al.   OSTEOPOROSIS INTERNATIONAL

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis

(2011) Akihiko Hasegawa et al.   ARTHRITIS AND RHEUMATISM

Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice

(2011) L. M. Gierman et al.   ARTHRITIS AND RHEUMATISM

Diagnosis of osteoarthritis: Imaging

(2011) Hillary J. Braun et al.   BONE

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Global metabolic profiling of human osteoarthritic synovium

(2011) S.B. Adams et al.   OSTEOARTHRITIS AND CARTILAGE

The metabolic life and times of a T-cell

(2010) Ryan D. Michalek et al.   IMMUNOLOGICAL REVIEWS

Oxidant conditioning protects cartilage from mechanically induced damage

(2010) Prem Ramakrishnan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin–Beck disease

(2010) J.T. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

The role of synovitis in osteoarthritis

(2010) Claire Y. J. Wenham et al.   Therapeutic Advances in Musculoskeletal Disease

Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articular cartilage and intervertebral disc tissue engineering

(2009) Stephen M. Richardson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

(2009) Rodolfo Gomez et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up

(2008) Margreth Grotle et al.   BMC MUSCULOSKELETAL DISORDERS

Effects of hypoxia on glucose transport in primary equine chondrocytesin vitroand evidence of reduced GLUT1 gene expression in pathologic cartilagein vivo

(2008) Siriporn Peansukmanee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes

(2008) V.I. Grishko et al.   OSTEOARTHRITIS AND CARTILAGE

4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase

(2008) France Vaillancourt et al.   ARTHRITIS RESEARCH & THERAPY

The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis

(2007) Saski Sutton et al.   VETERINARY JOURNAL