Article
Chemistry, Multidisciplinary
De-pu Zhou, Lian-cheng Deng, Xiao Feng, Hui-jing Xu, Ye Tian, Wei-wei Yang, Ping-ping Zeng, Li-hui Zou, Xi-hua Yan, Xia-yan Zhu, Dan-hua Shu, Qiang Guo, Xiao-ying Huang, Saverio Bellusci, Zhenkun Lou, Xiao-kun Li, Jin-San Zhang
Summary: This study demonstrates that FGF10 protects against doxorubicin-induced myocardial injury through activation of the FGFR2/PHLDA1/Akt axis. These findings reveal a potent protective effect of FGF10 against doxorubicin-induced cardiac toxicity and identify the FGFR2b/PHLDA1/Akt axis as a potential therapeutic target for patients receiving doxorubicin treatment.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Cell Biology
Matthew R. Jones, Lei Chong, Saverio Bellusci
Summary: The development of airway branching relies on the coordination of various biological and physical factors across different spatial scales, with the Fgf10/Fgfr2b signaling pathway playing a key role. While fine reviews on molecular mechanisms related to branching morphogenesis have been published, a comprehensive review covering all major factors involved in branching and the role of Fgf10/Fgfr2b is lacking. This review aims to summarize existing literature on airway branching morphogenesis, emphasizing the impact of biophysical and mechanical forces, extracellular matrix remodeling, and other pulmonary networks on the process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Emma N. Finburgh, Olivier Mauduit, Takako Noguchi, Jennifer J. Bu, Anser A. Abbas, Dominic F. Hakim, Saverio Bellusci, Robyn Meech, Helen P. Makarenkova, Natalie A. Afshari
Summary: This study aimed to characterize the role of FGF10 in adult eye structures. The researchers found that FGF10 promotes regeneration in damaged lacrimal glands and corneal epithelium proliferation. These findings have important therapeutic potential for treating dry eye disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Xuming Zhu, Makoto Senoo, Sarah E. Millar, Gang Ma
Summary: The study investigates the role of Wnt/beta-catenin signaling in mouse eyelid development. Disruption of the signaling pathway by deleting beta-catenin or Wls in specific tissues leads to abnormal eyelid growth. The expression of Wnt ligands is regulated by p63. This study reveals the importance of Wnt signaling in eyelid development.
Article
Biochemistry & Molecular Biology
Jinxi Li, James D. Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C. Zheng, Edie Crosse, Alexander Medvinsky, Richard A. Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P. Kemp, Yvonne Y. W. Ho, Danuta Z. Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G. Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M. Chernus, Katherine Neiswanger, Eleanor Feingold, David M. Evans, Sarah E. Medland, Nicholas G. Martin, Seth M. Weinberg, Mary L. Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin, Denis J. Headon, Sijia Wang
Summary: This study conducted genome-wide scans in Han Chinese cohorts and identified 18 loci associated with fingerprint type, as well as a genetic basis for the recognized pattern-block correlations. Additionally, a variant near EVI1 was found to alter regulatory activity and play a role in dermatoglyph patterning. Trans-ethnic meta-analysis identified 43 fingerprint-associated loci and revealed a genetic correlation between fingerprint patterns and hand proportions. These findings highlight the importance of limb development genes in shaping fingerprint patterning.
Article
Biochemistry & Molecular Biology
Fen Ji, Chao Feng, Jie Qin, Chong Wang, Dongming Zhang, Libo Su, Wenwen Wang, Mengtian Zhang, Hong Li, Longbing Ma, Weicheng Lu, Changmei Liu, Zhaoqian Teng, Baoyang Hu, Fengzeng Jian, Jingdun Xie, Jianwei Jiao
Summary: The deletion of Pd1 in the brain leads to abnormal cortical neurogenesis and depressive-like behaviors. Pd1 regulates neurogenesis by targeting Pax3 through the β-catenin signaling pathway. Furthermore, Pd1 also plays a similar role in the proliferation and differentiation of human neural progenitor cells (hNPCs).
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Nkiruka Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A. Walker, Mostafa Belghasem, Jonathan D. Ravid, Mohamed Hassan Kamel, Stephen A. Whelan, Norman Lee, Jeffrey J. Siracuse, Stephan Anderson, Alik Farber, David Sherr, Jean Francis, Naomi M. Hamburg, Nader Rahimi, Vipul C. Chitalia
Summary: Chronic kidney disease (CKD) is an independent risk factor for peripheral artery disease (PAD). The role of uremic solutes retained in CKD patients in PAD is not well understood. This study reveals that tryptophan-derived uremic solutes inhibit beta-catenin, a key regulator of angiogenesis, in several cell types including endothelial cells. These solutes downregulate beta-catenin through the aryl hydrocarbon receptor (AHR). CKD mouse models show reduced beta-catenin and blood vessel density in ischemic limbs, which correlates with increased levels of uremic solutes and AHR activity. In a cohort of PAD patients, higher plasma levels of tryptophan metabolites and increased AHR-inducing activity in endothelial cells are associated with an increased risk of adverse limb events. Targeting the tryptophan metabolite/AHR/beta-catenin axis may provide new therapeutic strategies for PAD in CKD patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Chengming Zhang, Zhiyi Liu, Xiaotian Wang, Bin Zhang, Licheng Cui, Qinghe Hu, Bin Hu, Kuan Cao, Wengang Shan, Hengliang Shi, Renhao Wang
Summary: In this study, it was found that CTSK interacts with SIAH1 and inhibits its protein level, leading to increased proliferation of hepatocellular carcinoma (HCC) cells. CTSK mediates SIAH1 ubiquitination and degradation by promoting SIAH1 autoubiquitination and recruiting NEDD4 as an upstream ubiquitin ligase. These findings highlight the oncogenic role of CTSK in HCC progression.
Article
Oncology
Nicolas Penel, Sylvie Bonvalot, Andre-Michel Bimbai, Alexandra Meurgey, Francois Le Loarer, Sebastien Salas, Sophie Piperno-Neumann, Christine Chevreau, Pascaline Boudou-Rouquette, Pascale Dubray-Longeras, Jean-Emmanuel Kurtz, Cecile Guillemet, Emmanuelle Bompas, Antoine Italiano, Axel Le Cesne, Daniel Orbach, Julien Thery, Marie-Cecile Le Deley, Jean-Yves Blay, Olivier Mir
Summary: This prospective nationwide cohort study aimed to investigate the outcomes of desmoid-type fibromatosis (DF), focusing on the prognostic value of CTNNB1 mutations. The results showed that CTNNB1 mutation profile was associated with unfavorable prognostic factors but was not a prognostic factor for event-free survival (EFS).
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou, Yong Peng
Summary: The study revealed that craniopharyngioma (CP) has fewer somatic mutations compared to malignant tumors, and mutations in CTNNB1 in adamantinomatous-type CP (ACP) and BRAF V600E in papillary-type CP (PCP) are mutually exclusive. A novel mutation in exon 3 of CTNNB1 was identified, showing that it can activate the Wnt-signaling pathway by increasing beta-catenin stability and promoting cell proliferation through experimental validation.
Article
Biochemistry & Molecular Biology
Shotaro Isozaki, Hiroki Tanaka, Kie Horioka, Hiroaki Konishi, Shin Kashima, Shuhei Takauji, Mikihiro Fujiya, Henrik Druid
Summary: This study elucidates the molecular dynamics of frostbite using a mouse frostbite model and keratinocyte cell culture. The activation of beta-catenin signaling and its nuclear translocation are observed in frostbite, and this process is associated with hypoxia. Beta-catenin promotes keratinocyte motility and tissue repair, as shown by the suppression of epithelial-mesenchymal transition and in vitro wound healing activity when beta-catenin is inhibited.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Derek C. Liberti, Edward E. Morrisey
Summary: Organoids derived from various lung cell types offer a reproducible model for understanding complex signals driving cell fate decisions in a regenerative context. Integrating organoid assays with in vivo modeling helps explore responses of different niches and compartments in the respiratory system to acute and chronic lung diseases. Strategic implementation and improvement of organoid techniques provide exciting opportunities to identify new therapeutic approaches for lung disease states.
TRENDS IN MOLECULAR MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Arundhathi Dev, Meenakshi Vachher, Chandra Prakash Prasad
Summary: beta-catenin is a crucial protein involved in various cellular processes, including cellular homeostasis, embryonic development, and cancer. It functions as a signaling molecule and also plays a role in cell adhesion. Aberrant expression of beta-catenin promotes the transcription of oncogenes and contributes to tumorigenesis. Understanding the regulation of beta-catenin is important for understanding the mechanisms of cancer progression.
Article
Pharmacology & Pharmacy
Ilandarage Menu Neelaka Molagoda, Chang-Hee Kang, Mi-Hwa Lee, Yung Hyun Choi, Chang-Min Lee, Seungheon Lee, Gi-Young Kim
Summary: Fisetin enhances osteogenic activity, promotes vertebral formation in zebrafish larvae, inhibits anti-osteoblastic genes induced by prednisolone, and activates the GSK-3 beta/beta-catenin signaling pathway to stimulate osteogenesis.
BIOCHEMICAL PHARMACOLOGY
(2021)