- Home
- Publications
- Publication Search
- Publication Details
Title
PI3K and AKT: Unfaithful Partners in Cancer
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 9, Pages 21138-21152
Publisher
MDPI AG
Online
2015-09-03
DOI
10.3390/ijms160921138
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
- (2015) Carlotta Costa et al. CANCER CELL
- Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
- (2015) Sarit Schwartz et al. CANCER CELL
- DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
- (2015) Jogitha Selvarajah et al. Oncotarget
- 3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner
- (2015) Paolo Armando Gagliardi et al. NEOPLASIA
- SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
- (2014) Jessica A. Gasser et al. MOLECULAR CELL
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects
- (2013) Marc Dufour et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
- (2013) Kenta Masui et al. Cell Metabolism
- PAK1 Mediates Resistance to PI3K Inhibition in Lymphomas
- (2013) K. Walsh et al. CLINICAL CANCER RESEARCH
- Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma
- (2013) Victoria Marsh Durban et al. JOURNAL OF CLINICAL INVESTIGATION
- Development of PI3K inhibitors: lessons learned from early clinical trials
- (2013) Jordi Rodon et al. Nature Reviews Clinical Oncology
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
- (2013) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
- PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1
- (2013) H. Ebi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy
- (2013) M. Weiler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer
- (2012) Adrian Britschgi et al. CANCER CELL
- The Genetic Basis for Cancer Treatment Decisions
- (2012) Janet E. Dancey et al. CELL
- PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics
- (2012) Kiran Mahajan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- PI3K signalling: the path to discovery and understanding
- (2012) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies
- (2012) Shubha Bagrodia et al. Pigment Cell & Melanoma Research
- GS-1101: A Delta-Specific PI3K Inhibitor in Chronic Lymphocytic Leukemia
- (2012) Ines M. Macias-Perez et al. Current Hematologic Malignancy Reports
- AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
- (2011) Sarat Chandarlapaty et al. CANCER CELL
- PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
- (2011) K. Ellwood-Yen et al. CANCER RESEARCH
- The diverse roles of Rac signaling in tumorigenesis
- (2011) Natalie A. Mack et al. CELL CYCLE
- IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation
- (2011) Jian-Ping Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
- (2011) V Serra et al. ONCOGENE
- The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer
- (2011) Jatin Roper et al. PLoS One
- Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
- (2011) A. Chakrabarty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- I B kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation
- (2011) X. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance
- (2011) K. Tanaka et al. Cancer Discovery
- Second AKT: The rise of SGK in cancer signalling
- (2010) Maressa A. Bruhn et al. GROWTH FACTORS
- The PI3K Pathway As Drug Target in Human Cancer
- (2010) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1
- (2010) S. M. Joung et al. JOURNAL OF IMMUNOLOGY
- Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
- (2010) Didier Roulin et al. Molecular Cancer
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
- (2010) Kiran Mahajan et al. PLoS One
- mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
- (2009) David A. Guertin et al. CANCER CELL
- AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
- (2009) Krishna M. Vasudevan et al. CANCER CELL
- Targeting the PI3K signaling pathway in cancer
- (2009) Kwok-Kin Wong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Shifting paradigms: the seeds of oncogene addiction
- (2009) Charles L Sawyers NATURE MEDICINE
- An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
- (2008) K. Stemke-Hale et al. CANCER RESEARCH
- Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival
- (2008) P. C. McDonald et al. CANCER RESEARCH
- Acquired resistance to tyrosine kinase inhibitors during cancer therapy
- (2008) Jeffrey A Engelman et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started