Article
Cell & Tissue Engineering
H. Wang, Y. Shi, F. He, T. Ye, S. Yu, H. Miao, Q. Liu, M. Zhang
Summary: Abnormal adipogenesis and decreased expression of GDF11 were observed in degenerative cartilage of TMJ OA. Supplementation of GDF11 effectively inhibits adipogenesis of chondrocytes and alleviates TMJ condylar cartilage degeneration. GDF11 may inhibit abnormal adipogenesis of chondrocytes by affecting the SUMOylation of PPAR gamma.
BONE & JOINT RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Li Liu, Yaping Feng, Shiyu Hu, Huimin Li, Yanyan Li, Jin Ke, Xing Long
Summary: The study revealed that PDCD4 is highly expressed in cartilage from MIA-induced TMJOA rats, inhibiting autophagy and promoting apoptosis. Furthermore, Akt mediates PDCD4-induced apoptosis and inhibited autophagy.
Review
Cell Biology
Baochao Li, Guangzhao Guan, Li Mei, Kai Jiao, Huang Li
Summary: TMJ osteoarthritis is characterized by chondrocyte death, ECM degradation, and subchondral bone remodeling. Chondrocyte hypertrophy and cartilage angiogenesis are important factors in the pathogenesis of TMJ osteoarthritis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Orthopedics
Melissa Franklin, Megan M. Sperry, Evan Phillips, Eric J. Granquist, Michele Marcolongo, Beth A. Winkelstein
Summary: Mechanical stress to the temporomandibular joint (TMJ) plays an important role in cartilage degeneration, potentially leading to joint pain, inflammation, and structural damage. This study found that the relationship between pain severity and early signs of cartilage matrix microstructural dysregulation is unclear, posing challenges for the diagnosis and treatment of temporomandibular joint-osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Orthopedics
H. R. Matheus, S. D. Ozdemir, F. P. S. Guastaldi
Summary: Stem cell-based therapies have the potential for treating Temporomandibular Joint Osteoarthritis (TMJ-OA) and regenerating cartilage/osteochondral defects. Regardless of cell origin, stem cell-based therapeutic approaches exhibit protective, anti-inflammatory, and chondroregenerative potential in the treatment of TMJ-OA.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Endocrinology & Metabolism
Benyi Yang, Xin Li, Chaoran Fu, Wenyi Cai, Bowen Meng, Yan Qu, Xiaoxing Kou, Qingbin Zhang
Summary: Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. Extracellular vesicles (EVs), such as exosomes and microvesicles, play an essential role in the progression and treatment of OA, regulating tissue homeostasis and cell-to-cell communication. Synovial fluid and synovium-derived EVs have been identified as potential biomarkers for OA, and mesenchymal stem cell-derived EVs have shown therapeutic effects. However, the different functions of EVs in knee joint and temporomandibular joint (TMJ) are not well understood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Dong He, Jing Wang, Yanhua Li, Gaoyi Wu, Guoxiong Zhu, Lei Chen
Summary: TMJ-OA causes pain and decreased quality of life, and studies have found that LIPUS protects chondrocytes by increasing the expression of aggrecan through ZNT-9 regulation.
Article
Biotechnology & Applied Microbiology
Liping Xiong, Han Bao, Size Li, Deao Gu, Yuyang Li, Qianwen Yin, Wen Li, Leiying Miao, Chao Liu
Summary: This study demonstrated that cerium oxide nanoparticles (CNPs) have powerful antioxidant properties and can protect chondrocytes and cartilage against the damage of osteoarthritis. The activation of the Nrf2/HO-1 signaling pathway by CNPs may have therapeutic potential for temporomandibular joint osteoarthritis (TMJ-OA).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Ke Lu, Feng Ma, Dan Yi, Huan Yu, Liping Tong, Di Chen
Summary: Temporomandibular joint (TMJ) osteoarthritis (OA) is a TMJ disorder characterized by pain, movement limitation, cartilage degeneration, and joint dysfunction. This review article summarizes recent findings on signaling pathways involved in TMJ OA development and progression, highlighting the importance of understanding these pathways for potential therapeutic strategies. Multiple signaling pathways, including Wnt/beta-catenin, TGF-beta and BMP, Indian Hedgehog, FGF, NF-kappa B, and Notch pathways, are implicated in the pathological process of TMJ OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dan Mao, Mingsong Wu, Jiying Wei, Xiangwen Zhou, Lan Yang, Fang Chen
Summary: This study found that miR-101a-3p levels were significantly lower in the rat inflammation model with TMJOA and inflamed chondrocytes than in the normal group. Additionally, miR-101a-3p substantially promoted apoptosis of chondrocytes, with its mechanism probably involving interaction with its target genes UBE2D1 and FZD4.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xinqi Huang, Xuefeng Pan, Xiner Xiong, Zhihe Zhao, Xiao Cen
Summary: The number of people suffering from temporomandibular joint osteoarthritis (TMJOA) is increasing. TMJOA causes joint noise, pain on TMJ and/or masticatory muscles, and restricted mandibular movement, which significantly impact daily activities. This review focuses on recently developed drug delivery systems for TMJOA treatment, discussing their effects, duration, safety, and limitations, and providing insights for the development of TMJOA therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Bingqiang Hua, Jin Qiu, Xiaoping Ye, Yiwen Kuang, Xianwen Liu
Summary: This study reveals the significant role of epigenetic PPAR gamma dysregulation in the pathogenesis of TMJOA. The suppression of PPAR gamma can be alleviated by DNA demethylation intervention, leading to cartilage restoration and stabilizing cartilage homeostasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Physiology
Chuan-Bin Wu, Tie Ma, Lin Ma, Qiang Wang, Qing Zhou
Summary: This study investigated the expression of Piezo1 in a rat temporomandibular joint osteoarthritis animal model and explored its mechanism for inducing inflammatory changes. The results showed that the degree of condylar destruction could be improved by influencing the expression of pSmad3.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Siobhan S. Rickert, Philip H. Kass, Frank J. M. Verstraete
Summary: The prevalence of temporomandibular joint osteoarthritis (TMJ-OA) varied across different species, with male individuals being more affected in walrus, North American brown bear, polar bear, American black bear, and California mountain lion. Adult specimens were more affected by TMJ-OA than young adults in harbor seal, fur seal, walrus, and kit fox. Only three species, the harbor seal, northern fur seal, and polar bear, showed a significant increase in TMJ-OA prevalence when their teeth had attrition and abrasion.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Won Jung, Kyung-Eun Lee, Bong-Jik Suh, Hyun Seok, Dae-Woo Lee
Summary: This study developed a diagnostic support tool using pretrained models to classify panoramic images of the temporomandibular joint (TMJ) into normal and osteoarthritis (OA) cases. The trained models exhibited high accuracy, with the highest accuracy in OA classification, and improved the diagnostic power of TMJ-OA. It can be effectively applied by dentists as a screening diagnostic tool for TMJ-OA.
Review
Thermodynamics
Zipei Su, Yanxin Hu, Shaobin Zheng, Tingting Wu, Kaizhao Liu, Minghan Zhu, Jin Huang
Summary: Due to its simple structure and excellent heat transfer performance, pulsating heat pipe (PHP) is widely used in different heat management fields. The complex heat transfer mechanism and various influencing factors make it difficult to predict the heat transfer performance of PHP. Therefore, a large number of visualization researches have been conducted to further improve the heat transfer mechanism and theory of PHP. This paper provides an overview of the latest progress in PHP visualization and summarizes and prospects the visualization studies of PHP with different visualization techniques, operating conditions, structural parameters, and working fluids, providing a reference for future visualization research.
APPLIED THERMAL ENGINEERING
(2023)
Article
Thermodynamics
Tingting Wu, Changhong Wang, Yanxin Hu, Zhixuan Liang, Changxiang Fan
Summary: In this study, a second-order equivalent circuit model considering the hysteresis effect of the battery was developed, and a combined EIS and HPPC characterization method was used for parameter identification. The results demonstrated that this method could accurately extract and analyze the battery parameters with different time scales. Additionally, it was found that the polarization internal resistance of the battery had a stronger temperature dependence, and the heat generation rate of the battery increased with decreasing temperature.
Article
Physics, Multidisciplinary
Tingting Wu, Chunhe Song, Peng Zeng, Changqing Xia
Summary: This paper proposes a clustering-based redundancy identification framework for model pruning, which considers the perspective of structural redundancy. The framework performs cluster analysis on filters in each layer to generate similar sets with different functions, identifies redundant filters within these sets, and automatically determines the pruning rate of each layer. Extensive experiments on various benchmark network architectures and datasets demonstrate the effectiveness of the proposed framework.
Article
Environmental Sciences
Feifei Liu, Feng Zhou, Ke Zhang, Tingting Wu, Mengnan Pan, Xiangxiang Wang, Jiahui Tong, Zhongyang Chen, Hao Xiang
Summary: This study investigated the relationship between sleep disorders and environmental factors such as air pollution and greenness in middle-aged and elderly individuals in China. The results showed that air pollution was positively associated with sleep disorders and reduced sleep duration, while higher levels of greenness could protect sleep health from the side effects of air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tingting Wu, Bingxin Zhao, Chengyu Cai, Yuyang Chen, Yujuan Miao, Jinmeng Chu, Yi Sui, Fuqiang Li, Wenqi Chen, Yong Cai, Fei Wang, Jingji Jin
Summary: Yin Yang 1 (YY1) is a transcription factor that controls gene expression and plays a crucial role in various cancers. The MOF-containing MSL HAT complex was found to regulate YY1 stability and transcriptional activity in an acetylation-dependent manner. Acetylation by MOF promoted the degradation of YY1 through the ubiquitin-proteasome pathway. The acetylation-ubiquitin mode of YY1 was found to be important for tumor cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Tingting Wu, Chunhe Song, Peng Zeng
Summary: This article introduces a novel and efficient pruning method based on filter similarity, which evaluates the similarity between filters instead of the importance of individual filters. The proposed method calculates pairwise filter similarity in a convolutional layer and obtains the similarity distribution. Filters with high similarity to others are then deleted or set to zero. The algorithm does not require a specified pruning rate for each layer and achieves satisfactory tradeoff between accuracy and memory in different scenarios through iterative pruning strategies.
FRONTIERS IN NEUROROBOTICS
(2023)
Article
Computer Science, Information Systems
Hao Zhang, Tingting Wu, Siyao Cheng, Jie Liu
Summary: Federated learning (FL) training on distributed edge devices has been an area of interest. The heterogeneity of client data affects the performance of FL. We propose FedCos, which reduces the directional inconsistency of local models with a cosine-similarity penalty. Experimental results show that FedCos outperforms baselines in various FL scenarios and improves communication efficiency by 2-5 times.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Bing Li, Yutao Li, Hong-Shen Zhang, Ting-Ting Wu, Sijie Guo, An-Min Cao
Summary: Li2ZrCl6 is a low-cost Li+-conducting chloride electrolyte with a trigonal structure that is stable at high voltages and compatible with high-voltage cathodes. However, its low room-temperature ionic conductivity, poor stability in different solvents and at high temperatures limit its application in next-generation all-solid-state batteries. In this study, new oxychloride electrolytes were prepared with different molar ratios of Li2O, ZrCl4, and LiCl, replacing Cl- with O2- anion to optimize the electrolyte performance. The introduction of Li2O greatly improved the conductivity and stability of the electrolyte, enabling the stable cycling of all-solid-state Li-In/LiCoO2 batteries.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Physical
Si-Dong Zhang, Mu-Yao Qi, Sijie Guo, Yong-Gang Sun, Ting-Ting Wu, Hong-Shen Zhang, Si-Qi Lu, Fanqi Meng, Qinghua Zhang, Lin Gu, Zhiwei Zhao, Zhangquan Peng, Hongchang Jin, Hengxing Ji, Ying-Rui Lu, Ting-Shan Chan, Ran Duan, An-Min Cao
Summary: A multifunctional shell of MgO/Li3PO4 was successfully fabricated on the surface of 4.6 V LiCoO2 cathode, which effectively stabilized the cathode by inhibiting interfacial side reactions and structure degradation. The shell not only prevented capacity decay but also improved Li+ transfer rate, leading to a high reversible capacity and outstanding rate capability.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Physical
Mu-Yao Qi, Si-Dong Zhang, Sijie Guo, Peng-Xiang Ji, Jian-Jun Mao, Ting-Ting Wu, Si-Qi Lu, Xing Zhang, Shu-Guang Chen, Dong Su, Guan-Hua Chen, An-Min Cao
Summary: In this study, surface modulation was used to stabilize the Ni-rich layered cathode and improve its cycle stability and rate capability. A wet-chemistry process was developed to deposit uniform ZrO(OH)(2) nanoshells and Li2ZrO3 nanoparticles on the surface of Ni0.905Co0.095(OH)(2)(NC0.9-OH) hydroxide precursors. This surface control technique achieved an optimized balance between surface stabilization and charge transfer, resulting in exceptional capacity retention and rate capability.
Article
Oncology
Qian Xiang, Zhe Wang, Guangyan Mu, Qiufen Xie, Zhiyan Liu, Shuang Zhou, Hanxu Zhang, Zining Wang, Jie Jiang, Kun Hu, Yatong Zhang, Zinan Zhao, Dongdong Yuan, Liping Guo, Tingting Wu, Jinhua Zhang, Na Wang, Jing Xiang, Zhichun Gu, Jianjun Sun, Yimin Cui
Summary: This study aimed to identify genetic variants associated with the variability of pharmacodynamics and bleeding risk of rivaroxbaban in patients with nonvalvular atrial fibrillation (NVAF). The peak anti-FXa level was significantly related to bleeding events within 12 months. SUSD3 rs76292544 was associated with 12-month bleeding events and five SNPs (NCMAP rs4553122, PRF1 rs885821, PRKAG2 rs12703159, rs13224758, and POU2F3 rs2298579) were associated with peak anti-FXa level.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Tingting Wu, Chunhe Song, Peng Zeng
Summary: This paper proposes an efficient federated training framework based on model pruning to address the problem of insufficient computing and communication resources in edge devices. The framework dynamically selects neurons or convolution kernels before global model release, prunes a current optimal subnet, and then issues the compressed model for training. The framework also introduces a new parameter aggregation update scheme to reduce the error caused by pruning.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Computer Science, Theory & Methods
Hao Zhang, Tingting Wu, Zhifeng Ma, Feng Li, Jie Liu
Summary: Distributed stochastic gradient descent (SGD) algorithms are commonly used to speed up deep learning model training by employing multiple computational devices in parallel. Top-k sparsification is an effective method to reduce communication overhead, but traditional implementations have limitations in training efficiency and model performance. This paper introduces a Dynamic Layer-wise Sparsification (DLS) mechanism and its extensions, DLS(s), which balances efficiency and performance by adjusting sparsity ratios of layers. Experimental results show that DLS(s) outperforms existing methods in terms of both performance and training time.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2023)
Article
Thermodynamics
Tingting Wu, Changhong Wang, Yanxin Hu, Xiaoxing Zeng, Mengjie Song
Summary: Phase change materials (PCM) are considered a promising technology for battery thermal management. However, the migration of microscopic components and brittle fracture hinder their application. This paper prepared a polyurethane (PU) PCM and identified PU400 as the best choice with a latent heat of 98.8 J/g and strain of 10% by weighing the relationship between thermal storage capacity and mechanical properties. The use of hydroxylated carbon nanotubes (CNT-OH) improved the heat transfer performance, with a thermal conductivity of 1.3 W/(m·K) at 5% CNT-OH content.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Environmental Sciences
Shi Chen, Yang Yang, Tingting Wu
Summary: This paper selects 248 resource-based cities in China from 2011 to 2019 as research objects to test the relationship between digital economy and regional green total factor productivity. The findings show that there is a nonlinear relationship between the two, with an inverted U-shape. The digital economy can influence regional green total factor productivity through the path transmission mechanism of regional technological innovation, industrial structure, and environmental regulation. The effect of the digital economy on regional green total factor productivity is heterogeneous, especially in the eastern region and cities with high human capital level.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
