Exploring mechanisms of FGF signalling through the lens of structural biology

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development

(2012) X. Qu et al.   DEVELOPMENT

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Dynamics and Distribution of Klothoβ (KLB) and Fibroblast Growth Factor Receptor-1 (FGFR1) in Living Cells Reveal the Fibroblast Growth Factor-21 (FGF21)-induced Receptor Complex

(2012) Aaron Y. K. Ming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor

(2012) Regina Goetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands

(2012) R. Goetz et al.   MOLECULAR AND CELLULAR BIOLOGY

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

(2012) Johan W. Jonker et al.   NATURE

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

(2012) L. Darryl Quarles   Nature Reviews Endocrinology

Hormone-like fibroblast growth factors and metabolic regulation

(2011) Yun Chau Long et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

(2011) N. Itoh et al.   JOURNAL OF BIOCHEMISTRY

A Systematic Study of Site-specific GalNAc-typeO-Glycosylation Modulating Proprotein Convertase Processing

(2011) Katrine Ter-Borch Gram Schjoldager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lacrimal Gland Development and Fgf10-Fgfr2b Signaling Are Controlled by 2-O- and 6-O-sulfated Heparan Sulfate

(2011) Xiuxia Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Function of Fibroblast Growth Factor 18 in the Ovarian Follicle in Cattle1

(2010) Valerio M. Portela et al.   BIOLOGY OF REPRODUCTION

FGF signalling: diverse roles during early vertebrate embryogenesis

(2010) K. Dorey et al.   DEVELOPMENT

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Distinct FGFs promote differentiation of excitatory and inhibitory synapses

(2010) Akiko Terauchi et al.   NATURE

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of calcineurin with substrates and targeting proteins

(2010) Huiming Li et al.   TRENDS IN CELL BIOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

(2009) Teruyo Nakatani et al.   FASEB JOURNAL

Regulation and action of fibroblast growth factor 17 in bovine follicles

(2009) M F Machado et al.   JOURNAL OF ENDOCRINOLOGY

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

(2009) J. Kalinina et al.   MOLECULAR AND CELLULAR BIOLOGY

FGF9 monomer–dimer equilibrium regulates extracellular matrix affinity and tissue diffusion

(2009) Masayo Harada et al.   NATURE GENETICS

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Graded Levels of FGF Protein Span the Midbrain and Can Instruct Graded Induction and Repression of Neural Mapping Labels

(2009) Yao Chen et al.   NEURON

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

(2009) H. P. Makarenkova et al.   Science Signaling

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Glycosaminoglycan affinity of the complete fibroblast growth factor family

(2008) Masahiro Asada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

(2008) Noriko Gotoh   CANCER SCIENCE

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice

(2008) John Falardeau et al.   JOURNAL OF CLINICAL INVESTIGATION

A crystallographic snapshot of tyrosine trans-phosphorylation in action

(2008) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY