Article
Multidisciplinary Sciences
Candice Sartre, Francois Peurois, Marie Ley, Marie-Helene Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Yann Ferrandez, Jacqueline Cherfils
Summary: EPAC1 is a cAMP-activated GEF for Rap GTPases and a major transducer of cAMP signaling. The authors demonstrate that anionic membranes can activate EPAC1 independently of cAMP, enhance its affinity for cAMP, and synergistically increase GEF activity with cAMP.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Yi Wang, Wanting Yu, Lingfang Ran, Zhong Chen, Chuannan Wang, Yang Dou, Yuanyuan Qin, Qingwei Suo, Yaohua Li, Jianyan Zeng, Aimin Liang, Yonglu Dai, Yiping Wu, Xufen Ouyang, Yuehua Xiao
Summary: The interactions between DELLA and NAC proteins in cotton stems mediate GA signaling to regulate the formation of secondary cell walls, as discovered through the use of a new system and gene silencing method.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yusuf Ilker Yaman, Sharad Ramanathan
Summary: The development of mammals involves various morphogenetic events, such as axial elongation, somitogenesis, and neural tube formation. In this study, axially elongating organoids were created from human pluripotent stem cells to understand the signals regulating human axial morphogenesis. The organoids consisted of a neural tube and segmented presomitic mesoderm, with the somite differentiation gene MESP2 being activated in sync with segmentation clock waves. Perturbations revealed the distinct roles of FGF and WNT signaling in axial elongation and somitogenesis, with FGF signaling gradients driving the segmentation clock waves. This work provides a valuable tool to study the mechanisms of human embryogenesis by generating and manipulating organoids that faithfully recapitulate multiple axial tissues.
Review
Biochemistry & Molecular Biology
Dongun Lee, Jeong-Hee Hong
Summary: This review summarizes the role of PyK2 in the cancer microenvironment, including its interaction with acidification and cancer-associated molecules, and highlights its relationship with cancer metastasis and potential as a therapeutic target for cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Josef J. J. Jareczek, Corrinne E. E. Grover, Jonathan F. F. Wendel
Summary: Cotton fiber, a predominant plant textile globally, serves as a model for plant cell wall biosynthesis. The developmental process of cotton fiber involves multiple stages, including fiber initiation, elongation, cell wall formation, thickening, maturation, and cell death. The complex restructuring of genome-wide gene expression and physiological/biosynthetic processes during each stage contribute to the production of elongated cellulose fibers that are crucial for the cotton industry. This article provides an overview of this developmental process, highlighting its temporal and evolutionary dimensions, and proposes potential avenues for improving cotton as a crop plant.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Qing Zhang, Jianglin Zheng, Wenjie Wu, Haiyan Lian, Natasha Iranzad, Endi Wang, Lianhe Yang, Xuan Wang, Xiaobing Jiang
Summary: Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. We found that TRIM56, a RING-finger domain containing E3 ubiquitin ligase, was highly expressed in glioma and correlated with malignant phenotypes and poor prognosis. TRIM56 promoted glioma cell migration and invasion by regulating IQGAP1 ubiquitination to activate CDC42. Targeting this mechanism could be a potential treatment strategy for glioma.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Cecilia Primo, Catherine Navarre, Francois Chaumont, Bruno Andre
Summary: This research discovered that TORC1 activity in tobacco cells is strongly influenced by the activity of plasma membrane H+-ATPases. When H+-ATPases are stimulated by fusicoccin, TORC1 activity can be activated. These results suggest that plant H+-ATPases play an important role in TOR signaling.
Article
Cell Biology
Liping Zhu, Huiqin Wang, Jiaojie Zhu, Xiaosi Wang, Bin Jiang, Liyong Hou, Guanghui Xiao
Summary: Continuous plant growth relies on cell division and elongation, which is regulated by brassinosteroids (BR). In this study, the researchers used cotton fiber to investigate cell-specific BR signaling and found that the transcriptional activator GhBES1 promotes fiber elongation by activating GhCERP, a protein related to cell elongation. GhCERP then transmits the BR signal to its target gene GhEXPA3-1, which ultimately promotes fiber cell elongation. Furthermore, the BR-mediated BES1-CERP-EXPA3 signaling cascade also promotes root and hypocotyl growth in Arabidopsis, indicating its broad significance in regulating BR-promoted cell elongation.
Article
Biochemistry & Molecular Biology
Annika Klimpel, Katharina Stillger, Janica L. Wiederstein, Marcus Krueger, Ines Neundorf
Summary: Cysteine prenylation is a post-translational modification that controls important biological functions of proteins. This modification mainly occurs at the C-terminal CaaX box of eukaryotic proteins. New tools, such as cell-permeable peptides with a CaaX motif, have been developed to study and regulate this modification.
Article
Cell Biology
Carlos Garcia-Padilla, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Angel Duenas, Maria del Mar Munoz-Gallardo, Isabel S. Garcia-Valencia, Lledo Palencia-Vincent, Amelia Aranega, Diego Franco
Summary: Bmp and Fgf signaling are involved in embryonic development, and their modulation of microRNAs plays a crucial role in regulating cell fate during cardiomyogenesis and PE/ST development. However, the role of Bmp and Fgf signaling in mouse PE/ST development is different from that in chicken, and their impact on cardiomyogenesis and fibrogenesis is limited. Species-specific differences in regulating PE/ST cardiomyogenic lineage commitment are supported by the data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agronomy
Fan Xu, Li Wang, Jun Xu, Qian Chen, Caixia Ma, Li Huang, Guiming Li, Ming Luo
Summary: In this study, it was found that GhIQD10 affects cotton fiber growth by interacting with GhCaM7 through calcium signaling.
Article
Cell Biology
Chan Wen, Chen Wang, Conghui Hu, Tiantian Qi, Ruihua Jing, Yunqing Wang, Ming Zhang, Yongping Shao, Cheng Pei
Summary: Posterior capsular opacification (PCO) can lead to visual loss after cataract surgery, and REPS2 plays a crucial role in regulating cell proliferation and migration in cataract patients.
CELLULAR SIGNALLING
(2022)
Article
Developmental Biology
Ayan T. Ray, Philippe Soriano
Summary: Loss of FGF signaling leads to defects in salivary gland branching. Disruption of Fgfr1 and Fgfr2 expression in salivary gland epithelial cells reveals their coordinated function in regulating branching. Non-canonical FGF signaling mechanisms involving cell-cell and cell-matrix adhesion play a role in salivary gland branching morphogenesis.
Article
Plant Sciences
Baojun Chen, Yaru Sun, Zailong Tian, Guoyong Fu, Xinxin Pei, Zhaoe Pan, Mian Faisal Nazir, Song Song, Hongge Li, Xiaoyang Wang, Ning Qin, Jiandong Shang, Yuchen Miao, Shoupu He, Xiongming Du
Summary: This study revealed the role of GhGASA10-1 in cotton fiber development, showing its involvement in promoting fiber elongation by regulating cell elongation. GhGASA10-1 may promote fiber elongation by regulating cellulose synthesis induced by IAA.
Review
Cell Biology
Aftab Taiyab, Judith West-Mays
Summary: Injury to the ocular lens disrupts cell-cell and cell-capsule/basement membrane interactions, leading to a series of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that play a crucial role in the induction and progression of epithelial-mesenchymal transition (EMT) and fibrosis of lens epithelial cells. The lens provides a simple and ideal system to study injury-induced signaling pathways associated with EMT and fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Renata E. Gordon, Li Zhang, Suraj Peri, Yin-Ming Kuo, Fang Du, Brian L. Egleston, Jessica M. Y. Ng, Andrew J. Andrews, Igor Astsaturov, Tom Curran, Zeng-Jie Yang
CLINICAL CANCER RESEARCH
(2018)
Article
Immunology
Tsukasa Nabekura, Zhiying Chen, Casey Schroeder, Taeju Park, Eric Vivier, Lewis L. Lanier, Dongfang Liu
JOURNAL OF IMMUNOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Tom Curran
Article
Oncology
Fang Du, Larra Yuelling, Eric H. Lee, Yuan Wang, Shengyou Liao, Yan Cheng, Li Zhang, Chaonan Zheng, Suraj Peri, Kathy Q. Cai, Jessica M. Y. Ng, Tom Curran, Peng Li, Zeng-Jie Yang
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Taeju Park, Tom Curran
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Qianhai Fan, Tingting Gong, Chaonan Zheng, Jessica M. Y. Ng, Jianquan Chen, Cynthia Myers, Harvey Hensley, Tom Curran, Zeng-jie Yang
Summary: Cholesterol plays a critical role in bone development, while statins, which inhibit the Hh pathway, can be used to treat medulloblastoma without affecting bone growth.
Article
Cell Biology
Mai T. Dang, Michael Gonzalez, Krutika S. Gaonkar, Komal S. Rathi, Patricia Young, Sherjeel Arif, Li Zhai, Zahidul Alam, Samir Devalaraja, Tsun Ki Jerrick To, Ian W. Folkert, Pichai Raman, Jo Lynne Rokita, Daniel Martinez, Jaclyn N. Taroni, Joshua A. Shapiro, Casey S. Greene, Candace Savonen, Fernanda Mafra, Hakon Hakonarson, Tom Curran, Malay Haldar
Summary: The study revealed significant changes in the composition of TAMs in medulloblastomas (MB) under different treatment modalities, with radiation inducing an immunosuppressive subset of TAMs. These findings highlight the important role of TAMs in tumor progression and response to therapy.
Review
Cell Biology
Taeju Park
Summary: Crk and CrkL, cellular counterparts of the viral oncoprotein v-Crk, are frequently overexpressed in human cancers and associated with poor prognosis. Gene knockdown or overexpression of Crk and CrkL can affect tumor cell functions, making them potential targets for cancer therapy. Studies suggest a comprehensive understanding of the distinct and overlapping roles of Crk and CrkL in tumor cell functions is crucial for developing effective therapeutic strategies.
Editorial Material
Medicine, Research & Experimental
Susan M. Abdel-Rahman, Michelle P. Wimes, Tom Curran
Summary: Individuals who identify as Black, indigenous, and people of color experience health disparities due to lack of empirical evidence for various treatments in their medical management. This paper proposes a new benchmarking strategy for evaluating racial and ethnic representation in clinical research, aiming to increase accountability for diversity and inclusion among organizations conducting clinical research.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Genetics & Heredity
Ana S. A. Cohen, Emily G. Farrow, Ahmed T. Abdelmoity, Joseph T. Alaimo, Shivarajan M. Amudhavalli, John T. Anderson, Lalit Bansal, Lauren Bartik, Primo Baybayan, Bradley Belden, Courtney D. Berrios, Rebecca L. Biswell, Pawel Buczkowicz, Orion Buske, Shreyasee Chakraborty, Warren A. Cheung, Keith A. Coffman, Ashley M. Cooper, Laura A. Cross, Tom Curran, Thuy Tien T. Dang, Mary M. Elfrink, Kendra L. Engleman, Erin D. Fecske, Cynthia Fieser, Keely Fitzgerald, Emily A. Fleming, Randi N. Gadea, Jennifer L. Gannon, Rose N. Gelineau-Morel, Margaret Gibson, Jeffrey Goldstein, Elin Grundberg, Kelsee Halpin, Brian S. Harvey, Bryce A. Heese, Wendy Hein, Suzanne M. Herd, Susan S. Hughes, Mohammed Ilyas, Jill Jacobson, Janda L. Jenkins, Shao Jiang, Jeffrey J. Johnston, Kathryn Keeler, Jonas Korlach, Jennifer Kussmann, Christine Lambert, Caitlin Lawson, Jean-Baptiste Le Pichon, James Steven Leeder, Vicki C. Little, Daniel A. Louiselle, Michael Lypka, Brittany D. McDonald, Neil Miller, Ann Modrcin, Annapoorna Nair, Shelby H. Neal, Christopher M. Oermann, Donna M. Pacicca, Kailash Pawar, Nyshele L. Posey, Nigel Price, Laura M. B. Puckett, Julio F. Quezada, Nikita Raje, William J. Rowell, Eric Rush, Venkatesh Sampath, Carol J. Saunders, Caitlin Schwager, Richard M. Schwend, Elizabeth Shaffer, Craig Smail, Sarah Soden, Meghan E. Strenk, Bonnie R. Sullivan, Brooke R. Sweeney, Jade B. Tam-Williams, Adam M. Walter, Holly Welsh, Aaron M. Wenger, Laurel K. Willig, Yun Yan, Scott T. Younger, Dihong Zhou, Tricia N. Zion, Isabelle Thiffault, Tomi Pastinen
Summary: This study provided comprehensive diagnostic and candidate analyses for a pediatric rare disease cohort, achieving diagnostic rates ranging from 11% to 34.5%. HiFi long-read genome sequencing yielded increased discovery rate with more rare coding SVs. Variants and genes of unknown significance remained common in nondiagnostic cases.
GENETICS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Taeju Park, Neka Large, Tom Curran
Summary: CrkL is more abundantly expressed than Crk in U-118MG cells, and both play essential overlapping roles in cell migration. Knockdown of CrkL leads to cell shrinkage and inhibits cell proliferation, adhesion, and invasion, while double knockdown of Crk and CrkL further enhances these effects.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
