- Home
- Publications
- Publication Search
- Publication Details
Title
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-04
DOI
10.3389/fphar.2020.00793
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- P2X7R as an independent prognostic indicator in gastric cancer
- (2020) Ilknur Calik et al. Bosnian Journal of Basic Medical Sciences
- Control of Metastases via Myeloid CD39 and NK Cell Effector Function
- (2020) Juming Yan et al. Cancer Immunology Research
- Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates
- (2020) Airi Rump et al. Frontiers in Immunology
- The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment
- (2019) Elena De Marchi et al. ONCOGENE
- ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
- (2019) Michele Proietti et al. Nature Communications
- Gut Microbiota and Cancer: From Pathogenesis to Therapy
- (2019) Silvia Vivarelli et al. Cancers
- Highly‐expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β‐catenin and mTOR/HIF1α/VEGF signaling
- (2019) Yingchi Zhang et al. INTERNATIONAL JOURNAL OF CANCER
- Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis
- (2019) Sara Zumerle et al. Cell Reports
- Ca2+ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus
- (2019) Xin Liang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of microglia and P2X7 receptors in gliomas
- (2019) Liyen Katrina Kan et al. JOURNAL OF NEUROIMMUNOLOGY
- Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket
- (2019) Anfal Bin Dayel et al. MOLECULAR PHARMACOLOGY
- Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
- (2019) Will Bailis et al. NATURE
- Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?
- (2019) Jonathan Benzaquen et al. Biomedical Journal
- The role of P2X7 receptor in prognosis and metastasis of colorectal cancer
- (2019) Ying Zhang et al. Advances in Medical Sciences
- Role of the P2X7 receptor in tumor-associated inflammation
- (2019) Elena Adinolfi et al. CURRENT OPINION IN PHARMACOLOGY
- P2X7 Interactions and Signaling – Making Head or Tail of It
- (2019) Robin Kopp et al. Frontiers in Molecular Neuroscience
- Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
- (2019) Alanna E. McCarthy et al. CELL
- High glucose inhibits osteogenic differentiation and proliferation of MC3T3‑E1 cells by regulating P2X7
- (2019) Jinsan Yang et al. Molecular Medicine Reports
- Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity
- (2019) Xian-Yang Li et al. Cancer Discovery
- Involvement of the P2X7 receptor in the migration and metastasis of tamoxifen-resistant breast cancer: effects on small extracellular vesicles production
- (2019) Miso Park et al. Scientific Reports
- Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
- (2019) Jean M. Mulcahy Levy et al. CELL DEATH AND DIFFERENTIATION
- The P2X7 receptor: A main player in inflammation
- (2018) Elena Adinolfi et al. BIOCHEMICAL PHARMACOLOGY
- The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
- (2018) Vancheswaran Gopalakrishnan et al. CANCER CELL
- Modulation of innate and adaptive immunity by P2X ion channels
- (2018) Francesco Di Virgilio et al. CURRENT OPINION IN IMMUNOLOGY
- The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
- (2018) Anke Di et al. IMMUNITY
- Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region
- (2018) Hong Huo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors
- (2018) Rebecca C. Allsopp et al. MOLECULAR PHARMACOLOGY
- Activating P2X7 Receptors Increases Proliferation of Human Pancreatic Cancer Cells via ERK1/2 and JNK
- (2018) Ji Hun Choi et al. PANCREAS
- The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies
- (2018) Laurence Zitvogel et al. SCIENCE
- The Elusive P2X7 Macropore
- (2018) Francesco Di Virgilio et al. TRENDS IN CELL BIOLOGY
- Involvement of P2X7 Receptor in Proliferation and Migration of Human Glioma Cells
- (2018) Zhenhua Ji et al. Biomed Research International
- Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis
- (2018) Henning Ulrich et al. Frontiers in Pharmacology
- P2X7 as a scavenger receptor for innate phagocytosis in the brain
- (2018) Ben J Gu et al. BRITISH JOURNAL OF PHARMACOLOGY
- The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
- (2018) Henrique Borges da Silva et al. NATURE
- ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival
- (2018) SM Gilbert et al. ONCOGENE
- A central role for P2X7 receptors in human microglia
- (2018) Laura Janks et al. Journal of Neuroinflammation
- High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer
- (2017) Fei Qian et al. HUMAN PATHOLOGY
- The P2X7 Receptor in Infection and Inflammation
- (2017) Francesco Di Virgilio et al. IMMUNITY
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury
- (2017) Luiz Eduardo Baggio Savio et al. JOURNAL OF HEPATOLOGY
- Use of luciferase probes to measure ATP in living cells and animals
- (2017) Giampaolo Morciano et al. Nature Protocols
- Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response
- (2017) Junbin Han et al. NUCLEAR MEDICINE COMMUNICATIONS
- On the permeation of large organic cations through the pore of ATP-gated P2X receptors
- (2017) Mahboubi Harkat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Localization of the gate and selectivity filter of the full-length P2X7 receptor
- (2017) Anja Pippel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
- (2017) Anna Wilkaniec et al. Purinergic Signalling
- Potential role of P2X7R in esophageal squamous cell carcinoma proliferation
- (2017) André A Santos et al. Purinergic Signalling
- P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
- (2017) Paola Fabbrizio et al. Frontiers in Cellular Neuroscience
- Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
- (2017) Go Kasuya et al. Nature Communications
- P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer
- (2017) Ju Young Bae et al. Oncotarget
- Structural insights into the nucleotide base specificity of P2X receptors
- (2017) Go Kasuya et al. Scientific Reports
- T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
- (2017) Lisa Perruzza et al. Cell Reports
- The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition
- (2017) Akira Karasawa et al. eLife
- Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives
- (2017) Paola de Andrade Mello et al. Frontiers in Immunology
- Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
- (2017) Rebecca C. Allsopp et al. Scientific Reports
- Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
- (2016) Federico Pietrocola et al. CANCER CELL
- P2 receptors in cancer progression and metastatic spreading
- (2016) Francesco Di Virgilio et al. CURRENT OPINION IN PHARMACOLOGY
- P2X7 receptor antagonists: a patent review (2010–2015)
- (2016) Jin-Hee Park et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Targeting of the P2X7 receptor in pancreatic cancer and stellate cells
- (2016) Andrea Giannuzzo et al. INTERNATIONAL JOURNAL OF CANCER
- ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity
- (2016) Julieta B. Pandolfi et al. JOURNAL OF IMMUNOLOGY
- Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
- (2016) Devin M. Swanson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion
- (2016) Jin-Hee Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- X-ray structures define human P2X3 receptor gating cycle and antagonist action
- (2016) Steven E. Mansoor et al. NATURE
- Medicinal chemistry of adenosine, P2Y and P2X receptors
- (2016) Kenneth A. Jacobson et al. NEUROPHARMACOLOGY
- Extracellular purines, purinergic receptors and tumor growth
- (2016) F Di Virgilio et al. ONCOGENE
- Comparative study of the P2X gene family in animals and plants
- (2016) Zhuoran Hou et al. Purinergic Signalling
- Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling?
- (2016) Carola Ledderose et al. Purinergic Signalling
- Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
- (2016) W. Danquah et al. Science Translational Medicine
- Next-Generation Connexin and Pannexin Cell Biology
- (2016) Jessica L. Esseltine et al. TRENDS IN CELL BIOLOGY
- Functional variant of the P2X7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma
- (2016) Yuh-Cheng Yang et al. Oncotarget
- Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells
- (2016) Valentina Salvestrini et al. Oncotarget
- P2X7 targeting inhibits growth of human mesothelioma
- (2016) Francesca Amoroso et al. Oncotarget
- Structural basis for subtype-specific inhibition of the P2X7 receptor
- (2016) Akira Karasawa et al. eLife
- Protein Profiling of Bladder Urothelial Cell Carcinoma
- (2016) Jinghai Hu et al. PLoS One
- Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process
- (2016) Carlos de Torre-Minguela et al. Scientific Reports
- Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death
- (2016) Erica Salaro et al. Scientific Reports
- A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90
- (2015) Christopher NJ Young et al. Autophagy
- A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats
- (2015) Liqian Sun et al. BEHAVIOURAL BRAIN RESEARCH
- Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives
- (2015) Sébastien Roger et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human
- (2015) Emily A. Caseley et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma
- (2015) Zheng Liu et al. CANCER SCIENCE
- Autophagy, Metabolism, and Cancer
- (2015) E. White et al. CLINICAL CANCER RESEARCH
- Emerging Roles of P2X Receptors in Cancer
- (2015) Elena Adinolfi et al. CURRENT MEDICINAL CHEMISTRY
- P2X Receptors and Inflammation
- (2015) Francesco Virgilio CURRENT MEDICINAL CHEMISTRY
- Involvement of the P2X7 Purinergic Receptor in Inflammation: An Update of Antagonists Series Since 2009 and their Promising Therapeutic Potential
- (2015) Davy Baudelet et al. CURRENT MEDICINAL CHEMISTRY
- ROS-dependent signal transduction
- (2015) Colleen R Reczek et al. CURRENT OPINION IN CELL BIOLOGY
- A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
- (2015) Brian Lord et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
- (2015) Alessia Franceschini et al. FASEB JOURNAL
- A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
- (2015) Ben J. Gu et al. HUMAN MOLECULAR GENETICS
- Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release
- (2015) Jargalsaikhan Dagvadorj et al. IMMUNITY
- Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease
- (2015) Alexander Eser et al. INFLAMMATORY BOWEL DISEASES
- P2X7 receptor as predictor gene for glioma radiosensitivity and median survival
- (2015) Marina P. Gehring et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Altered purinergic signaling in the tumor associated immunologic microenvironment in metastasized non-small-cell lung cancer
- (2015) Severin Schmid et al. LUNG CANCER
- The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells
- (2015) Andrea Giannuzzo et al. Molecular Cancer
- Physical basis of apparent pore dilation of ATP-activated P2X receptor channels
- (2015) Mufeng Li et al. NATURE NEUROSCIENCE
- The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma
- (2015) F Amoroso et al. ONCOGENE
- P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway
- (2015) JIYI XIA et al. ONCOLOGY REPORTS
- Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
- (2015) Francesca Graziano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of P2X7R in breast cancer tissue and the induction of apoptosis by the gene-specific shRNA in MCF-7 cells
- (2015) CHAO TAN et al. Experimental and Therapeutic Medicine
- Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients
- (2015) Anna Solini et al. Oncotarget
- PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions
- (2015) Rosa Gómez-Villafuertes et al. Scientific Reports
- Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death
- (2015) Dobrin Draganov et al. Scientific Reports
- P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy
- (2015) Anthony Sinadinos et al. PLOS MEDICINE
- Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia
- (2014) Shayan Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of the P2X7R by microRNA-216b in human breast cancer
- (2014) Luming Zheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
- (2014) E. Adinolfi et al. CANCER RESEARCH
- Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells
- (2014) Aram Ghalali et al. CARCINOGENESIS
- The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1/2 signalling pathway
- (2014) Stéphanie Chadet et al. CARCINOGENESIS
- P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia
- (2014) Chu-Hsin Shieh et al. GLIA
- Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization
- (2014) Lucy E. Robinson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PARACRINE STIMULATION OF P2X7 RECEPTOR BY ATP ACTIVATES A PROLIFERATIVE PATHWAY IN OVARIAN CARCINOMA CELLS
- (2014) Francisco G. Vázquez-Cuevas et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1 in Mouse Macrophage
- (2014) P. Pelegrin et al. JOURNAL OF IMMUNOLOGY
- P2X7Receptor Expression in Coexistence of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis
- (2014) Ji Hyun Kwon et al. Korean Journal of Pathology
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
- (2014) Anna Lisa Giuliani et al. PLoS One
- P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica
- (2014) Leonardo C. Monção-Ribeiro et al. PLoS One
- P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells
- (2014) Ying Qiu et al. PLoS One
- Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells
- (2014) Erina Takai et al. Purinergic Signalling
- ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
- (2014) G Bianchi et al. Cell Death & Disease
- Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2
- (2013) Guadalupe Martel-Gallegos et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Purinergic receptor P2X7: A novel target for anti-inflammatory therapy
- (2013) Nisha Mehta et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567
- (2013) Anindya Bhattacharya et al. BRITISH JOURNAL OF PHARMACOLOGY
- Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
- (2013) Bilel Jelassi et al. CARCINOGENESIS
- Purinergic signalling: from discovery to current developments
- (2013) Geoffrey Burnstock EXPERIMENTAL PHYSIOLOGY
- Human astrocytes express a novel NLRP2 inflammasome
- (2013) Julia Minkiewicz et al. GLIA
- Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection
- (2013) J. Scott Hale et al. IMMUNITY
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway
- (2013) Jingqin Fang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations
- (2013) M. W. Grol et al. JOURNAL OF CELL SCIENCE
- ROS production in phagocytes: why, when, and where?
- (2013) Sophie Dupré-Crochet et al. JOURNAL OF LEUKOCYTE BIOLOGY
- P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death
- (2013) Shu Bian et al. PLoS One
- The C-Terminus of Human Nucleotide Receptor P2X7 Is Critical for Receptor Oligomerization and N-Linked Glycosylation
- (2013) Lisa E. Wickert et al. PLoS One
- miR-150 Promotes Human Breast Cancer Growth and Malignant Behavior by Targeting the Pro-Apoptotic Purinergic P2X7 Receptor
- (2013) Songyin Huang et al. PLoS One
- The secretion of IL-1β and options for release
- (2013) Patrizia Piccioli et al. SEMINARS IN IMMUNOLOGY
- The trafficking and targeting of P2X receptors
- (2013) Lucy E. Robinson et al. Frontiers in Cellular Neuroscience
- Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms
- (2013) Lin-Hua Jiang et al. Frontiers in Pharmacology
- ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy
- (2013) Yuting Ma et al. OncoImmunology
- Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
- (2012) Edward C Keystone et al. ANNALS OF THE RHEUMATIC DISEASES
- The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels
- (2012) Anke Wesselius et al. BMC IMMUNOLOGY
- Expression of P2X7 Receptor Increases In Vivo Tumor Growth
- (2012) E. Adinolfi et al. CANCER RESEARCH
- CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
- (2012) W. C. Reinhold et al. CANCER RESEARCH
- Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures
- (2012) Niklas R Jørgensen et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women
- (2012) Alison Gartland et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7
- (2012) Fumie Hattori et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release
- (2012) Maria Barberà-Cremades et al. FASEB JOURNAL
- P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid
- (2012) Ben J. Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autocrine regulation of TGF- 1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells
- (2012) E. Takai et al. JOURNAL OF CELL SCIENCE
- Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate
- (2012) T. C. STOCK et al. JOURNAL OF RHEUMATOLOGY
- Molecular mechanism of ATP binding and ion channel activation in P2X receptors
- (2012) Motoyuki Hattori et al. NATURE
- Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
- (2012) Robert E Sorge et al. NATURE MEDICINE
- Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
- (2012) Brian D Gulbransen et al. NATURE MEDICINE
- Purinergic Signaling during Inflammation
- (2012) Holger K. Eltzschig et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Common Missense Variant in the ATP Receptor P2X7 Is Associated with Reduced Risk of Cardiovascular Events
- (2012) Olof Gidlöf et al. PLoS One
- Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation
- (2012) Nicole Schwarz et al. PLoS One
- P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line
- (2012) Marina Petersen Gehring et al. Purinergic Signalling
- Molecular and functional properties of P2X receptors—recent progress and persisting challenges
- (2012) Karina Kaczmarek-Hájek et al. Purinergic Signalling
- P2X7 receptor activation induces reactive oxygen species formation in erythroid cells
- (2012) Bin Wang et al. Purinergic Signalling
- The P2X7 receptor is a key modulator of aerobic glycolysis
- (2012) F Amoroso et al. Cell Death & Disease
- Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors
- (2012) Yosuke Kurashima et al. Nature Communications
- Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535
- (2011) Allen J. Duplantier et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Gain-of-function of P2X7 receptor gene variants in multiple sclerosis
- (2011) Olatz Oyanguren-Desez et al. CELL CALCIUM
- 4-aminopyridine Induces Apoptosis of Human Acute Myeloid Leukemia Cells via Increasing [Ca2+]i Through P2X7 Receptor Pathway
- (2011) Wei Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- P2X7 receptor positively regulates MyD88-dependent NF-κB activation
- (2011) Yanhui Liu et al. CYTOKINE
- Understanding the mechanism of IL-1β secretion
- (2011) Gloria Lopez-Castejon et al. CYTOKINE & GROWTH FACTOR REVIEWS
- A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases
- (2011) Nishkantha Arulkumaran et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Residues 155 and 348 Contribute to the Determination of P2X7Receptor Function via Distinct Mechanisms Revealed by Single-nucleotide Polymorphisms
- (2011) Helen J. Bradley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells
- (2011) Yolanda Gutiérrez-Martín et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P2X7 Is a Scavenger Receptor for Apoptotic Cells in the Absence of Its Ligand, Extracellular ATP
- (2011) B. J. Gu et al. JOURNAL OF IMMUNOLOGY
- Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
- (2011) Marco Tafani et al. Journal of Neuroinflammation
- P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness
- (2011) B Jelassi et al. ONCOGENE
- Activation and Regulation of Purinergic P2X Receptor Channels
- (2011) C. Coddou et al. PHARMACOLOGICAL REVIEWS
- Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer
- (2011) Beat M. Künzli et al. Purinergic Signalling
- C terminus of the P2X7 receptor: treasure hunting
- (2011) Helio Miranda Costa-Junior et al. Purinergic Signalling
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
- ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors
- (2011) U. Schenk et al. Science Signaling
- The human P2X7 receptor and its role in innate immunity
- (2011) J. S. Wiley et al. TISSUE ANTIGENS
- Mutation of Putative N-Linked Glycosylation Sites on the Human Nucleotide Receptor P2X7Reveals a Key Residue Important for Receptor Function
- (2010) Lisa Y. Lenertz et al. BIOCHEMISTRY
- P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells
- (2010) Patrick Constantinescu et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
- (2010) T. Woehrle et al. BLOOD
- Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment
- (2010) Marco Tafani et al. CANCER SCIENCE
- P2X purinergic receptor ligands: recently patented compounds
- (2010) Hendra Gunosewoyo et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
- (2010) Elena Adinolfi et al. FASEB JOURNAL
- Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion
- (2010) Leanne Stokes et al. FASEB JOURNAL
- The Hyposensitive N187D P2X7 Mutant Promotes Malignant Progression in Nude Mice
- (2010) Jing-Hui Chong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of ATP-induced cell death in the GL261 mouse glioma
- (2010) Alessandra S.K. Tamajusuku et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways
- (2010) Miho Shiratori et al. JOURNAL OF NEUROCHEMISTRY
- Block of Purinergic P2X7R Inhibits Tumor Growth in a C6 Glioma Brain Tumor Animal Model
- (2010) Jae K. Ryu et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating
- (2010) Z. Yan et al. JOURNAL OF NEUROSCIENCE
- Roles of P2X7 Receptor in Glial and Neuroblastoma Cells: The Therapeutic Potential of P2X7 Receptor Antagonists
- (2010) Synthia H. Sun MOLECULAR NEUROBIOLOGY
- Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells
- (2010) Pei-Shan Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: this dissociation regulates P2X7 pore formation
- (2009) Ben J. Gu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation
- (2009) Tiecheng Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice
- (2009) Prisca Honore et al. BEHAVIOURAL BRAIN RESEARCH
- Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors
- (2009) Mitsutoshi Tsukimoto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias
- (2009) Jing-Hui Chong et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells
- (2009) Oras Mistafa et al. BIOCHEMICAL PHARMACOLOGY
- The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP
- (2009) B. J. Gu et al. BLOOD
- CellMiner: a relational database and query tool for the NCI-60 cancer cell lines
- (2009) Uma T Shankavaram et al. BMC GENOMICS
- Atypical P2X7 receptor pharmacology in two human osteoblast-like cell lines
- (2009) SM Alqallaf et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
- (2009) Diana L Donnelly-Roberts et al. BRITISH JOURNAL OF PHARMACOLOGY
- Acid sphingomyelinase activity triggers microparticle release from glial cells
- (2009) Fabio Bianco et al. EMBO JOURNAL
- Autocrine regulation of T-cell activation by ATP release and P2X7 receptors
- (2009) Linda Yip et al. FASEB JOURNAL
- Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells
- (2009) Miyyada Boumechache et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of the P2X7Receptor Increases the Ca2+Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis
- (2009) Elena Adinolfi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes
- (2009) William R. Silverman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors
- (2009) Andrea Babelova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen
- (2009) Mark. P. Kuehnel et al. JOURNAL OF CELL SCIENCE
- Extracellular ATP Acting at the P2X7 Receptor Inhibits Secretion of Soluble HLA-G from Human Monocytes
- (2009) R. Rizzo et al. JOURNAL OF IMMUNOLOGY
- NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages
- (2009) S. F. Moore et al. JOURNAL OF IMMUNOLOGY
- The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore
- (2009) M. Monif et al. JOURNAL OF NEUROSCIENCE
- Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions
- (2009) Sébastien Roger et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Crystal structure of the ATP-gated P2X4 ion channel in the closed state
- (2009) Toshimitsu Kawate et al. NATURE
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
- (2009) François Ghiringhelli et al. NATURE MEDICINE
- Up-regulation of the inflammatory-reparative phenotype in human prostate carcinoma
- (2009) Linda Ravenna et al. PROSTATE
- Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function
- (2009) Chengqun Sun et al. Purinergic Signalling
- P2X7 receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin
- (2009) Xin Li et al. Purinergic Signalling
- Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking
- (2009) Lisa Y. Lenertz et al. Purinergic Signalling
- P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways
- (2009) Yan Qu et al. Purinergic Signalling
- P2X7: a growth-promoting receptor—implications for cancer
- (2009) Francesco Di Virgilio et al. Purinergic Signalling
- Expression of P2X5 in lymphoid malignancies results in LRH-1-specific cytotoxic T-cell-mediated lysis
- (2008) Ingrid M. Overes et al. BRITISH JOURNAL OF HAEMATOLOGY
- Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects
- (2008) A D Michel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts
- (2008) P. Gonnord et al. FASEB JOURNAL
- Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis
- (2008) Guido Beldi et al. HEPATOLOGY
- Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage
- (2008) Takuya Noguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
- (2008) Nattapon Panupinthu et al. JOURNAL OF CELL BIOLOGY
- 1513A>C Polymorphism in the P2X7Receptor Gene in Patients with Papillary Thyroid Cancer: Correlation with Histological Variants and Clinical Parameters
- (2008) Angela Dardano et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT
- (2008) Ayako Kataoka et al. JOURNAL OF NEUROCHEMISTRY
- ATP drives lamina propria TH17 cell differentiation
- (2008) Koji Atarashi et al. NATURE
- [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
- (2008) Diana L. Donnelly-Roberts et al. NEUROPHARMACOLOGY
- ATP-gated P2X cation-channels
- (2008) Michael F. Jarvis et al. NEUROPHARMACOLOGY
- Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
- (2008) Patrizia Pellegatti et al. PLoS One
- Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
- (2008) U. Schenk et al. Science Signaling
- Negative and positive allosteric modulators of the P2X7receptor
- (2007) A D Michel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Expression and function of the P2X7 receptor in rat C6 glioma cells
- (2007) Wei Wei et al. CANCER LETTERS
- Increased P2X7Receptor Expression and Function in Thyroid Papillary Cancer: A New Potential Marker of the Disease?
- (2007) Anna Solini et al. ENDOCRINOLOGY
- ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site
- (2007) Sahil Adriouch et al. FASEB JOURNAL
- Purinergic signalling
- (2006) Geoffrey Burnstock BRITISH JOURNAL OF PHARMACOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started