Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates

P2X7 Interactions and Signaling – Making Head or Tail of It

(2019) Robin Kopp et al.   Frontiers in Molecular Neuroscience

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

(2019) Alanna E. McCarthy et al.   CELL

The Elusive P2X7 Macropore

(2018) Francesco Di Virgilio et al.   TRENDS IN CELL BIOLOGY

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

(2018) Luiz E. B. Savio et al.   Frontiers in Pharmacology

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

(2017) Akira Karasawa et al.   eLife

P2X4: A fast and sensitive purinergic receptor

(2017) Jaanus Suurväli et al.   Biomedical Journal

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Comparative study of the P2X gene family in animals and plants

(2016) Zhuoran Hou et al.   Purinergic Signalling

Structural basis for subtype-specific inhibition of the P2X7 receptor

(2016) Akira Karasawa et al.   eLife

Cathelicidin modulates the function of monocytes/macrophages via the P2X7 receptor in a teleost, Plecoglossus altivelis

(2015) Chang-Hong Li et al.   FISH & SHELLFISH IMMUNOLOGY

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

(2015) Jiraporn Ousingsawat et al.   Nature Communications

The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity

(2013) Jana K. Eckert et al.   IMMUNITY

Is pannexin the pore associated with the P2X7 receptor?

(2013) A. V. P. Alberto et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Characterization of P2X7R and Its Function in the Macrophages of ayu, Plecoglossus altivelis

(2013) Yu-Qing He et al.   PLoS One

Primitive ATP-activated P2X receptors: discovery, function and pharmacology

(2013) Samuel J. Fountain   Frontiers in Cellular Neuroscience

Identification of 526 Conserved Metazoan Genetic Innovations Exposes a New Role for Cofactor E-like in Neuronal Microtubule Homeostasis

(2013) Melissa Y. Frédéric et al.   PLoS Genetics

P2X7 receptor regulation of non-classical secretion from immune effector cells

(2012) George R. Dubyak   CELLULAR MICROBIOLOGY

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

C terminus of the P2X7 receptor: treasure hunting

(2011) Helio Miranda Costa-Junior et al.   Purinergic Signalling

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

(2010) Cécile Delarasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Screen for Endocytic Motifs

(2010) Patrycja Kozik et al.   TRAFFIC

Expression of the P2X7Receptor Increases the Ca2+Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis

(2009) Elena Adinolfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor

(2009) Cécile Delarasse et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Genetics of the P2X7 receptor and human disease

(2009) Stephen J. Fuller et al.   Purinergic Signalling